WormBase Tree Display for Gene: WBGene00006868
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WBGene00006868 | SMap | S_parent | Sequence | M03A1 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | vab-1 | Person_evidence | WBPerson261 | |||||
Sequence_name | M03A1.1 | ||||||||
Molecular_name | M03A1.1 | ||||||||
M03A1.1.1 | |||||||||
CE25060 | |||||||||
Other_name | CELE_M03A1.1 | Accession_evidence | NDB | BX284602 | |||||
Public_name | vab-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | vab | ||||||||
Reference_allele | WBVar00142901 | ||||||||
Allele (418) | |||||||||
Legacy_information | e2 : notched head variable dystrophy of ventral cephalic region especially in L1; penetrance < 70%. ES3/0 ME3. NA8 (e1063 : penetrance 35%; e2027spo : penetrance > 90%). | ||||||||
See also e2, e116, e118, e200, e699, e721, e1063, e2027 | |||||||||
[C.elegansII] e2 : notched head, variable dystrophy of ventral cephalic region, especially in L1; penetrance < 70%. ES3/0 ME3. OA>10: e1063 (penetrance 35%), e2027spo (penetrance > 90%), e699 etc. [Brenner 1974; Lewis and Hodgkin 1979; CB; CZ] | |||||||||
Strain (24) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (38) | |||||||||
Ortholog (113) | |||||||||
Paralog (69) | |||||||||
Structured_description | Concise_description | vab-1 encodes an ephrin receptor; during development, vab-1 activity is required for neural and epithelial morphogenesis as well as for proper axon targeting and neuronal cell migration; in addition, VAB-1 functions as a major sperm protein receptor in a sperm-sensing control mechanism that regulates oocyte meiotic maturation; VAB-1::GFP reporters are expressed in neuronal cells and in oocytes and sheath cells of the proximal gonad. | Paper_evidence | WBPaper00003020 | |||||
WBPaper00003843 | |||||||||
WBPaper00005670 | |||||||||
WBPaper00027013 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 28 Feb 2007 00:00:00 | ||||||||
Automated_description | Enables ephrin receptor activity and protein domain specific binding activity. Involved in several processes, including cell development; embryonic morphogenesis; and regulation of axon guidance. Located in axon and plasma membrane. Expressed in several structures, including hypodermal cell; neuroblasts; neurons; oocyte; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; aortic dissection; cataract 6 multiple types; and gastrointestinal system cancer (multiple). Is an ortholog of several human genes including EPHB1 (EPH receptor B1); EPHB2 (EPH receptor B2); and EPHB3 (EPH receptor B3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (14) | ||||||||
Molecular_info | Corresponding_CDS | M03A1.1 | |||||||
Corresponding_CDS_history | M03A1.1b:wp274 | ||||||||
Corresponding_transcript | M03A1.1.1 | ||||||||
Other_sequence (11) | |||||||||
Associated_feature (54) | |||||||||
Experimental_info | RNAi_result (27) | ||||||||
Expr_pattern | Expr1107 | ||||||||
Expr1439 | |||||||||
Expr2306 | |||||||||
Expr3782 | |||||||||
Expr8095 | |||||||||
Expr8834 | |||||||||
Expr9971 | |||||||||
Expr10006 | |||||||||
Expr11226 | |||||||||
Expr12575 | |||||||||
Expr1021751 | |||||||||
Expr1032910 | |||||||||
Expr1154537 | |||||||||
Expr1170053 | |||||||||
Expr2017948 | |||||||||
Expr2036084 | |||||||||
Drives_construct | WBCnstr00000707 | ||||||||
WBCnstr00006419 | |||||||||
WBCnstr00009616 | |||||||||
WBCnstr00018076 | |||||||||
WBCnstr00034120 | |||||||||
WBCnstr00042438 | |||||||||
Construct_product (15) | |||||||||
Antibody | WBAntibody00000876 | ||||||||
WBAntibody00001049 | |||||||||
WBAntibody00001576 | |||||||||
WBAntibody00002037 | |||||||||
WBAntibody00002313 | |||||||||
Microarray_results | SMD_M03A1.1 | ||||||||
175372_s_at | |||||||||
193384_at | |||||||||
A_12_P113912 | |||||||||
Aff_M03A1.1 | |||||||||
GPL13394_WBGene00006868 | |||||||||
GPL13914_M03A1.1 | |||||||||
GPL14144_M03A1.1b_2409-2468_0.892_11_C | |||||||||
GPL14144_M03A1.1b_2494-2553_0.895_9_B | |||||||||
GPL14144_M03A1.1b_2693-2752_0.911_3_A | |||||||||
GPL19516_CGZ0029797 | |||||||||
GPL19516_CGZ0029798 | |||||||||
GPL21109_M03A1.1a | |||||||||
GPL3518_CE28617 | |||||||||
GPL8304_CE_WBGene00006868_A | |||||||||
GPL8304_CE_WBGene00006868_B | |||||||||
GPL8304_CE_WBGene00006868_C | |||||||||
GPL8673_M03A1_1aP02108 | |||||||||
GPL8673_M03A1_1aP02981 | |||||||||
GPL8673_M03A1_1aP03206 | |||||||||
GPL8673_M03A1_1bP02108 | |||||||||
GPL8673_M03A1_1bP02996 | |||||||||
GPL8673_M03A1_1bP03221 | |||||||||
GPL9450_M03A1.1a | |||||||||
GPL9450_M03A1.1b | |||||||||
cea2.d.33978 | |||||||||
cea2.d.33983 | |||||||||
cea2.p.43337 | |||||||||
Expression_cluster (158) | |||||||||
Interaction (248) | |||||||||
Anatomy_function | WBbtf0217 | ||||||||
WBbtf0220 | |||||||||
WBProcess | WBbiopr:00000001 | ||||||||
WBbiopr:00000068 | |||||||||
WBbiopr:00000120 | |||||||||
Map_info | Map | II | Position | -3.85469 | Error | 0.013028 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | mDf14 | |||||||
mDf15 | |||||||||
Positive_clone | M03A1 | Person_evidence | WBPerson105 | ||||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Mapping_data | 2_point | 266 | |||||||
Multi_point | 48 | ||||||||
881 | |||||||||
882 | |||||||||
1880 | |||||||||
4031 | |||||||||
4032 | |||||||||
Pos_neg_data (12) | |||||||||
Reference (154) | |||||||||
Method | Gene |