WormBase Tree Display for Gene: WBGene00001827

WBGene00001827 SMap: S_parent: Sequence: C46A5
  Identity: Version: 1
    Name: CGC_name: hcf-1
      Sequence_name: C46A5.9
      Molecular_name: C46A5.9
        C46A5.9.1
        CE26914
      Other_name: CELE_C46A5.9 Accession_evidence: NDB BX284604
      Public_name: hcf-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hcf
    Allele: WBVar00239352 Inferred_automatically: From strain object: XA8106
      WBVar02149359
      WBVar01500079
      WBVar00258926
      WBVar00091845
      WBVar01499395
      WBVar01499396
      WBVar00573529
      WBVar00429326
      WBVar00429327
      WBVar00429328
      WBVar01499633
      WBVar00429329
      WBVar02134196
      WBVar01908572
      WBVar00276070
      WBVar02152125
      WBVar01453171
      WBVar01729947
      WBVar01453172
      WBVar01453173
      WBVar00923199
      WBVar00923200
      WBVar00923201
      WBVar00923202
      WBVar00923203
      WBVar00923204
      WBVar00923205
      WBVar00923206
      WBVar00923207
      WBVar00923208
      WBVar00923209
      WBVar00923210
      WBVar00923211
      WBVar00923212
      WBVar00923213
      WBVar00923214
      WBVar01500245
      WBVar00923215
      WBVar00923216
      WBVar00923217
    Strain: WBStrain00031490
      WBStrain00040638
    RNASeq_FPKM (74)
    GO_annotation (33)
    Contained_in_operon: CEOP4614
    Ortholog (44)
    Paralog: WBGene00009978 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013461 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021751 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: hcf-1 encodes the C. elegans ortholog of human host cell factor (HCF-1), a transcriptional regulator that associates with histone modification enzymes and plays a role in cell cycle progression; in C. elegans, hcf-1 plays a role in regulation of cell division and mitotic histone modification; in addition, HCF-1 functions in determination of adult lifespan as a negative regulator of DAF-16, with which it physically interacts; HCF-1 is a ubiquitously expressed protein that localizes to the nucleus. Paper_evidence: WBPaper00031249
            WBPaper00032232
          Curator_confirmed: WBPerson1843
          Date_last_updated: 22 Dec 2009 00:00:00
      Automated_description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and regulation of DNA-templated transcription. Acts upstream of or within defense response to other organism and response to endoplasmic reticulum stress. Located in nucleus. Part of transcription regulator complex. Expressed widely. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Is an ortholog of human HCFC1 (host cell factor C1) and HCFC2 (host cell factor C2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111814 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4839)
  Molecular_info: Corresponding_CDS: C46A5.9
    Corresponding_transcript: C46A5.9.1
    Other_sequence (31)
    Associated_feature: WBsf651947
      WBsf651948
      WBsf230320
  Experimental_info: RNAi_result: WBRNAi00088935 Inferred_automatically: RNAi_primary
      WBRNAi00042584 Inferred_automatically: RNAi_primary
      WBRNAi00081844 Inferred_automatically: RNAi_primary
      WBRNAi00108478 Inferred_automatically: RNAi_primary
      WBRNAi00081815 Inferred_automatically: RNAi_primary
      WBRNAi00062165 Inferred_automatically: RNAi_primary
      WBRNAi00081891 Inferred_automatically: RNAi_primary
      WBRNAi00012019 Inferred_automatically: RNAi_primary
      WBRNAi00081780 Inferred_automatically: RNAi_primary
      WBRNAi00108483 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00005314
      WBCnstr00009024
      WBCnstr00009025
      WBCnstr00036664
    Construct_product: WBCnstr00005314
      WBCnstr00009025
      WBCnstr00010947
      WBCnstr00036664
    Regulate_expr_cluster (17)
    Antibody: WBAntibody00000977
      WBAntibody00001472
    Microarray_results (22)
    Expression_cluster: WBPaper00028451:Oogenic_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032425:up_in_rde-4
      WBPaper00035269:cde-1_regulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_downregulated
      WBPaper00046421:cdc-48.2(tm659)_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00052987:UV_upregulated_xpc-1;csb-1
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:AVH_parent
      WBPaper00061340:Parents_of_Y_DA6_DA7_DA9
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:C48B6.3_8645-hcf-1_11080
      WBPaper00061527:cyy-1_3136-hcf-1_2478
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025032:cluster_32
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032948:FedUp
      WBPaper00034739:N2lessDR1350
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00040963:TA200_down
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_45
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(83_min)
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_E
      [cgc6390]:intrinsic
    Interaction (118)
    WBProcess: WBbiopr:00000001
  Map_info: Map: IV Position: 3.47224 Error: 0.000901
    Positive: Positive_clone: C46A5 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4397
        4935
    Pseudo_map_position
  Reference (32)
  Remark: Sequence connection from [Liu Y, Hengartner MO, Herr W]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene