WormBase Tree Display for Expr_pattern: Expr16119
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| Expr16119 | Expression_of | Gene | WBGene00013082 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00013082 | |||
| Expression_data | Anatomy_term | WBbt:0003927 | Certain | |
| WBbt:0004096 | Certain | |||
| GO_term | GO:0036064 | |||
| Subcellular_localization | To investigate the expression and subcellular localization of GRDN-1 in A/PQR, we expressed the functional GFP-tagged full-length GRDN-1a isoform (henceforth referred to as GRDN-1::GFP) under its endogenous regulatory sequences (Nechipurenko et al., 2016). GRDN-1::GFP was expressed in A/PQR and localized to the cilia base in both neurons in adult hermaphrodites. The dynein light intermediate chain protein XBX-1 localizes to the basal body and undergoes bidirectional movement along the ciliary axoneme (Schafer et al., 2003). The GRDN-1::GFP signal overlapped with the proximal-most region of the XBX-1::tagRFP signal in PQR, suggesting that GRDN-1 localizes to the basal body in PQR. GRDN-1 also associates with the basal body in the distal segment of the outgrowing AQR dendrite. | |||
| Type | Reporter_gene | |||
| Reference | WBPaper00060888 | |||
| Transgene | WBTransgene00033466 |
