| WBGene00023498 | SMap | S_parent | Sequence | ZK678 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | lin-15A | Person_evidence | WBPerson261 |
| | | Sequence_name | ZK678.1 |
| | | Molecular_name | ZK678.1 |
| | | | ZK678.1.1 |
| | | | CE15383 |
| | | Other_name | lin-15 | CGC_data_submission |
| | | | CELE_ZK678.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | lin-15A |
| | DB_info | Database | AceView | gene | XQ353 |
| | | | WormQTL | gene | WBGene00023498 |
| | | | SignaLink | protein | WBGene00023498 |
| | | | WormFlux | gene | WBGene00023498 |
| | | | NDB | locus_tag | CELE_ZK678.1 |
| | | | NCBI | gene | 181663 |
| | | | RefSeq | protein | NM_078187.8 |
| | | | SwissProt | UniProtAcc | Q27365 |
| | | | TREEFAM | TREEFAM_ID | TF336904 |
| | | | UniProt_GCRP | UniProtAcc | Q27365 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 24 Aug 2004 16:05:45 | WBPerson1971 | Event | Split_from | WBGene00003004 |
| | | Split_from | WBGene00003004 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Reference_allele | WBVar00089409 |
| | Allele (85) |
| | Legacy_information | n309 : adult hermaphrodite Muv vulva either normal or nonfunctional two to six ventral protrusions. Some animals rupture during L4 molt. Adult males have one to three ventral protrusions rudimentary ectopic hook. ME0. Possibly enhanced phenotype in n309/Df. NA12 (n765ts (wildtype at 15x, Muv at 25x, maternal effect Muv at 20x); n767 (weaker allele wildtype alone Muv in homozygotes with lin-9 lin-35 lin-36 or lin- 37); n744 (weaker allele wildtype alone Muv with lin-8 or lin-38); etc.). |
| | | See also e1763, n309, n377, n433, n749, n765, n767, n1139, n1296, n1331 |
| | | [C.elegansII] n309 : adult hermaphrodite Muv, vulva either normal or nonfunctional, two to six ventral protrusions. Some animals rupture during L4 molt. Adult males have one to three ventral protrusions, rudimentary ectopic hook. ME0. Possibly enhanced phenotype in n309/Df. OA>10: e1763, n765ts (wildtype at 15C, Muv at 25C, maternal effect Muv at 20C); n767 (class A allele, wildtype alone, Muv in homozygotes with lin-9,35,36,37), n744 (class B allele, wildtype alone, Muv with lin-8,38), etc. Cloned: locus encodes two collinear transcripts,B (5') and A (3', SL2 transpliced); encode predicted 1440 aa and 719 aa novel proteins. [Clark et al.1994; Huang et al. 1994; MT; PS] |
| | Strain (185) |
| | RNASeq_FPKM (74) |
| | GO_annotation (18) |
| | Contained_in_operon | CEOPX140 |
| | Ortholog (18) |
| | Structured_description | Concise_description | lin-15A encodes a novel protein that contains a THAP zinc-finger-like (C2CH) motif; LIN-15A activity is required non-cell autonomously to negatively regulate vulval development; genetic analysis indicates that lin-15A, a class A synMuv gene, functions upstream of the LIN-3 EGF and the LET-23 EGFR and redundantly with class B synMuv genes such as lin-15B and lin-35 Rb and class C synMuv genes such as trr-1 and mys-1 to regulate vulval development; genetic mosaic analysis suggests that, in regulating vulval development, LIN-15A functions outside of the six vulval precursor cells P(3-8).p, likely acting instead in the surrounding hypodermal tissue; LIN-15A is a broadly expressed nuclear protein whose normal expression depends upon LIN-56, an additional THAP motif-containing protein, with which LIN-15A physically interacts. | Paper_evidence | WBPaper00001360 |
| | | | | | WBPaper00001949 |
| | | | | | WBPaper00001990 |
| | | | | | WBPaper00013412 |
| | | | | | WBPaper00037906 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 04 Mar 2011 00:00:00 |
| | | Automated_description | Involved in several processes, including negative regulation of vulval development; protein stabilization; and vulval development. Located in nucleus. Expressed in gonad. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed (2) |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | ZK678.1 |
| | Corresponding_transcript | ZK678.1.1 |
| | Other_sequence | BE239237.1 |
| | | OVC06601_1 |
| | Associated_feature | WBsf236809 |
| | | WBsf236810 |
| Experimental_info | RNAi_result (47) |
| | Expr_pattern | Expr13101 |
| | | Expr1026271 |
| | | Expr1040141 |
| | | Expr1163064 |
| | | Expr2013161 |
| | | Expr2031393 |
| | Drives_construct | WBCnstr00023854 |
| | Construct_product | WBCnstr00016646 |
| | | WBCnstr00019445 |
| | | WBCnstr00019587 |
| | | WBCnstr00019645 |
| | | WBCnstr00020631 |
| | | WBCnstr00023854 |
| | Antibody | WBAntibody00002219 |
| | | WBAntibody00002253 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00040560:hpl-2_L3_upregulated |
| | | WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050094:glp-1(gf)_upregulated |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051305:vit-2(ac3)_upregulated |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:clk-1(qm30)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060224:atf-6(ok551)_downregulated |
| | | WBPaper00060526:plp-1(ok2155)_upregulated |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060871:M.humicola-extract_1h_regulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061340:RMED |
| | | WBPaper00061478:pie-1(ne4433)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:nrde-3-tra-4_10484 |
| | | WBPaper00061651:ADF_enriched |
| | | WBPaper00061651:AIN_enriched |
| | | WBPaper00061651:AIY_enriched |
| | | WBPaper00061651:CAN_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:I1_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VA_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00062056:lin-15B(n744)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066085:hda-3(ok1991)_upregulated |
| | | WBPaper00066085:sin-3(syb2172)_upregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_9 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00024671:AFD_vs_AWB_upregulated |
| | | WBPaper00025032:cluster_162 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00028483:Up_mes-4_vs_WT |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041370:spg-7(RNAi)_upregulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:daf-16(mgDF50)_regulated_Starved |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(143_min) |
| | | [cgc5767]:expression_class_E_pi(66_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction (321) |
| Map_info | Map | X | Position | 22.9459 | Error | 0.001185 |
| | Well_ordered |
| | Positive | Positive_clone | PS#74B3 |
| | | | ZK678 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 4458 |
| | | | 4457 |
| | | | 6060 |
| | | | 7015 |
| | | | 7082 |
| | | Multi_point | 5356 |
| | | Pos_neg_data | 4461 |
| | | | 491 |
| | | | 518 |
| | | | 519 |
| | | | 536 |
| | Landmark_gene |
| Reference (300) |
| Remark | To properly reflect that this locus encodes two distinct products, this gene was created from the former lin-15 gene on the advice of the CGC. [krb 040824] |
| Method | Gene |
