| WBGene00006769 | SMap | S_parent | Sequence | Y37E11C |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-33 | Person_evidence | WBPerson261 |
| | | Sequence_name | Y37E11C.1 |
| | | Molecular_name | Y37E11C.1a |
| | | | Y37E11C.1a.1 |
| | | | CE21557 |
| | | | Y37E11C.1b |
| | | | CE31638 |
| | | | Y37E11C.1c |
| | | | CE31639 |
| | | | Y37E11C.1b.1 |
| | | | Y37E11C.1c.1 |
| | | Other_name | CELE_Y37E11C.1 | Accession_evidence | NDB | BX284604 |
| | | Public_name | unc-33 |
| | DB_info | Database | WormQTL | gene | WBGene00006769 |
| | | | WormFlux | gene | WBGene00006769 |
| | | | NDB | locus_tag | CELE_Y37E11C.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006769|UniProtKB=Q01630 |
| | | | | family | PTHR11647 |
| | | | NCBI | gene | 177112 |
| | | | RefSeq | protein | NM_001380147.1 |
| | | | | | NM_001380148.1 |
| | | | | | NM_001038349.4 |
| | | | SwissProt | UniProtAcc | Q01630 |
| | | | TrEMBL | UniProtAcc | U4PLJ8 |
| | | | UniProt_GCRP | UniProtAcc | Q01630 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143034 |
| | Allele (224) |
| | Possibly_affected_by | WBVar02156987 |
| | Legacy_information | e204 : very slow almost paralysed tends to curl dumpyish; weak FITC uptake; amphid phasmid PDE axons abnormal; abnormal neuronal microtubules. ES3 ME0. NA5 (e572 e735). |
| | | See also e572, e1193, e1261, e1358 |
| | | [C.elegansII] e204 : very slow, almost paralysed; tends to curl; dumpyish; weak FITC uptake; amphid, phasmid, PDE, PVP axons abnormal; multiple defects in axonogenesis; abnormally abundant neuronal microtubules. ES3 ME0. OA>10: e572, e735, e1358, m7,mn260::Tc4, rh1030::Tc4, etc. Cloned: 2.8, 3.3, 3.8 kb transcripts (different 5' ends) encoding predicted 523 aa, 679 aa, 854 aa proteins with similarity to collapsin??? Antibody stains all neuron processes in larvae and adults. [Hedgecock et al. 1985; Li et al. 1992; EH; SP] |
| | | [Li W] mn260 is Tc4 insertion in exon VII of longest (3.8kb) unc-33 transcript. rh1030 same insertion site, modified Tc4 element. |
| | Strain | WBStrain00029293 |
| | | WBStrain00023477 |
| | | WBStrain00027172 |
| | | WBStrain00034342 |
| | | WBStrain00034361 |
| | | WBStrain00004266 |
| | | WBStrain00004282 |
| | | WBStrain00004126 |
| | | WBStrain00004183 |
| | | WBStrain00004805 |
| | | WBStrain00006231 |
| | | WBStrain00006153 |
| | | WBStrain00047186 |
| | | WBStrain00047179 |
| | | WBStrain00047196 |
| | | WBStrain00047189 |
| | | WBStrain00047174 |
| | | WBStrain00047197 |
| | | WBStrain00047185 |
| | | WBStrain00047184 |
| | | WBStrain00047180 |
| | | WBStrain00047190 |
| | | WBStrain00047187 |
| | | WBStrain00047188 |
| | | WBStrain00047194 |
| | | WBStrain00047175 |
| | | WBStrain00047193 |
| | | WBStrain00022503 |
| | | WBStrain00047198 |
| | RNASeq_FPKM (74) |
| | GO_annotation (28) |
| | Contained_in_operon | CEOP4092 |
| | Ortholog (37) |
| | Paralog | WBGene00000963 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000964 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | unc-33 encodes a conserved member of the CRMP/TOAD/Ulip/DRP family of proteins that includes mammalian CRMP-2 (Collapsin response mediator protein-2), which is essential for axon guidance and axonogenesis; in C. elegans, unc-33 activity is required for several biological processes including outgrowth and guidance of sensory, motor, and interneurons, sex myoblast migration, normal body movement and morphology, egg laying, and defecation; by homology to CRMP-2, UNC-33 is predicted to bind tubulin heterodimers and promote microtubule assembly, thereby regulating the extension and branching of cellular projections during neuronal polarization; UNC-33 is reportedly expressed exclusively in axonal processes from after early embryogenesis through larval and adult stages. | Paper_evidence | WBPaper00001622 |
| | | | | | WBPaper00002665 |
| | | | | | WBPaper00004362 |
| | | | | | WBPaper00010044 |
| | | | | | WBPaper00025204 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 06 Jun 2005 00:00:00 |
| | | Automated_description | Enables filamin binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including axon guidance; establishment or maintenance of cytoskeleton polarity; and regulation of locomotion. Located in neuron projection. Expressed in amphid socket cell; neuroblasts; neurons; pharyngeal cell; and somatic nervous system. Is an ortholog of human DPYSL2 (dihydropyrimidinase like 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | Y37E11C.1a |
| | | Y37E11C.1b |
| | | Y37E11C.1c |
| | Corresponding_CDS_history | Y37E11C.1:wp82 |
| | | Y37E11C.1a:wp145 |
| | | Y37E11C.1b:wp145 |
| | | Y37E11C.1c:wp145 |
| | | Y37E11C.1c:wp273 |
| | Corresponding_transcript | Y37E11C.1a.1 |
| | | Y37E11C.1b.1 |
| | | Y37E11C.1c.1 |
| | Other_sequence (38) |
| | Associated_feature (12) |
| Experimental_info | RNAi_result | WBRNAi00103588 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00020239 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086120 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00055925 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00055924 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089774 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090316 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00030274 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090157 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089998 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00001590 |
| | | WBCnstr00001591 |
| | | WBCnstr00006869 |
| | Construct_product (15) |
| | Antibody | WBAntibody00000953 |
| | | WBAntibody00000954 |
| | | WBAntibody00001546 |
| | | WBAntibody00001788 |
| | | WBAntibody00001922 |
| | | WBAntibody00002299 |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00024375:Up_vhl-1_vs_hif-1_vhl-1 |
| | | WBPaper00029359_1166 |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1311 |
| | | WBPaper00029359_1320 |
| | | WBPaper00029359_1326 |
| | | WBPaper00029359_1345 |
| | | WBPaper00029359_1439 |
| | | WBPaper00029359_1458 |
| | | WBPaper00029359_1546 |
| | | WBPaper00029359_1549 |
| | | WBPaper00029359_1557 |
| | | WBPaper00029359_1599 |
| | | WBPaper00029359_1618 |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00041072:UTX-1_interacting_protein |
| | | WBPaper00044316:CH3HgCl_7.5uM_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053599:mitosis_vs_meiosis_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060871:M.humicola-extract_4h_regulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADF_AWB |
| | | WBPaper00061340:ADL_parent |
| | | WBPaper00061340:AMso_parent |
| | | WBPaper00061340:ASG_AWA |
| | | WBPaper00061340:ASI_parent |
| | | WBPaper00061340:ASK_parent |
| | | WBPaper00061340:AVH_parent |
| | | WBPaper00061340:M4_parent |
| | | WBPaper00061340:Neuroblast_ADF_AWB |
| | | WBPaper00061340:Neuroblast_AFD_RMD |
| | | WBPaper00061340:Neuroblast_AIZ_FLP |
| | | WBPaper00061340:Neuroblast_ASG_AWA |
| | | WBPaper00061340:Neuroblast_AWC_SAAVx |
| | | WBPaper00061340:Neuroblast_URX_CEPDx |
| | | WBPaper00061340:Parent_of_AMsh_URB |
| | | WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3 |
| | | WBPaper00061340:Parent_of_exc_gland_AVK |
| | | WBPaper00061340:Parent_of_hyp3_ILsoDx |
| | | WBPaper00061340:PLM |
| | | WBPaper00061340:RIA_parent |
| | | WBPaper00061340:RIM_parent |
| | | WBPaper00061527:176662_at-Y53F4B.16 |
| | | WBPaper00061527:pro-3_11683-C44E4.1_9745 |
| | | WBPaper00061651:I4_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_AFD |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064735:bet-1(RNAi)_vs_N2_downregulated |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_downregulated |
| | | WBPaper00064735:mys-1(RNAi)_vs_N2_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065841:28_0 |
| | | WBPaper00066085:sin-3(syb2172)_upregulated |
| | | cgc4489_group_2 |
| | | WBPaper00030985:Photorhabdus_luminescens_downregulated |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | Interaction (69) |
| | WBProcess | WBbiopr:00000010 |
| Map_info | Map | IV | Position | -3.30458 | Error | 0.013709 |
| | Well_ordered |
| | Positive | Inside_rearr | mDp4 |
| | | Positive_clone | EH#143 |
| | | | Y37E11 |
| | | | Y37E11C | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 99 |
| | | | 484 |
| | | | 824 |
| | | | 1643 |
| | | | 3276 |
| | | Multi_point (15) |
| | | Pos_neg_data | 9110 |
| Reference (123) |
| Remark | extracted from Li et al. (1992) |
| | sequence match was given and M57.b and.c but theses overlap with Y37E11C.c which has not been annotated yet. sdm 11/00. will probably acquire name Y37E11C.1 |
| Method | Gene |
