WormBase Tree Display for GO_term: GO:1990620
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| GO:1990620 | Name | ANPR-A receptor complex | ||
|---|---|---|---|---|
| Definition | A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. | |||
| Synonym | Related | NPR1 receptor complex | ||
| Status | Valid | |||
| Type | Cellular_component | |||
| Parent | Instance_of | GO:0043235 | ||
| Attributes_of | Index | Ancestor | GO:0005575 | |
| GO:0032991 | ||||
| GO:0043235 | ||||
| Version | Gene Ontology releases/2023-11-15 |
