WormBase Tree Display for Expr_pattern: Expr1905
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| Expr1905 | Expression_of | Gene | WBGene00003222 | ||
|---|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00003222 | ||||
| Expression_data | Life_stage | WBls:0000024 | |||
| WBls:0000003 | |||||
| WBls:0000038 | |||||
| WBls:0000027 | |||||
| WBls:0000035 | |||||
| WBls:0000041 | |||||
| Anatomy_term | WBbt:0004575 | Certain | |||
| WBbt:0004576 | Certain | ||||
| WBbt:0005784 | Partial | ||||
| Remark | Expressed in distal, mitotic region of the germ line. | ||||
| GO_term | GO:0005694 | ||||
| Subcellular_localization | MES-4 is localized to nuclei and associated with chromosomes. Staining in one-cell embryos revealed that one chromosome of each parental set of six lacks MES-4. In four-cell embryos two chromosomes in each diploid nucleus lack MES-4. MES-4 is also restricted to the autosomes in the adult hermaphrodite germ line. After the near-disappearance and then reappearance of MES-4 during pachytene, it associates with five bivalents but is lacking from one, presumably the X. Thus, MES-4 is off the Xs when X-linked oocyte genes become detectably expressed in late pachytene. MES-4 staining in male germ lines resembles that in hermaphrodites. | ||||
| Type | Antibody | Rat polyclonal peptide antibody against the last 19 amino acids of MES-4. | |||
| Pattern | MES-4 is present in the distal, mitotic region of the germ line, barely detectable in the early- to mid-pachytene region, and up-regulated in later pachytene and in oocytes. In embryos, MES-4 is present in both somatic and germline nuclei until the 80- to 100-cell stage. Subsequently, MES-4 staining diminishes in somatic cells but persists in the primordial germ cells Z2 and Z3. | ||||
| Picture | WBPicture0000010692 | ||||
| Reference | WBPaper00005301 | ||||
| Antibody_info | WBAntibody00000524 |
