WormBase Tree Display for Gene: WBGene00003175

WBGene00003175 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 1
    Name: CGC_name: mec-12 Person_evidence: WBPerson95
      Sequence_name: C44B11.3
      Molecular_name: C44B11.3
        C44B11.3.1
        CE24843
      Other_name: tba-3
        Alpha-tubulin Accession_evidence: EMBL D21134
        CELE_C44B11.3 Accession_evidence: NDB BX284603
      Public_name: mec-12
    DB_info: Database: AceView gene 3E222
        WormQTL gene WBGene00003175
        WormFlux gene WBGene00003175
        NDB locus_tag CELE_C44B11.3
        Panther gene CAEEL|WormBase=WBGene00003175|UniProtKB=P91910
          family PTHR11588
        NCBI gene 175419
        RefSeq protein NM_065262.6
        KEGG KEGG_id 3.6.5.-
        NemaPath KEGG_id 3.6.5.-
        SwissProt UniProtAcc P91910
        UniProt_GCRP UniProtAcc P91910
        OMIM gene 191110
            602529
            617878
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (11)
  Disease_info: Potential_model: DOID:11832 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20766)
      DOID:10126 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:24071)
      DOID:0112232 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20766)
      DOID:0050453 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20766)
      DOID:10907 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20766)
      DOID:0060355 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12407)
      DOID:14250 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20766)
  Molecular_info: Corresponding_CDS: C44B11.3
    Corresponding_transcript: C44B11.3.1
    Other_sequence (161)
    Associated_feature (12)
  Experimental_info: RNAi_result: WBRNAi00068743 Inferred_automatically: RNAi_primary
      WBRNAi00027703 Inferred_automatically: RNAi_primary
      WBRNAi00011904 Inferred_automatically: RNAi_primary
      WBRNAi00117198 Inferred_automatically: RNAi_primary
      WBRNAi00006557 Inferred_automatically: RNAi_primary
      WBRNAi00068805 Inferred_automatically: RNAi_primary
      WBRNAi00076212 Inferred_automatically: RNAi_primary
      WBRNAi00042413 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram511
      Expr1269
      Expr4856
      Expr5493
      Expr16375
      Expr1022948
      Expr1031506
      Expr1146401
      Expr2013489
      Expr2031723
    Drives_construct: WBCnstr00002356
      WBCnstr00005976
      WBCnstr00005978
      WBCnstr00009413
      WBCnstr00009414
      WBCnstr00009415
      WBCnstr00010183
      WBCnstr00012284
      WBCnstr00042980
    Construct_product: WBCnstr00005975
      WBCnstr00005976
      WBCnstr00005978
      WBCnstr00009413
      WBCnstr00009414
      WBCnstr00009415
      WBCnstr00010183
    Antibody: WBAntibody00001691
    Microarray_results (17)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00035269:cde-1_regulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:insoluble_protein
      WBPaper00037946:LIN-39_interacting
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040420:ALM_PLM_enriched
      WBPaper00040420:FLP_enriched
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044246:pgrn-1_ced-1_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046121:ecdoderm_unique
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046795:starvation_upregulated
      WBPaper00046858:elt-2(RNAi)_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050234:lin-28(RNAi)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050698:DEP-1_interacting
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051461:pig-1(gm344)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055103:thoc-5(wy822)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:male-tail_expressed
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055897:heat-shock_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057347:nhr-14(tm1473)_downreglated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059254:CSR-1_interacting
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi)
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061210:huIs179_upregulated
      WBPaper00061340:ALA
      WBPaper00061340:ALM_BDU
      WBPaper00061340:ALM_PLM
      WBPaper00061340:ALN
      WBPaper00061340:AVA
      WBPaper00061340:AVB
      WBPaper00061340:AVD
      WBPaper00061340:AVE
      WBPaper00061340:AVH
      WBPaper00061340:AVJ
      WBPaper00061340:AVK
      WBPaper00061340:AVL
      WBPaper00061340:DVA
      WBPaper00061340:FLP
      WBPaper00061340:I5
      WBPaper00061340:M4_parent
      WBPaper00061340:MC
      WBPaper00061340:NSM_parent
      WBPaper00061340:OLL_parent
      WBPaper00061340:OLQ
      WBPaper00061340:OLQ_grandparent
      WBPaper00061340:OLQ_parent
      WBPaper00061340:PLM
      WBPaper00061340:PLM_ALN_grandparent
      WBPaper00061340:PVP
      WBPaper00061340:RID
      WBPaper00061340:RIV
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061466:nath-10(icb99)_downregulated
      WBPaper00061466:nath-10(icb102)_downregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:mtd-1-mec-18
      WBPaper00061651:ALA_enriched
      WBPaper00061651:ALM_enriched
      WBPaper00061651:AVA_enriched
      WBPaper00061651:AVB_enriched
      WBPaper00061651:AVD_enriched
      WBPaper00061651:AVE_enriched
      WBPaper00061651:AVH_enriched
      WBPaper00061651:AVJ_enriched
      WBPaper00061651:AVL_enriched
      WBPaper00061651:AVM_enriched
      WBPaper00061651:CAN_enriched
      WBPaper00061651:DA9_enriched
      WBPaper00061651:DA_enriched
      WBPaper00061651:DB01_enriched
      WBPaper00061651:DB_enriched
      WBPaper00061651:DVA_enriched
      WBPaper00061651:DVC_enriched
      WBPaper00061651:HSN_enriched
      WBPaper00061651:OLQ_enriched
      WBPaper00061651:PLM_enriched
      WBPaper00061651:PVC_enriched
      WBPaper00061651:PVM_enriched
      WBPaper00061651:PVR_enriched
      WBPaper00061651:PVT_enriched
      WBPaper00061651:PVW_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:VA12_enriched
      WBPaper00061651:VA_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061651:VB_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062167:mbl-1(tm1563)_downregulated
      WBPaper00062197:TRN_enriched
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_downregulated_protein
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064201:SNA-1_interacting
      WBPaper00064257:UNG-1_interacting
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064992:Capsaicin_downregulated
      WBPaper00064992:Eugenol_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:67
      WBPaper00065623:154
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:20_0
      WBPaper00065841:20_1
      WBPaper00065841:20_2
      WBPaper00065841:28_0
      WBPaper00065841:49_0
      WBPaper00065841:54_0
      WBPaper00065841:60_0
      WBPaper00065841:75_0
      WBPaper00065841:98_0
      WBPaper00065841:103_0
      WBPaper00065841:137_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_1_6
      cgc4489_group_20
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Larval_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_C
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_3h
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      [cgc6390]:Cluster_B
      [cgc6390]:male_sex-enriched
    Interaction (315)
  Map_info: Map: III Position: -7.49759 Error: 0.038654
    Well_ordered
    Positive: Positive_clone: C44B11 Inferred_automatically: From sequence, transcript, pseudogene data
        C56F12
    Mapping_data: 2_point: 496
        1607
        4698
      Multi_point: 425
        857
        1579
        1626
        1627
        1879
        2039
        2439
        4017
      Pos_neg_data: 6855
    Landmark_gene
  Reference (87)
  Method: Gene