sqv-2 encodes a glycosaminoglycan galactosyltransferase II, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; the common requirement for SQV-2 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.
Enables galactosylxylosylprotein 3-beta-galactosyltransferase activity. Involved in several processes, including egg-laying behavior; glycosaminoglycan biosynthetic process; and vulval development. Located in Golgi apparatus. Expressed in intestine. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome spondylodysplastic type 2 and spondyloepimetaphyseal dysplasia with joint laxity type 1. Is an ortholog of human B3GALT6 (beta-1,3-galactosyltransferase 6).