| WBGene00006605 | SMap | S_parent | Sequence | CHROMOSOME_II |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | tra-2 | Person_evidence | WBPerson261 |
| | | Sequence_name | C15F1.3 |
| | | Molecular_name | C15F1.3a |
| | | | C15F1.3a.1 |
| | | | CE23546 |
| | | | C15F1.3b |
| | | | CE23547 |
| | | | C15F1.3c |
| | | | CE43762 |
| | | | C15F1.3b.1 |
| | | | C15F1.3c.1 |
| | | Other_name | CELE_C15F1.3 | Accession_evidence | NDB | BX284602 |
| | | Public_name | tra-2 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | tra |
| | Reference_allele | WBVar00143737 |
| | Allele (200) |
| | Legacy_information | e1095sd : XX animals transformed into infertile males with abnormal tail anatomy; gonad morphology male normal spermatogenesis; XO phenotype wildtype male; e1095/+ is Egl hermaphrodite. ES3 ME3 (XO) ME0 (XX). NA (recessive) > 20 (e1425amber (resembles e1095); f70 (masculinized self-fertile hermaphrodite) e1875 (slightly Egl hermaphrodite very weak allele) b202ts : self-fertile hermaphrodite at 16x Tra-2 at 25x) etc.). Also Class 2 (gain-of-function) alleles e2020dm : XX animals completely feminized XO animals fertile males slightly feminized. NA (dominant) 6 : most are weaker than e2020. Also intragneic revertants of dominants resemble Class 1 alleles. NA > 10. |
| | | See also e1209, e1403, e1476, e1839, e1854, e1875, e1939, e1940, e1941, e2019, e2020, e2021, e2022, e2023, e2024, e2025, e2026, e2029, e2046, e2047, e2048, e2049, e2050, e2051, e2052, e2053, e2054, e2113, e2114, e2115, e2116, n196, n1106 |
| | | [C.elegansII] e1095sd : XX animals transformed into infertile males with abnormal tail anatomy; gonad morphology male, normal spermatogenesis; XO phenotype wildtype male; e1095/+ is Egl hermaphrodite. Probable null phenotype. ES3 ME3 (XO) ME0 (XX). OA>20 (recessive): e1425amb (resembles e1095); q276 (XX animals transformed into mating males, anomalous non-null);f70 (masculinized self-fertile hermaphrodite), e1875 (slightly Egl hermaphrodite, very weak allele), b202ts (self-fertile hermaphrodite at 16C, Tra-2 at 25C) etc. Also hypermorphic gf alleles: e2020dm (XX animals completely feminized, XO animals fertile males, slightly feminized;e2020/+ XX also female). OA>6 (hypermorphic):e2046 etc. (all weaker than e2020). Also constitutive gf alleles: e2531dm(e2531 and e531/+ XO animals hermaphrodite, no effect on XX). OA9 (consititutive): all resemble e2531. Intragenic revertants of both gf types are lf (XX masculinizing). Also mixed effect alleles: e1941, e2021(dominant feminizing effect on XX germline,recessive weak masculinization of XX soma). Cloned: 1.8, 1.9, 4.7 kb transcripts; largest encodes 1475 aa TRA-2A protein, nine TM domains.Complex regulation and expression. Downstream gene in operon with ppp-1. [Klass et al. 1976; Doniach 1986; Kuwabaraet al. 1992; Kuwabara 1996; BG; CB; JK; PK] |
| | Strain (28) |
| | RNASeq_FPKM (74) |
| | GO_annotation (38) |
| | Contained_in_operon | CEOP2268 |
| | Ortholog (19) |
| | Paralog | WBGene00044213 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00006965 | Caenorhabditis elegans | From_analysis | Panther |
| | Structured_description | Concise_description | tra-2 encodes a transmembrane receptor that functions in the sex determination pathway to specify female fates in hermaphroditic XX animals; tra-2 encodes two proteins: TRA-2A, the major protein expressed at all developmental stages, and TRA-2B, a form specific to the hermaphrodite germ line; in hermaphrodites, direct interaction between the TRA-2A intracellular domain inhibits FEM-3 masculinizing activity, whereas in males, TRA-2A is negatively regulated by HER-1, allowing the FEM proteins to specify male development; TRA-2A localizes to the plasma membrane where its activity is positively regulated, in part, by proteolytic cleavage by the TRA-3 calpain-like protease. | Paper_evidence | WBPaper00001553 |
| | | | | | WBPaper00002283 |
| | | | | | WBPaper00003569 |
| | | | | | WBPaper00003993 |
| | | | | | WBPaper00004113 |
| | | | | | WBPaper00004480 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 09 Apr 2007 00:00:00 |
| | | Automated_description | Enables transmembrane signaling receptor activity. Involved in developmental process involved in reproduction and oocyte fate determination. Located in nucleus; perinuclear region of cytoplasm; and plasma membrane. Expressed in germ line. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C15F1.3a |
| | | C15F1.3b |
| | | C15F1.3c |
| | Corresponding_transcript | C15F1.3a.1 |
| | | C15F1.3b.1 |
| | | C15F1.3c.1 |
| | Associated_feature (14) |
| Experimental_info | RNAi_result (15) |
| | Expr_pattern | Expr1054 |
| | | Expr1519 |
| | | Expr3832 |
| | | Expr1029136 |
| | | Expr1032736 |
| | | Expr1144665 |
| | | Expr2017476 |
| | | Expr2035615 |
| | Drives_construct | WBCnstr00007548 |
| | | WBCnstr00007550 |
| | | WBCnstr00007552 |
| | | WBCnstr00007553 |
| | | WBCnstr00011683 |
| | | WBCnstr00034275 |
| | Construct_product | WBCnstr00007552 |
| | | WBCnstr00007553 |
| | | WBCnstr00010052 |
| | | WBCnstr00011683 |
| | | WBCnstr00034275 |
| | Antibody | WBAntibody00000899 |
| | | WBAntibody00001172 |
| | | WBAntibody00001580 |
| | | WBAntibody00001828 |
| | Microarray_results (29) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00035211:age-1_vs_age-1_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00042561:smgl-1(RNAi)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049736:15deg-then-25deg(12hr)_downregulated_N2 |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059754:C.neoformans_H99_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:AVH_parent |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061527:lpd-2-EEED8.16 |
| | | WBPaper00061527:R07E4.5-skp-1_1608 |
| | | WBPaper00062095:unc-4(e120)_upregulated_VA-neuron |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00064502:spe-44(fx110)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00025032:cluster_57 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00037611:GLD-2-associated |
| | | WBPaper00037611:RNP-8-associated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042258:DA1877_downregulated_GravidAdult |
| | | WBPaper00042274:tbx-2(bx59)_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc6390]:Cluster_F |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction | WBInteraction000000014 |
| | | WBInteraction000000017 |
| | | WBInteraction000000033 |
| | | WBInteraction000000054 |
| | | WBInteraction000000055 |
| | | WBInteraction000000149 |
| | | WBInteraction000000152 |
| | | WBInteraction000000153 |
| | | WBInteraction000000212 |
| | | WBInteraction000000225 |
| | | WBInteraction000000269 |
| | | WBInteraction000000270 |
| | | WBInteraction000000274 |
| | | WBInteraction000000311 |
| | | WBInteraction000000314 |
| | | WBInteraction000000315 |
| | | WBInteraction000000413 |
| | | WBInteraction000000414 |
| | | WBInteraction000000415 |
| | | WBInteraction000000738 |
| | | WBInteraction000000790 |
| | | WBInteraction000000794 |
| | | WBInteraction000000842 |
| | | WBInteraction000000879 |
| | | WBInteraction000001025 |
| | | WBInteraction000001060 |
| | | WBInteraction000001290 |
| | | WBInteraction000001294 |
| | | WBInteraction000001319 |
| | | WBInteraction000001385 |
| | | WBInteraction000001462 |
| | | WBInteraction000001482 |
| | | WBInteraction000001541 |
| | | WBInteraction000001582 |
| | | WBInteraction000001583 |
| | | WBInteraction000001584 |
| | | WBInteraction000001883 |
| | | WBInteraction000001887 |
| | | WBInteraction000002386 |
| | | WBInteraction000002515 |
| | | WBInteraction000002517 |
| | | WBInteraction000002520 |
| | | WBInteraction000002523 |
| | | WBInteraction000002524 |
| | | WBInteraction000002525 |
| | | WBInteraction000002527 |
| | | WBInteraction000002530 |
| | | WBInteraction000002811 |
| | | WBInteraction000002812 |
| | | WBInteraction000003118 |
| | | WBInteraction000003119 |
| | | WBInteraction000003203 |
| | | WBInteraction000003204 |
| | | WBInteraction000003240 |
| | | WBInteraction000003305 |
| | | WBInteraction000003675 |
| | | WBInteraction000003676 |
| | | WBInteraction000003677 |
| | | WBInteraction000003781 |
| | | WBInteraction000003915 |
| | | WBInteraction000003926 |
| | | WBInteraction000004537 |
| | | WBInteraction000004900 |
| | | WBInteraction000004903 |
| | | WBInteraction000005269 |
| | | WBInteraction000005382 |
| | | WBInteraction000005383 |
| | | WBInteraction000005385 |
| | | WBInteraction000005386 |
| | | WBInteraction000005387 |
| | | WBInteraction000005667 |
| | | WBInteraction000005675 |
| | | WBInteraction000005676 |
| | | WBInteraction000006696 |
| | | WBInteraction000006758 |
| | | WBInteraction000006768 |
| | | WBInteraction000007208 |
| | | WBInteraction000007324 |
| | | WBInteraction000008954 |
| | | WBInteraction000008955 |
| | | WBInteraction000009237 |
| | | WBInteraction000009943 |
| | | WBInteraction000028354 |
| | | WBInteraction000028628 |
| | | WBInteraction000029233 |
| | | WBInteraction000029276 |
| | | WBInteraction000029339 |
| | | WBInteraction000030369 |
| | | WBInteraction000030541 |
| | | WBInteraction000030556 |
| | | WBInteraction000030847 |
| | | WBInteraction000031159 |
| | | WBInteraction000031266 |
| | | WBInteraction000031453 |
| | | WBInteraction000031690 |
| | | WBInteraction000031697 |
| | | WBInteraction000031856 |
| | | WBInteraction000031857 |
| | | WBInteraction000050595 |
| | | WBInteraction000052137 |
| | | WBInteraction000052144 |
| | | WBInteraction000052147 |
| | | WBInteraction000052158 |
| | | WBInteraction000052159 |
| | | WBInteraction000052160 |
| | | WBInteraction000052161 |
| | | WBInteraction000052162 |
| | | WBInteraction000052163 |
| | | WBInteraction000052164 |
| | | WBInteraction000052277 |
| | | WBInteraction000052278 |
| | | WBInteraction000052279 |
| | | WBInteraction000126153 |
| | | WBInteraction000126287 |
| | | WBInteraction000126288 |
| | | WBInteraction000126289 |
| | | WBInteraction000126843 |
| | | WBInteraction000127209 |
| | | WBInteraction000127515 |
| | | WBInteraction000133471 |
| | | WBInteraction000165806 |
| | | WBInteraction000166355 |
| | | WBInteraction000166356 |
| | | WBInteraction000166357 |
| | | WBInteraction000166358 |
| | | WBInteraction000166359 |
| | | WBInteraction000166360 |
| | | WBInteraction000166361 |
| | | WBInteraction000166362 |
| | | WBInteraction000184450 |
| | | WBInteraction000184451 |
| | | WBInteraction000184452 |
| | | WBInteraction000184453 |
| | | WBInteraction000184454 |
| | | WBInteraction000216666 |
| | | WBInteraction000216667 |
| | | WBInteraction000247641 |
| | | WBInteraction000303807 |
| | | WBInteraction000379055 |
| | | WBInteraction000402669 |
| | | WBInteraction000424370 |
| | | WBInteraction000424371 |
| | | WBInteraction000424372 |
| | | WBInteraction000470531 |
| | | WBInteraction000473068 |
| | | WBInteraction000501670 |
| | | WBInteraction000501997 |
| | | WBInteraction000502668 |
| | | WBInteraction000503969 |
| | | WBInteraction000504643 |
| | | WBInteraction000518890 |
| | | WBInteraction000519054 |
| | | WBInteraction000519055 |
| | | WBInteraction000519074 |
| | | WBInteraction000519082 |
| | | WBInteraction000519085 |
| | | WBInteraction000519160 |
| | | WBInteraction000519165 |
| | | WBInteraction000519174 |
| | | WBInteraction000522444 |
| | | WBInteraction000524196 |
| | | WBInteraction000541204 |
| | | WBInteraction000541268 |
| | | WBInteraction000541384 |
| | | WBInteraction000541395 |
| | | WBInteraction000542726 |
| | | WBInteraction000555222 |
| | | WBInteraction000555224 |
| | | WBInteraction000555776 |
| | | WBInteraction000556214 |
| | | WBInteraction000556386 |
| | | WBInteraction000556396 |
| | | WBInteraction000556406 |
| | | WBInteraction000576797 |
| | WBProcess | WBbiopr:00000131 |
| Map_info | Map | II | Position | 0.15618 | Error | 0.005052 |
| | Well_ordered |
| | Positive | Inside_rearr | arDp2 |
| | | | mDf18 |
| | | Positive_clone | C15F1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | JK#L22 |
| | | | YK922 |
| | Mapping_data | Multi_point | 51 |
| | | | 709 |
| | | | 843 |
| | | | 1388 |
| | | | 1471 |
| | | | 1473 |
| | | | 2311 |
| | | Pos_neg_data (26) |
| Reference (380) |
| Picture | WBPicture0000013095 |
| Method | Gene |
