fre-1 encodes an NADPH-dependent flavin reductase; fre-1 is the downstream gene in an operon with dcs-1, which encodes a scavenger mRNA decapping enzyme; reporter fusions using dcs-1 upstream sequence direct expression throughout the life cycle in neurons and pharyngeal muscle; expression is present in dauer larvae and enhanced by heat shock.
Predicted to enable FMN binding activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity. Predicted to be involved in iron-sulfur cluster assembly. Located in nucleus. Expressed in neurons and pharyngeal muscle cell. Is an ortholog of human NDOR1 (NADPH dependent diflavin oxidoreductase 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.