WormBase Tree Display for Gene: WBGene00006843
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| WBGene00006843 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-119 | Person_evidence | WBPerson261 | |||||
| Sequence_name | M142.1 | ||||||||
| Molecular_name | M142.1a | ||||||||
| M142.1a.1 | |||||||||
| CE06203 | |||||||||
| M142.1b | |||||||||
| CE43523 | |||||||||
| M142.1c | |||||||||
| CE44343 | |||||||||
| M142.1b.1 | |||||||||
| M142.1c.1 | |||||||||
| Other_name | 3L997 | Inferred_automatically | |||||||
| CELE_M142.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | unc-119 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Allele | WBVar02148854 | Inferred_automatically | From strain object: DE130 | ||||||
| WBVar02157633 | Inferred_automatically | From strain object: EG9814 | |||||||
| From strain object: EG9881 | |||||||||
| From strain object: EG9885 | |||||||||
| From strain object: EG9887 | |||||||||
| From strain object: EG9891 | |||||||||
| WBVar00145092 | Inferred_automatically | From strain object: NC694 | |||||||
| WBVar00859318 | |||||||||
| WBVar00859319 | |||||||||
| WBVar00859320 | |||||||||
| WBVar00859321 | |||||||||
| WBVar00859322 | |||||||||
| WBVar00859323 | |||||||||
| WBVar00859324 | |||||||||
| WBVar00859325 | |||||||||
| WBVar01500260 | |||||||||
| WBVar00859326 | |||||||||
| WBVar00859327 | |||||||||
| WBVar00859328 | |||||||||
| WBVar00859329 | |||||||||
| WBVar00859330 | |||||||||
| WBVar00859331 | |||||||||
| WBVar00859332 | |||||||||
| WBVar00859333 | |||||||||
| WBVar00859334 | |||||||||
| WBVar00859335 | |||||||||
| WBVar00859336 | |||||||||
| WBVar00859337 | |||||||||
| WBVar00859338 | |||||||||
| WBVar00859339 | |||||||||
| WBVar00322203 | |||||||||
| WBVar00145093 | |||||||||
| WBVar00322204 | |||||||||
| WBVar00145094 | |||||||||
| WBVar00145096 | |||||||||
| WBVar01701873 | |||||||||
| WBVar01578999 | |||||||||
| WBVar01701874 | |||||||||
| WBVar01701875 | |||||||||
| WBVar01701876 | |||||||||
| WBVar01499194 | |||||||||
| WBVar00565560 | |||||||||
| WBVar02013002 | |||||||||
| WBVar02013003 | |||||||||
| WBVar01567581 | |||||||||
| WBVar01567582 | |||||||||
| WBVar01567583 | |||||||||
| WBVar01567584 | |||||||||
| WBVar01567585 | |||||||||
| WBVar01499774 | |||||||||
| WBVar00179351 | |||||||||
| WBVar00179352 | |||||||||
| WBVar00179353 | |||||||||
| WBVar00179354 | |||||||||
| WBVar00179355 | |||||||||
| WBVar00179356 | |||||||||
| WBVar00179357 | |||||||||
| WBVar00179358 | |||||||||
| WBVar00179359 | |||||||||
| WBVar00179360 | |||||||||
| WBVar00144850 | |||||||||
| WBVar01952761 | |||||||||
| WBVar01952762 | |||||||||
| WBVar01952763 | |||||||||
| WBVar01952764 | |||||||||
| WBVar00261771 | |||||||||
| WBVar00261772 | |||||||||
| WBVar01952765 | |||||||||
| WBVar01409430 | |||||||||
| WBVar01268672 | |||||||||
| WBVar01952766 | |||||||||
| WBVar00408336 | |||||||||
| WBVar01409431 | |||||||||
| WBVar00408337 | |||||||||
| WBVar02046783 | |||||||||
| WBVar00408338 | |||||||||
| WBVar01268675 | |||||||||
| WBVar00408339 | |||||||||
| WBVar01268676 | |||||||||
| WBVar00408340 | |||||||||
| WBVar00320358 | |||||||||
| WBVar01268677 | |||||||||
| WBVar01268678 | |||||||||
| WBVar00320359 | |||||||||
| WBVar00408341 | |||||||||
| WBVar00408342 | |||||||||
| WBVar00408343 | |||||||||
| WBVar00408344 | |||||||||
| WBVar00408345 | |||||||||
| WBVar00408346 | |||||||||
| WBVar00408347 | |||||||||
| WBVar02132705 | |||||||||
| WBVar02132706 | |||||||||
| WBVar02132707 | |||||||||
| WBVar02132708 | |||||||||
| WBVar01448425 | |||||||||
| WBVar01507582 | |||||||||
| WBVar01507583 | |||||||||
| WBVar01507584 | |||||||||
| WBVar01507585 | |||||||||
| WBVar01507586 | |||||||||
| WBVar01507587 | |||||||||
| WBVar01507588 | |||||||||
| WBVar01723635 | |||||||||
| WBVar01542331 | |||||||||
| WBVar01918983 | |||||||||
| WBVar01918984 | |||||||||
| WBVar00252617 | |||||||||
| WBVar01963135 | |||||||||
| WBVar00859297 | |||||||||
| WBVar00859298 | |||||||||
| WBVar00859299 | |||||||||
| WBVar00859300 | |||||||||
| WBVar00859301 | |||||||||
| WBVar00859302 | |||||||||
| WBVar00859303 | |||||||||
| WBVar00859304 | |||||||||
| WBVar01499870 | |||||||||
| WBVar01499871 | |||||||||
| WBVar00859305 | |||||||||
| WBVar00318504 | |||||||||
| WBVar00318505 | |||||||||
| WBVar00859306 | |||||||||
| WBVar00859307 | |||||||||
| WBVar00859308 | |||||||||
| WBVar00859309 | |||||||||
| WBVar00859310 | |||||||||
| WBVar00859311 | |||||||||
| WBVar00859312 | |||||||||
| WBVar00859313 | |||||||||
| WBVar00859314 | |||||||||
| WBVar02036301 | |||||||||
| WBVar00859315 | |||||||||
| WBVar02118939 | |||||||||
| WBVar00859316 | |||||||||
| WBVar00859317 | |||||||||
| Possibly_affected_by | WBVar02152819 | ||||||||
| WBVar02153069 | |||||||||
| WBVar02153167 | |||||||||
| WBVar02153169 | |||||||||
| WBVar02153170 | |||||||||
| WBVar02153171 | |||||||||
| WBVar02153173 | |||||||||
| WBVar02154063 | |||||||||
| WBVar02158600 | |||||||||
| WBVar02158612 | |||||||||
| Legacy_information | See also e2498 | ||||||||
| [Maduro & Pilgrim] e2498::Tc1: strong unc, almost paralyzed adults, dumpyish, tends to curl; daf-d (daf-7 suppressible), weak FITC uptake; partially Egl; similar phenotype to eDf2; eDp6. ES3 (all stages), ME0. NA4 (ed3op, ed4oc, ed9: all similar to e2498, all putative nulls). Ref. DP. | |||||||||
| [C.elegansII] e2498::Tc1 : severe Unc, almost paralysed adults,dumpyish, tends to curl; Daf-d, partial Egl, partial Dyf. Normal muscle ultrastructure.ES3. ME0. OA3: ed3op, ed4oc, ed9 (all similar). Cloned: encodes predicted 219 aa novel protein. unc-119:GFP expressed extensively in axons. [Maduro & Pilgrim 1995] | |||||||||
| Strain (2313) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00003966 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Structured_description | Concise_description | unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues. | Paper_evidence | WBPaper00002306 | |||||
| WBPaper00003926 | |||||||||
| WBPaper00024591 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Dec 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable lipid binding activity. Involved in several processes, including body morphogenesis; dauer larval development; and regulation of multicellular organismal process. Located in axon. Expressed in several structures, including body wall musculature; ganglia; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in cone-rod dystrophy and immunodeficiency 13. Is an ortholog of human UNC119 (unc-119 lipid binding chaperone) and UNC119B (unc-119 lipid binding chaperone B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111987 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12565) | ||||
| DOID:0050572 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12565) | ||||||
| Molecular_info | Corresponding_CDS | M142.1a | |||||||
| M142.1b | |||||||||
| M142.1c | |||||||||
| Corresponding_transcript (3) | |||||||||
| Other_sequence (63) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern (18) | |||||||||
| Drives_construct (109) | |||||||||
| Construct_product (41) | |||||||||
| Antibody (3) | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (303) | |||||||||
| Map_info | Map | III | Position | 5.58925 | Error | 0.00446 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C27F7 | |||||||
| C44B9 | |||||||||
| M142 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Y39A1 | |||||||||
| Y60D9 | |||||||||
| Negative | Negative_clone | K02B6 | |||||||
| K11D9 | |||||||||
| T27G1 | |||||||||
| Mapping_data | 2_point | 4972 | |||||||
| 4973 | |||||||||
| 4974 | |||||||||
| Multi_point | 1715 | ||||||||
| 1716 | |||||||||
| 1717 | |||||||||
| Pos_neg_data | 4970 | ||||||||
| 4971 | |||||||||
| Reference (258) | |||||||||
| Remark | a sequence search shows strong similarity to C27H5.1 (II): a 92 a.a. region shows 26% identity, 51% similarity to UNC-119. | ||||||||
| Method | Gene |
