WormBase Tree Display for Gene: WBGene00000035

WBGene00000035 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: ace-1 Person_evidence: WBPerson1417
            WBPerson36909
            WBPerson7188
      Sequence_name: W09B12.1
      Molecular_name (3)
      Other_name: ACE1 Accession_evidence: EMBL X75331
        cest-23
        CELE_W09B12.1 Accession_evidence: NDB BX284606
      Public_name: ace-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 20 May 2019 14:10:26 WBPerson1983 Name_change: CGC_name: ace-1
                Other_name: cest-23
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ace
    Reference_allele: WBVar00095133
    Allele (103)
    Legacy_information: p1000 : class A acetylcholinesterase reduced 100%; no behavioral phenotype alone (ES1 ME3) but ace-2;ace-1 is uncoordinated (hypercontracted) and ace-2;ace-3;ace-1 is L1 lethal. NA7.
      See also e1572
      [C.elegansII] p1000 : class A acetylcholinesterase reduced 100%; no behavioral phenotype alone (ES1 ME3) but ace-2;ace-1 is uncoordinated (hypercontracted) and ace-2;ace-3;ace-1 is L1 lethal. Mosaic focus in muscle. OA6: e1572 etc.Cloned: sequence predicts 609 aa, 37% identity with Torpedo acetylcholinesterase. p1000 is W99op. [Herman and Kari 1985; Arpagaus et al. 1994; FF]
    Strain: WBStrain00024338
      WBStrain00030800
      WBStrain00035826
      WBStrain00040622
      WBStrain00007852
    RNASeq_FPKM (74)
    GO_annotation (31)
    Ortholog (38)
    Paralog (38)
    Structured_description: Concise_description: ace-1 encodes a class A acetylcholinesterase that functions redundantly with ACE-2 with respect to total class A acetylcholinesterase activity, and that genetically interacts with ace-2 and ace-3; ace-1 is expressed in the body wall muscle, sphincter muscle, head neurons, a few pharyngeal muscle cells, and the diagonal and spicule muscles of the male. Paper_evidence: WBPaper00000514
            WBPaper00000795
            WBPaper00002110
            WBPaper00003620
            WBPaper00004251
            WBPaper00004932
          Curator_confirmed: WBPerson48
            WBPerson480
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables acetylcholinesterase activity and identical protein binding activity. Involved in acetylcholine catabolic process and regulation of locomotion. Located in extracellular space. Expressed in CEP; M cell; OLL; body wall musculature; and non-striated muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); and autoimmune disease (multiple). Is an ortholog of human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (19)
  Molecular_info: Corresponding_CDS: W09B12.1
    Corresponding_transcript: W09B12.1.1
    Other_sequence (25)
    Associated_feature: WBsf648845
      WBsf663688
      WBsf979005
      WBsf1008508
      WBsf1008509
      WBsf1008510
      WBsf236851
  Experimental_info: RNAi_result: WBRNAi00075453 Inferred_automatically: RNAi_primary
      WBRNAi00089181 Inferred_automatically: RNAi_primary
      WBRNAi00019735 Inferred_automatically: RNAi_primary
      WBRNAi00030254 Inferred_automatically: RNAi_primary
      WBRNAi00055010 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1222
      Expr1015117
      Expr1030015
      Expr1158543
      Expr2009142
      Expr2027379
    Drives_construct: WBCnstr00008263
      WBCnstr00008264
      WBCnstr00008265
      WBCnstr00008267
      WBCnstr00008268
      WBCnstr00010160
      WBCnstr00018564
      WBCnstr00037779
    Construct_product: WBCnstr00008263
      WBCnstr00008264
      WBCnstr00008265
      WBCnstr00008266
      WBCnstr00008268
      WBCnstr00010160
      WBCnstr00037779
    Regulate_expr_cluster: WBPaper00044452:ace_1_ace-2_downregulated
      WBPaper00044452:ace_1_ace-2_upregulated
    Microarray_results (24)
    Expression_cluster: WBPaper00030922:glycosylated_protein
      WBPaper00032976:dosage_compensated_genes
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:bodywall-muscle_CoreEnriched
      WBPaper00037950:bodywall-muscle_embryo_enriched
      WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00044037:eat-2_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00046121:mesoderm_unique
      WBPaper00048923:Aging_regulated
      WBPaper00048988:daf-2(e1370)_daf-16(mu86)_downregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050163:let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:GABAergic-neuron_enriched
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057140:pptr-1(tm3103)_upregulated
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061340:hmc
      WBPaper00061340:hmc_and_homolog
      WBPaper00061340:hmc_homolog
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:sol-1-jnk-1_18695
      WBPaper00061527:T16H12.9-kin-9_20752
      WBPaper00061651:hmc_enriched
      WBPaper00062095:unc-4(e120)_upregulated_VA-neuron
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065841:1_2
      WBPaper00065841:7_0
      WBPaper00065841:36_0
      WBPaper00065841:36_3
      WBPaper00065841:83_0
      WBPaper00065841:100_0
      WBPaper00065841:102_0
      WBPaper00065841:110_0
      WBPaper00065841:110_1
      WBPaper00065841:143_0
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      cgc4489_group_14
      WBPaper00025032:cluster_182
      WBPaper00027111:rrf-3(pk1426)_downregulated
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035560:ahr-1_upregulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036286:Pattern_I
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
    Interaction (48)
    Anatomy_function: WBbtf0036
      WBbtf0037
      WBbtf0038
      WBbtf1031
      WBbtf1032
      WBbtf1033
  Map_info: Map: X Position: 23.9071 Error: 0.00351
    Well_ordered
    Positive: Positive_clone: W09B12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 3682
      Multi_point: 195
        196
        4958
      Pos_neg_data (15)
    Landmark_gene
  Reference (92)
  Method: Gene