WormBase Tree Display for GO_term: GO:0070877
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| GO:0070877 | Name | microprocessor complex | |
|---|---|---|---|
| Definition | A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs. | ||
| Status | Valid | ||
| Type | Cellular_component | ||
| Parent | Instance_of | GO:0140513 | |
| GO:1903095 | |||
| Attributes_of | Motif | INTERPRO:IPR040375 | |
| Index | Ancestor (15) | ||
| GO_annotation (17) | |||
| Version | Gene Ontology releases/2023-11-15 |
