| WBGene00000195 | SMap | S_parent | Sequence | F53H8 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | arr-1 |
| | | Sequence_name | F53H8.2 |
| | | Molecular_name | F53H8.2 |
| | | | F53H8.2.1 |
| | | | CE28831 |
| | | Other_name | CELE_F53H8.2 | Accession_evidence | NDB | BX284606 |
| | | Public_name | arr-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | arr |
| | Allele (60) |
| | Strain | WBStrain00031400 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00047486 |
| | | 00047487 |
| | | 00047488 |
| | | 00047489 |
| | | 00047490 |
| | | 00047491 |
| | | 00047492 |
| | | 00047493 |
| | | 00106977 |
| | Ortholog (47) |
| | Structured_description | Concise_description | arr-1 encodes the C. elegans beta-arrestin ortholog (OMIM:107940, 107941, mice lacking beta-arrestin family members display defects in G protein-coupled receptor desensitization); by homology, ARR-1 is predicted to be a multifunctional adaptor protein that interacts with intracellular signaling molecules as well as activated and phosphorylated G protein-coupled and TGF-beta receptors to: 1) downregulate receptor signaling, 2) promote receptor endocytosis, and 3) activate MAP kinase- and Src-dependent signaling pathways; in vivo, arr-1 activity is required for normal egg laying and for proper olfactory adaptation and recovery to volatile odorants; in addition, animals doubly mutant for arr-1 and grk-2, which encodes a G protein-coupled receptor kinase, are sick and slow growing; ARR-1 is detected throughout the nervous system and is highly expressed in the amphid chemosensory neurons; in neuronal cells, ARR-1 appears to be largely cytoplasmic; ARR-1 interacts physically with clathrin and beta2-adaptin, two proteins involved in receptor endocytosis. | Paper_evidence | WBPaper00005520 |
| | | | | | WBPaper00013467 |
| | | | | | WBPaper00025173 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 25 Jun 2007 00:00:00 |
| | | Automated_description | Predicted to enable G protein-coupled receptor binding activity. Involved in positive regulation of growth rate. Predicted to be located in cytoplasm. Expressed in HSN; amphid neurons; somatic nervous system; and tail. Human ortholog(s) of this gene implicated in eye disease (multiple); major depressive disorder; and portal hypertension. Is an ortholog of human ARRB1 (arrestin beta 1) and ARRB2 (arrestin beta 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (12) |
| Molecular_info | Corresponding_CDS | F53H8.2 |
| | Corresponding_transcript | F53H8.2.1 |
| | Other_sequence (23) |
| | Associated_feature | WBsf647807 |
| | | WBsf662449 |
| | | WBsf662450 |
| | | WBsf1003900 |
| | | WBsf1003901 |
| | | WBsf1003902 |
| | | WBsf1003903 |
| | | WBsf235298 |
| Experimental_info | RNAi_result (14) |
| | Expr_pattern | Expr4299 |
| | | Expr6162 |
| | | Expr6163 |
| | | Expr8610 |
| | | Expr8611 |
| | | Expr1015865 |
| | | Expr1030114 |
| | | Expr1152011 |
| | | Expr2009408 |
| | | Expr2027644 |
| | Drives_construct | WBCnstr00002995 |
| | | WBCnstr00004493 |
| | | WBCnstr00011896 |
| | | WBCnstr00013399 |
| | | WBCnstr00037671 |
| | | WBCnstr00038325 |
| | Construct_product | WBCnstr00013399 |
| | | WBCnstr00037671 |
| | | WBCnstr00038320 |
| | | WBCnstr00038321 |
| | | WBCnstr00038322 |
| | | WBCnstr00038323 |
| | | WBCnstr00038324 |
| | | WBCnstr00038325 |
| | Antibody | WBAntibody00001658 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00032031:DConiospora_downregulated_OligoArray_24h |
| | | WBPaper00032976:non_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040990:PA14_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056039:efa-6(tm3124)_upregulated |
| | | WBPaper00056039:ptl-1(ok621)_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:ADA_ADE_grandparent |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:I5 |
| | | WBPaper00061340:Neuroblast_ALM_BDU |
| | | WBPaper00061340:RIB |
| | | WBPaper00061466:nath-10(icb102)_downregulated |
| | | WBPaper00061527:cfz-2_18944-cfz-2_2268 |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:URB_enriched |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062456:doxycycline_upregulated_N2_protein |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_upregulated_protein |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | cgc4489_group_23 |
| | | WBPaper00025032:cluster_7 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00033101:spr-5_regulated |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00037695:CC_3-day |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00053827:pyoverdine_upregulated |
| | | [cgc5767]:cluster_13 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (52) |
| | Anatomy_function (11) |
| Map_info | Map | X | Position | -18.9097 | Error | 0.005023 |
| | Positive | Positive_clone | F53H8 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4163 |
| | Pseudo_map_position |
| Reference (25) |
| Remark | Sequence connection from [Palmitessa A, Benovic J.], 02/06/12 krb. |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
