WormBase Tree Display for Gene: WBGene00006769
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WBGene00006769 | SMap | S_parent | Sequence | Y37E11C | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143034 | ||||||
Allele (224) | |||||||
Possibly_affected_by | WBVar02156987 | ||||||
Legacy_information | e204 : very slow almost paralysed tends to curl dumpyish; weak FITC uptake; amphid phasmid PDE axons abnormal; abnormal neuronal microtubules. ES3 ME0. NA5 (e572 e735). | ||||||
See also e572, e1193, e1261, e1358 | |||||||
[C.elegansII] e204 : very slow, almost paralysed; tends to curl; dumpyish; weak FITC uptake; amphid, phasmid, PDE, PVP axons abnormal; multiple defects in axonogenesis; abnormally abundant neuronal microtubules. ES3 ME0. OA>10: e572, e735, e1358, m7,mn260::Tc4, rh1030::Tc4, etc. Cloned: 2.8, 3.3, 3.8 kb transcripts (different 5' ends) encoding predicted 523 aa, 679 aa, 854 aa proteins with similarity to collapsin??? Antibody stains all neuron processes in larvae and adults. [Hedgecock et al. 1985; Li et al. 1992; EH; SP] | |||||||
[Li W] mn260 is Tc4 insertion in exon VII of longest (3.8kb) unc-33 transcript. rh1030 same insertion site, modified Tc4 element. | |||||||
Strain (29) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (28) | |||||||
Contained_in_operon | CEOP4092 | ||||||
Ortholog (37) | |||||||
Paralog | WBGene00000963 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00000964 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | unc-33 encodes a conserved member of the CRMP/TOAD/Ulip/DRP family of proteins that includes mammalian CRMP-2 (Collapsin response mediator protein-2), which is essential for axon guidance and axonogenesis; in C. elegans, unc-33 activity is required for several biological processes including outgrowth and guidance of sensory, motor, and interneurons, sex myoblast migration, normal body movement and morphology, egg laying, and defecation; by homology to CRMP-2, UNC-33 is predicted to bind tubulin heterodimers and promote microtubule assembly, thereby regulating the extension and branching of cellular projections during neuronal polarization; UNC-33 is reportedly expressed exclusively in axonal processes from after early embryogenesis through larval and adult stages. | Paper_evidence | WBPaper00001622 | |||
WBPaper00002665 | |||||||
WBPaper00004362 | |||||||
WBPaper00010044 | |||||||
WBPaper00025204 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 06 Jun 2005 00:00:00 | ||||||
Automated_description | Enables filamin binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including axon guidance; establishment or maintenance of cytoskeleton polarity; and regulation of locomotion. Located in neuron projection. Expressed in amphid socket cell; neuroblasts; neurons; pharyngeal cell; and somatic nervous system. Is an ortholog of human DPYSL2 (dihydropyrimidinase like 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | Y37E11C.1a | |||||
Y37E11C.1b | |||||||
Y37E11C.1c | |||||||
Corresponding_CDS_history | Y37E11C.1:wp82 | ||||||
Y37E11C.1a:wp145 | |||||||
Y37E11C.1b:wp145 | |||||||
Y37E11C.1c:wp145 | |||||||
Y37E11C.1c:wp273 | |||||||
Corresponding_transcript | Y37E11C.1a.1 | ||||||
Y37E11C.1b.1 | |||||||
Y37E11C.1c.1 | |||||||
Other_sequence (38) | |||||||
Associated_feature (12) | |||||||
Experimental_info | RNAi_result | WBRNAi00103588 | Inferred_automatically | RNAi_primary | |||
WBRNAi00020239 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086120 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00055925 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00055924 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089774 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090316 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00030274 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090157 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089998 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram1378 | ||||||
Expr3751 | |||||||
Expr4828 | |||||||
Expr12912 | |||||||
Expr15036 | |||||||
Expr1010879 | |||||||
Expr1032842 | |||||||
Expr1159445 | |||||||
Expr2017866 | |||||||
Expr2036002 | |||||||
Marker119 | |||||||
Drives_construct | WBCnstr00001590 | ||||||
WBCnstr00001591 | |||||||
WBCnstr00006869 | |||||||
Construct_product (15) | |||||||
Antibody | WBAntibody00000953 | ||||||
WBAntibody00000954 | |||||||
WBAntibody00001546 | |||||||
WBAntibody00001788 | |||||||
WBAntibody00001922 | |||||||
WBAntibody00002299 | |||||||
Microarray_results (28) | |||||||
Expression_cluster (148) | |||||||
Interaction | WBInteraction000000929 | ||||||
WBInteraction000002995 | |||||||
WBInteraction000030273 | |||||||
WBInteraction000031515 | |||||||
WBInteraction000126300 | |||||||
WBInteraction000126781 | |||||||
WBInteraction000140677 | |||||||
WBInteraction000147758 | |||||||
WBInteraction000157625 | |||||||
WBInteraction000157626 | |||||||
WBInteraction000161585 | |||||||
WBInteraction000165647 | |||||||
WBInteraction000166395 | |||||||
WBInteraction000182081 | |||||||
WBInteraction000186198 | |||||||
WBInteraction000186437 | |||||||
WBInteraction000197740 | |||||||
WBInteraction000197744 | |||||||
WBInteraction000197745 | |||||||
WBInteraction000197746 | |||||||
WBInteraction000203016 | |||||||
WBInteraction000209322 | |||||||
WBInteraction000215192 | |||||||
WBInteraction000215207 | |||||||
WBInteraction000216460 | |||||||
WBInteraction000227690 | |||||||
WBInteraction000233883 | |||||||
WBInteraction000244298 | |||||||
WBInteraction000268346 | |||||||
WBInteraction000281209 | |||||||
WBInteraction000293895 | |||||||
WBInteraction000298990 | |||||||
WBInteraction000309146 | |||||||
WBInteraction000309147 | |||||||
WBInteraction000321439 | |||||||
WBInteraction000330814 | |||||||
WBInteraction000330906 | |||||||
WBInteraction000356816 | |||||||
WBInteraction000365455 | |||||||
WBInteraction000376228 | |||||||
WBInteraction000387318 | |||||||
WBInteraction000401780 | |||||||
WBInteraction000401852 | |||||||
WBInteraction000422858 | |||||||
WBInteraction000464856 | |||||||
WBInteraction000471266 | |||||||
WBInteraction000473612 | |||||||
WBInteraction000505174 | |||||||
WBInteraction000505175 | |||||||
WBInteraction000524786 | |||||||
WBInteraction000535491 | |||||||
WBInteraction000535493 | |||||||
WBInteraction000535495 | |||||||
WBInteraction000535496 | |||||||
WBInteraction000535498 | |||||||
WBInteraction000540060 | |||||||
WBInteraction000540336 | |||||||
WBInteraction000540365 | |||||||
WBInteraction000540366 | |||||||
WBInteraction000543327 | |||||||
WBInteraction000553318 | |||||||
WBInteraction000554840 | |||||||
WBInteraction000555692 | |||||||
WBInteraction000567117 | |||||||
WBInteraction000567554 | |||||||
WBInteraction000568455 | |||||||
WBInteraction000569521 | |||||||
WBInteraction000583885 | |||||||
WBInteraction000584170 | |||||||
WBProcess | WBbiopr:00000010 | ||||||
Map_info | Map | IV | Position | -3.30458 | Error | 0.013709 | |
Well_ordered | |||||||
Positive | Inside_rearr | mDp4 | |||||
Positive_clone | EH#143 | ||||||
Y37E11 | |||||||
Y37E11C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 99 | |||||
484 | |||||||
824 | |||||||
1643 | |||||||
3276 | |||||||
Multi_point (15) | |||||||
Pos_neg_data | 9110 | ||||||
Reference (123) | |||||||
Remark | extracted from Li et al. (1992) | ||||||
sequence match was given and M57.b and.c but theses overlap with Y37E11C.c which has not been annotated yet. sdm 11/00. will probably acquire name Y37E11C.1 | |||||||
Method | Gene |