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WormBase Tree Display for Gene: WBGene00000047

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Name Class

WBGene00000047SMapS_parentSequenceZC504
IdentityVersion1
NameCGC_nameacr-8Person_evidenceWBPerson1430
Sequence_nameZC504.2
Molecular_nameZC504.2
ZC504.2.1
CE53615
ZC504.2.2
Other_nameCELE_ZC504.2Accession_evidenceNDBBX284606
Public_nameacr-8
DB_infoDatabaseAceViewgeneXL33
WormQTLgeneWBGene00000047
WormFluxgeneWBGene00000047
NDBlocus_tagCELE_ZC504.2
PanthergeneCAEEL|WormBase=WBGene00000047|UniProtKB=Q23355
familyPTHR18945
NCBIgene181246
RefSeqproteinNM_001375112.3
TrEMBLUniProtAccQ23355
UniProt_GCRPUniProtAccQ23355
OMIMgene100690
100710
100720
100725
100730
118503
118505
118507
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:19WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classacr
Allele (53)
StrainWBStrain00031896
RNASeq_FPKM (74)
GO_annotation (27)
Ortholog (77)
Paralog (100)
Structured_descriptionConcise_descriptionacr-8 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR); ACR-8 falls into the 'ACR-8' class of nAChR subunits, which includes ACR-12 and ACR-13.Paper_evidenceWBPaper00005223
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in body wall musculature; enteric muscle; nerve ring; neurons; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (30)
Molecular_infoCorresponding_CDSZC504.2
Corresponding_CDS_historyZC504.2:wp54
ZC504.2:wp124
ZC504.2:wp272
Corresponding_transcriptZC504.2.1
ZC504.2.2
Other_sequence (16)
Associated_featureWBsf718691
WBsf1006700
Experimental_infoRNAi_resultWBRNAi00058977Inferred_automaticallyRNAi_primary
Expr_patternExpr3704
Expr4340
Expr4979
Expr1012528
Expr1030022
Expr1162412
Expr2009197
Expr2027435
Drives_construct (11)
Construct_productWBCnstr00006479
WBCnstr00006480
WBCnstr00011615
WBCnstr00037770
Microarray_results (19)
Expression_clusterWBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032976:dosage_compensated_genes
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:bodywall-muscle_larva_enriched
WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00048952:glucose_induced
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055941:nuo-6(qm200)_downregulated
WBPaper00056167:Cry5B_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058678:DAF-12_downregulated_PVD
WBPaper00058725:sftb-1(cer39)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:AIA
WBPaper00061340:AVB
WBPaper00061340:OLL
WBPaper00061340:RIB
WBPaper00061527:sol-1-jnk-1_18695
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062156:jmjd-5(zr1234)_upregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062345:bortezomib_4h_downregulated_N2
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mes-4(bn73)_upregulated_PGCs
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00064769:him-17(me24)_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065258:anchor-cell_depleted
WBPaper00065560:E.coli-HB101_downregulated_F3
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
WBPaper00065841:1_1
WBPaper00065841:48_0
WBPaper00065841:86_0
WBPaper00065841:100_0
WBPaper00065841:142_0
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031003:0hr_muscle_enriched
WBPaper00031003:24hr_muscle_enriched
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00035084:embryo_enriched_AIN-2_IP
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035588:alg-1(-)_upregulated
WBPaper00036130:mir-243_up_regulated
WBPaper00036286:Pattern_G
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040876:mir-35_downregulated
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00040985:AIN-2_asynchronous_muscle
WBPaper00042548:miRISC_enriched
WBPaper00045673:colistin_upregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00053236:daf-16(mgDF50)_regulated_Starved
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
InteractionWBInteraction000133959
WBInteraction000136793
WBInteraction000142026
WBInteraction000144320
WBInteraction000209431
WBInteraction000504009
WBInteraction000518504
WBInteraction000543443
Map_infoMapXPosition2.18612Error0.001806
PositivePositive_cloneZC504Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4886
4909
Pseudo_map_position
ReferenceWBPaper00003425
WBPaper00005223
WBPaper00006324
WBPaper00011839
WBPaper00018912
WBPaper00024530
WBPaper00024783
WBPaper00025218
WBPaper00025762
WBPaper00026249
WBPaper00027611
WBPaper00028231
WBPaper00028761
WBPaper00029012
WBPaper00030363
WBPaper00031105
WBPaper00033737
WBPaper00034730
WBPaper00035364
WBPaper00035548
WBPaper00041227
WBPaper00041959
WBPaper00054426
WBPaper00055090
WBPaper00058964
WBPaper00060283
WBPaper00061589
WBPaper00065144
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene