WormBase Tree Display for GO_term: GO:0043224

GO:0043224 Name: nuclear SCF ubiquitin ligase complex
  Definition: A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
  Synonym: Exact: nuclear cullin complex
      nuclear SCF complex
      nuclear Skp1/Cul1/F-box protein complex
  Status: Valid
  Type: Cellular_component
  Parent: Instance_of: GO:0000152
      GO:0019005
  Attributes_of: Index: Ancestor: GO:0000151
        GO:0000152
        GO:0005575
        GO:0005622
        GO:0005634
        GO:0019005
        GO:0031461
        GO:0032991
        GO:0043231
        GO:0043229
        GO:0043226
        GO:0043227
        GO:0110165
        GO:1902494
        GO:0140513
        GO:0140535
        GO:1990234
  Version: Gene Ontology releases/2023-11-15