WormBase Tree Display for Gene: WBGene00006839

WBGene00006839 SMap: S_parent: Sequence: F09B9
  Identity: Version: 1
    Name: CGC_name: unc-115 Person_evidence: WBPerson261
      Sequence_name: F09B9.2
      Molecular_name: F09B9.2a
        F09B9.2a.1
        CE15759
        F09B9.2b
        CE02176
        F09B9.2b.1
      Other_name: CELE_F09B9.2 Accession_evidence: NDB BX284606
      Public_name: unc-115
    DB_info: Database: AceView gene XK771
        WormQTL gene WBGene00006839
        WormFlux gene WBGene00006839
        NDB locus_tag CELE_F09B9.2
        Panther gene CAEEL|WormBase=WBGene00006839|UniProtKB=Q95QM5
          family PTHR24213
        NCBI gene 181227
        RefSeq protein NM_077301.9
            NM_001029371.8
        TREEFAM TREEFAM_ID TF318042
        TrEMBL UniProtAcc Q95QM5
            Q19240
        UniProt_GCRP UniProtAcc Q95QM5
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele: WBVar00089174 Inferred_automatically: From strain object: CH121
          From strain object: SP1789
          From strain object: SP1981
      WBVar00088430 Inferred_automatically: From strain object: CX3709
      WBVar00144649 Inferred_automatically: From strain object: MT3790
          From strain object: PB1
      WBVar00089175
      WBVar01473682
      WBVar01551661
      WBVar01551662
      WBVar01551663
      WBVar01551664
      WBVar01551665
      WBVar01551666
      WBVar01551667
      WBVar00082195
      WBVar00082196
      WBVar01981208
      WBVar01179058
      WBVar01179059
      WBVar01179060
      WBVar01179061
      WBVar01179062
      WBVar01179063
      WBVar01179064
      WBVar01179065
      WBVar01179066
      WBVar01179067
      WBVar01179068
      WBVar01179069
      WBVar02083458
      WBVar01179070
      WBVar00062234
      WBVar01179071
      WBVar01179072
      WBVar01786914
      WBVar00062239
      WBVar01179073
      WBVar01179074
      WBVar01179075
      WBVar01179076
      WBVar01179077
      WBVar01179078
      WBVar01179079
      WBVar01179080
      WBVar01179081
      WBVar01179082
      WBVar01179083
      WBVar01179084
      WBVar01759025
      WBVar01179085
      WBVar01759026
      WBVar01179086
      WBVar01759027
      WBVar01179087
      WBVar01179088
      WBVar01759028
      WBVar01179089
      WBVar01179090
      WBVar01179091
      WBVar01179092
      WBVar01179093
      WBVar01179094
      WBVar01179095
      WBVar01179096
      WBVar01179097
      WBVar01179098
      WBVar01179099
      WBVar01179100
      WBVar01179101
      WBVar01179102
      WBVar01179103
      WBVar02116623
      WBVar00514484
      WBVar00514485
      WBVar00514486
      WBVar00514487
      WBVar00514488
      WBVar00514489
      WBVar00514490
      WBVar00514491
      WBVar00514492
      WBVar00514493
      WBVar00514494
      WBVar00514495
      WBVar00514496
      WBVar00514497
      WBVar00514498
      WBVar00099779
      WBVar02086835
      WBVar01620203
      WBVar01620204
      WBVar01620205
      WBVar01620206
      WBVar01620207
      WBVar01620208
      WBVar01620209
      WBVar00093751
      WBVar01845971
      WBVar02065873
      WBVar02065874
      WBVar01945961
      WBVar02001165
      WBVar01888410
      WBVar02139946
      WBVar01888411
      WBVar01888412
      WBVar01888413
      WBVar01888414
      WBVar01888415
      WBVar01888416
      WBVar01928050
      WBVar01498960
      WBVar01500067
    Legacy_information: See also e2225
      [C.elegansII] e2225mut : uncoordinated movement, severe kinker. Muscle structure appears normal. OA1: mn481. Cloned: predicted protein has N-term LIMb domain, C-term villin headpiece similarity. [FF; SP]
    Strain: WBStrain00003646
      WBStrain00027092
      WBStrain00030542
      WBStrain00034392
      WBStrain00034399
      WBStrain00037520
      WBStrain00005032
      WBStrain00005254
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (39)
    Structured_description: Concise_description: unc-115 encodes a protein that binds actin filaments and that is required for RAS signalling and UNC-40/netrin activity during axon pathfinding. Paper_evidence: WBPaper00005607
            WBPaper00005719
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables actin filament binding activity. Involved in neuron projection morphogenesis; regulation of filopodium assembly; and regulation of lamellipodium assembly. Located in basal plasma membrane and cytoplasm. Expressed in several structures, including PDE; excretory cell; pharynx; somatic nervous system; and vulva. Is an ortholog of human ABLIM2 (actin binding LIM protein family member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F09B9.2a
      F09B9.2b
    Corresponding_transcript: F09B9.2a.1
      F09B9.2b.1
    Other_sequence (45)
    Associated_feature (16)
    Transcription_factor: WBTranscriptionFactor000712
  Experimental_info: RNAi_result (17)
    Expr_pattern (11)
    Drives_construct (12)
    Construct_product: WBCnstr00007698
      WBCnstr00018995
      WBCnstr00020818
      WBCnstr00034126
    Antibody: WBAntibody00001164
    Microarray_results (29)
    Expression_cluster: WBPaper00029359_1142
      WBPaper00029359_1217
      WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1604
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00032976:dosage_compensated_genes
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041222:hlh-1(cc561)_upregulated
      WBPaper00041222:unc-120(st364)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ALN
      WBPaper00061340:AVB
      WBPaper00061340:AVK
      WBPaper00061340:AVL
      WBPaper00061340:DA
      WBPaper00061340:DB
      WBPaper00061340:DD
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:RIV
      WBPaper00061340:SIA
      WBPaper00061340:SIB
      WBPaper00061340:SMB
      WBPaper00061340:SMD
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:hlh-30_18579-unc-43_21739
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061651:AVA_enriched
      WBPaper00061651:AVF_enriched
      WBPaper00061651:AVG_enriched
      WBPaper00061651:AVJ_enriched
      WBPaper00061651:AVK_enriched
      WBPaper00061651:DA_enriched
      WBPaper00061651:DB01_enriched
      WBPaper00061651:DB_enriched
      WBPaper00061651:DVA_enriched
      WBPaper00061651:DVC_enriched
      WBPaper00061651:FLP_enriched
      WBPaper00061651:HSN_enriched
      WBPaper00061651:I4_enriched
      WBPaper00061651:NSM_enriched
      WBPaper00061651:PDB_enriched
      WBPaper00061651:PLN_enriched
      WBPaper00061651:PVR_enriched
      WBPaper00061651:SAB_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SIB_enriched
      WBPaper00061651:SMB_enriched
      WBPaper00061651:VA_enriched
      WBPaper00061651:VC_4_5_enriched
      WBPaper00061651:VC_enriched
      WBPaper00061651:VD_DD_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_5_5
      cgc4489_group_8
      WBPaper00025032:cluster_18
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037695:WC_5-day
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00053236:Starvation_regulated_GR1307
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_C
    Interaction (85)
    Anatomy_function: WBbtf0223
  Map_info: Map: X Position: 1.86244 Error: 0.006291
    Well_ordered
    Positive: Positive_clone: F09B9 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 3647
        3648
        3654
        3657
        3660
        3662
        3666
        6011
        7020
        7022
      Multi_point (31)
      Pos_neg_data (3)
  Reference (76)
  Method: Gene