WormBase Tree Display for Gene: WBGene00004264
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| WBGene00004264 | Evidence | Person_evidence | WBPerson83 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_II | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | qua-1 | Person_evidence | WBPerson83 | |||||
| Sequence_name | T05C12.10 | ||||||||
| Molecular_name | T05C12.10 | ||||||||
| T05C12.10.1 | |||||||||
| CE34989 | |||||||||
| Other_name | CELE_T05C12.10 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | qua-1 | ||||||||
| DB_info | Database | AceView | gene | 2I493 | |||||
| WormQTL | gene | WBGene00004264 | |||||||
| WormFlux | gene | WBGene00004264 | |||||||
| NDB | locus_tag | CELE_T05C12.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004264|UniProtKB=G5EC21 | |||||||
| family | PTHR46706 | ||||||||
| NCBI | gene | 174319 | |||||||
| RefSeq | protein | NM_063324.5 | |||||||
| SwissProt | UniProtAcc | G5EC21 | |||||||
| TREEFAM | TREEFAM_ID | TF106458 | |||||||
| UniProt_GCRP | UniProtAcc | G5EC21 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | qua | ||||||||
| Allele | WBVar01499702 | ||||||||
| WBVar00226133 | |||||||||
| WBVar00226134 | |||||||||
| WBVar01498435 | |||||||||
| WBVar01695764 | |||||||||
| WBVar01538316 | |||||||||
| WBVar01538317 | |||||||||
| WBVar00145487 | |||||||||
| WBVar01604266 | |||||||||
| WBVar02002852 | |||||||||
| WBVar01604267 | |||||||||
| WBVar01498097 | |||||||||
| WBVar00371702 | |||||||||
| WBVar00371703 | |||||||||
| WBVar00371704 | |||||||||
| WBVar00371705 | |||||||||
| WBVar00371706 | |||||||||
| WBVar00371707 | |||||||||
| WBVar00371708 | |||||||||
| WBVar00371709 | |||||||||
| WBVar00371710 | |||||||||
| WBVar00371711 | |||||||||
| WBVar00371712 | |||||||||
| WBVar00371713 | |||||||||
| WBVar00371714 | |||||||||
| WBVar00173923 | |||||||||
| WBVar00104628 | |||||||||
| WBVar00104629 | |||||||||
| WBVar01500174 | |||||||||
| WBVar00748751 | |||||||||
| WBVar00748752 | |||||||||
| WBVar00748753 | |||||||||
| WBVar00748754 | |||||||||
| WBVar00748755 | |||||||||
| WBVar00748756 | |||||||||
| WBVar00748757 | |||||||||
| WBVar00748758 | |||||||||
| WBVar00748759 | |||||||||
| WBVar00748760 | |||||||||
| WBVar00748761 | |||||||||
| WBVar00748762 | |||||||||
| WBVar00748763 | |||||||||
| WBVar00748764 | |||||||||
| WBVar00748765 | |||||||||
| WBVar00748766 | |||||||||
| WBVar00748767 | |||||||||
| WBVar00748768 | |||||||||
| WBVar01685346 | |||||||||
| WBVar00748769 | |||||||||
| WBVar00748770 | |||||||||
| WBVar00748771 | |||||||||
| WBVar00748772 | |||||||||
| WBVar00748773 | |||||||||
| WBVar00748774 | |||||||||
| WBVar00748775 | |||||||||
| WBVar00748776 | |||||||||
| WBVar00748777 | |||||||||
| WBVar00748778 | |||||||||
| WBVar00748779 | |||||||||
| WBVar00748780 | |||||||||
| WBVar00748781 | |||||||||
| WBVar00748782 | |||||||||
| WBVar00748783 | |||||||||
| WBVar00748784 | |||||||||
| WBVar00748785 | |||||||||
| WBVar00748786 | |||||||||
| WBVar02130340 | |||||||||
| WBVar02130341 | |||||||||
| WBVar01498940 | |||||||||
| WBVar02151769 | |||||||||
| Strain | WBStrain00002356 | ||||||||
| WBStrain00035500 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (31) | |||||||||
| Paralog (24) | |||||||||
| Structured_description | Concise_description | qua-1 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, a Qua domain, a 5W repeat, an extended region oflow-complexity sequence, and a Hint/Hog domain; QUA-1 is conserved amongnematodes from Caenorhabditis to Brugia; QUA-1 is expressed prior tomolting in hyp1 to hyp11 hypodermal cells, but not in seam cells, andceases to be expressed after each molting cycle or in gravid adults nolonger molting; QUA-1 is strongly required for normal molting, withlethal molting defects in qua-1 mutants and severe defects inqua-1(RNAi) animals; similar molting defects in RNAi of ptr-4 and ptr-23(encoding Dispatched homologs) suggest that PTR-4 and PTR-23 may exportQUA-1 from hypodermal cells synthesizing it; other sites of QUA-1expression include intestinal and rectal cells, excretory duct and porecells, sensilla support cells, the P cell lineage in L1, body wallmuscle, and the adult reproductive system; QUA-1 is also required fornormal adult alae formation, growth to full size, cuticle adhesion,locomotion, and male tail development; the Hint/Hog domain is predictedto cut QUA-1 into two halves and then covalently link cholesterol to theC-terminus of the Qua domain; the Qua domain is predicted to form acysteine-crosslinked protein involved in intercellular signalling, andthe Qua domain has subtle similarity to the N-terminal Hedge domain ofHEDGEHOG proteins; both Qua and Hint/Hog domains are required fortransgenic rescue of a lethal qua-1 allele; defects in both qua-1mutants and qua-1(RNAi) animals; all of QUA-1's functions may reflectcommon defects in cholesterol-dependent hedgehog-like signalling. | Paper_evidence | WBPaper00003717 | |||||
| WBPaper00006525 | |||||||||
| WBPaper00026763 | |||||||||
| WBPaper00026841 | |||||||||
| WBPaper00027129 | |||||||||
| WBPaper00027263 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 05 Nov 2006 00:00:00 | ||||||||
| Automated_description | Involved in molting cycle and nematode larval development. Acts upstream of or within nematode male tail mating organ morphogenesis. Located in collagen and cuticulin-based cuticle extracellular matrix. Expressed in several structures, including P1; P12; P2; excretory system; and hypodermal cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T05C12.10 | |||||||
| Corresponding_CDS_history | T05C12.10:wp106 | ||||||||
| Corresponding_transcript | T05C12.10.1 | ||||||||
| Other_sequence (40) | |||||||||
| Associated_feature | WBsf657206 | ||||||||
| WBsf657945 | |||||||||
| WBsf988670 | |||||||||
| WBsf988671 | |||||||||
| WBsf1012657 | |||||||||
| WBsf1012658 | |||||||||
| WBsf221705 | |||||||||
| WBsf221706 | |||||||||
| Experimental_info | RNAi_result (33) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00002958 | ||||||||
| WBCnstr00004471 | |||||||||
| WBCnstr00006893 | |||||||||
| WBCnstr00011601 | |||||||||
| WBCnstr00011933 | |||||||||
| WBCnstr00015885 | |||||||||
| WBCnstr00035603 | |||||||||
| Construct_product | WBCnstr00015885 | ||||||||
| WBCnstr00035603 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (324) | |||||||||
| Interaction (169) | |||||||||
| WBProcess | WBbiopr:00000123 | ||||||||
| Map_info | Map | II | Position | 0.749646 | Error | 0.000106 | |||
| Positive | Positive_clone | T05C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4617 | |||||||
| Pseudo_map_position | |||||||||
| Reference (18) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
