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WormBase Tree Display for Gene: WBGene00000063

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Name Class

WBGene00000063SMapS_parentSequenceT04C12
IdentityVersion1
NameCGC_nameact-1Person_evidenceWBPerson259
Sequence_nameT04C12.6
Molecular_nameT04C12.6
T04C12.6.1
CE13148
Other_nameCELE_T04C12.6Accession_evidenceNDBBX284605
Public_nameact-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:19WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classact
Allele (13)
StrainWBStrain00033488
In_clusteract-123
RNASeq_FPKM (74)
GO_annotation (17)
Ortholog (46)
Paralog (11)
Structured_descriptionConcise_descriptionact-1 encodes an actin isoform that is required for proper body wall muscle and pharyngeal muscle structures and the motility of animals; actins have highly similar amino acid sequences; ACT-1 is identical to ACT-3; act-1 functions redundantly with two other actin isoforms, act-2 and act-3, to control cytoplasmic microfilament function in the early embryo.Paper_evidenceWBPaper00001178
WBPaper00014413
WBPaper00027028
Curator_confirmedWBPerson324
Date_last_updated29 Mar 2007 00:00:00
Automated_descriptionPredicted to be a structural constituent of cytoskeleton. Involved in cortical actin cytoskeleton organization; embryo development; and mitotic cytokinesis. Located in striated muscle thin filament. Expressed in body wall musculature and gonad. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Is an ortholog of human ACTB (actin beta).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:1588Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:132)
DOID:0081113Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:144)
DOID:10881Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:132)
DOID:0081112Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:132)
DOID:0110550Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:144)
Molecular_infoCorresponding_CDST04C12.6
Corresponding_transcriptT04C12.6.1
Other_sequence (456)
Associated_featureWBsf647226
WBsf647227
WBsf661678
WBsf661679
WBsf1001264
WBsf1001265
WBsf1020400
WBsf232452
WBsf232453
WBsf232454
Experimental_infoRNAi_result (55)
Expr_patternExpr558
Expr2793
Expr4555
Expr9252
Expr1030024
Expr1156000
Expr2009221
Expr2027458
Drives_construct (4)
Construct_productWBCnstr00015675
WBCnstr00015678
WBCnstr00037760
WBCnstr00038658
AntibodyWBAntibody00001783
Microarray_resultsSMD_T04C12.6
GPL19516_CGZ0033111
GPL19516_CGZ0033112
GPL19516_CGZ0033113
GPL19516_CGZ0033114
GPL21109_T04C12.6.1
GPL8304_CE_WBGene00000063_B
GPL9450_T04C12.6
cea2.c.38095
Expression_clusterWBPaper00005943:L3_specific
WBPaper00024704:Soluble_protein
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00037047:insoluble_protein
WBPaper00037946:LIN-39_interacting
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038289:oocyte_protein
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040221:DAF-12_target_ALF4
WBPaper00040731:Static_Magnetic_Field_upregulated
WBPaper00040965:lipid-droplet_associated_protein
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_upregulated_L1
WBPaper00045316:prg-1_upregulated_L2
WBPaper00045316:prg-1_upregulated_L3
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00046217:clk-1(qm30)_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00048910:mRNA-interacting_protein
WBPaper00048923:Aging_regulated
WBPaper00048971:daf-16(mgDf50)_downregulated_L1
WBPaper00048988:daf-2(e1370)_daf-16(mu86)_upregulated_neuron
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049595:P.aeruginosa_24h_downregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049942:HeatShock_upregulated_hsf-1(+)
WBPaper00050053:muscle_enriched_Day4
WBPaper00050182:lmn-1(L535P)_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050698:DEP-1_interacting
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050801:DPY-21_dauer_regulome
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00051558:aging_regulated
WBPaper00052881:B.subtilis-biofilm_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053289:DREAM-target
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053318:Aging_downregulated_mRNA_N2
WBPaper00053318:mir-71(n4115)_downregulated_mRNA
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053664:ins-11(tm1053)_upregulated
WBPaper00054996:membranous_oraganelle_CE
WBPaper00054996:unactivated_spermatid_CE
WBPaper00055049:S.gordonii_upregulated
WBPaper00055103:thoc-5(wy822)_downregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055897:heat-shock_upregulated
WBPaper00055971:nhl-2(ok818)_20C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056161:male_enriched_siRNA
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056474:ivermectin-resistent_vs_N2_upregulated_protein
WBPaper00056673:Gamma-Irradiation_regulated
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056900:ERH-2_interacting
WBPaper00056900:PID-3_interacting
WBPaper00056900:TOFU-6_interacting
WBPaper00056900:TOST-1_interacting
WBPaper00058691:CFP-1_interacting_protein
WBPaper00059471:EGL-43_interacting
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059605:MUT-16_interacting
WBPaper00059739:hira-1(gk835598)_downregulated_L4
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00060084:cco-1(RNAi)_downregulated_N2
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061285:wounding_0h_downregulated
WBPaper00061340:BWM_far_posterior
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:mu_sph
WBPaper00061340:Neuroblast_AVG_RIR
WBPaper00061340:Parent_of_K_Kprime
WBPaper00061341:28C_24h_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061527:tars-1-AFFX-r2-3026-5_at
WBPaper00061651:Rectal_gland_enriched
WBPaper00061651:Spermatheca_enriched
WBPaper00062002:Day4-adult_secretome
WBPaper00062002:L3_secretome
WBPaper00062143:PQN-59_interacting
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:etr-1(lq61)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_downregulated_protein
WBPaper00064201:SNA-3_interacting
WBPaper00064257:UNG-1_interacting
WBPaper00064315:mes-4(bn73)_downregulated_PGCs
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064933:E.coli-binding_secret_protein
WBPaper00064992:Eugenol_downregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065149:lin-52(n771)_downregulated
WBPaper00065158:AFD_depleted
WBPaper00065623:16
WBPaper00065623:79
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:7_0
WBPaper00065841:7_3
cgc4489_group_3
WBPaper00005124:estrogen_10-5M_regulated
WBPaper00005124:progesterone_10-7M_regulated
WBPaper00013462:daf-2_age_regulated
WBPaper00032165:A_to_C_transit_increased
WBPaper00036286:Pattern_G
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_aging
WBPaper00040858:eQTL_regulated_reproductive
[cgc6390]:Cluster_C
Interaction (326)
WBProcessWBbiopr:00000096
Map_infoMapVPosition2.94475Error0.000513
PositivePositive_cloneT04C12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (106)
RemarkT04C12.4 changed to T04C12.6. email from JAH 0109
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene