WormBase Tree Display for Expr_pattern: Expr10608
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| Expr10608 | Expression_of | Gene | WBGene00006495 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00006495 | |||
| Expression_data | Anatomy_term | WBbt:0005813 | Certain | |
| GO_term | GO:0005886 | |||
| GO:0031430 | ||||
| GO:0009925 | ||||
| GO:0055120 | ||||
| Subcellular_localization | cpna-1 is significantly enriched or specific to body-wall muscle. CPNA-1 localizes to both M-lines and dense bodies, co-localizing with UNC-89 (M-lines), and with alpha-actinin (dense bodies). CPNA-1 co-localizes with the membrane proximal protein UNC-112, and therefore CPNA-1 is membrane-proximal in both dense bodies and M-lines. In addition, CPNA-1 and PAT-6 co-localize to both dense bodies and M-lines. This was shown with Anti-CPNA-1 antibodies and YFP tagged CPNA-1.CPNA-1 is close to the plasma membrane, at the same level as the ECM protein UNC-52 (perlecan), and the membrane proximal proteins UNC-112 and PAT-6, but also extending more deeply into the cell than these proteins. However, CPNA-1 does not extend as deeply into the cell as the M-line protein UNC- 89 (obscurin). CPNA-1 is observed in dense bodies both distal and proximal to the cell membrane, supporting the idea that some CPNA-1 molecules localize close to, or within the basal membrane of body wall muscle cells at integrin adhesion sites. | |||
| Type | Antibody | |||
| Reporter_gene | ||||
| Picture | WBPicture0000013028 | |||
| WBPicture0000013030 | ||||
| WBPicture0000013032 | ||||
| Reference | WBPaper00041875 | |||
| Transgene | WBTransgene00031379 |
