| WBGene00000406 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | cdk-4 | Person_evidence | WBPerson346 |
| | | Sequence_name | F18H3.5 |
| | | Molecular_name | F18H3.5 |
| | | | F18H3.5.1 |
| | | | CE18608 |
| | | Other_name | CELE_F18H3.5 | Accession_evidence | NDB | BX284606 |
| | | Public_name | cdk-4 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cdk |
| | Allele (67) |
| | Legacy_information | [Krause MW] cdk-4 is a cyclin dependent kinase related to cdk-4 and cdk-6 from other organims. Homozygous cdk-4(gv3) animals usually arrest in L2 due to no, or limited, proliferation of the post-embryonic blast cells. About 3% of animals make it to a late stage of development. |
| | Strain | WBStrain00023588 |
| | | WBStrain00034600 |
| | | WBStrain00034601 |
| | | WBStrain00003937 |
| | RNASeq_FPKM (74) |
| | GO_annotation (36) |
| | Ortholog (43) |
| | Paralog (17) |
| | Structured_description | Concise_description | cdk-4 encodes two isoforms of a cyclin-dependent serine/threonine protein kinase orthologous to human CDK4 and CDK6 (OMIM:123829 and OMIM:603368, mutated in cutanous malignant melanoma) which complex with D-type cyclins to regulate progression through the G1 phase of the cell cycle; CDK-4 activity is essential for G1 progression in postembryonic blast cells and as a result, cdk-4 mutant animals generally arrest during larval stages; the lethality generated by cdk mutations, also seen in animals doubly mutant for cdk-4 and cyd-1, a C. elegans D-type cyclin, can be suppressed by mutations in lin-35/Rb suggesting that, as in other organisms, LIN-35/Rb may be a major target of CDK-4/CYD-1 kinase activity; CDK-4 expression is first detected in neuronal and hypodermal lineages during mid-to-late embryogenesis, with postembryonic expression detected in hypodermal seam cells, cells of the P lineage which will give rise to ventral cord neurons, and cells of the somatic gonad, the vulva, and the intestine. | Paper_evidence | WBPaper00003752 |
| | | | | | WBPaper00004192 |
| | | | | | WBPaper00005298 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables protein serine/threonine kinase activity. Involved in nematode larval development; positive regulation of cell cycle process; and reproductive process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Expressed in gonad; intestine; neurons; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); central nervous system cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human CDK4 (cyclin dependent kinase 4) and CDK6 (cyclin dependent kinase 6). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00046296 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 04 Feb 2015 00:00:00 |
| | Potential_model (24) |
| Models_disease_in_annotation | WBDOannot00000346 |
| Molecular_info | Corresponding_CDS | F18H3.5 |
| | Corresponding_CDS_history | F18H3.5b:wp61 |
| | | F18H3.5b:wp271 |
| | Corresponding_transcript | F18H3.5.1 |
| | Other_sequence (22) |
| | Associated_feature | WBsf654531 |
| | | WBsf671198 |
| | | WBsf1007631 |
| | | WBsf1024243 |
| | | WBsf238141 |
| Experimental_info | RNAi_result (13) |
| | Expr_pattern | Expr1156 |
| | | Expr1017984 |
| | | Expr1030223 |
| | | Expr1148945 |
| | | Expr2009811 |
| | | Expr2028052 |
| | Drives_construct | WBCnstr00010112 |
| | | WBCnstr00016185 |
| | | WBCnstr00020118 |
| | | WBCnstr00020130 |
| | | WBCnstr00021180 |
| | | WBCnstr00037565 |
| | Construct_product | WBCnstr00010112 |
| | | WBCnstr00016185 |
| | | WBCnstr00020118 |
| | | WBCnstr00020130 |
| | | WBCnstr00037565 |
| | Regulate_expr_cluster | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | Microarray_results (24) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032425:up_in_rde-4 |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00042561:smg-2(RNAi)_downregulated |
| | | WBPaper00044037:eat-2_downregulated |
| | | WBPaper00044037:eat-2_regulated_nhr-62_dependent |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046887:WNT-target |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050903:mir-35-41(nDf50)_25C_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057041:spc-1(cas971)_downregulated |
| | | WBPaper00057158:mdt-15(tm2182)_dependent_15C_upregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059987:Wounding_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060764:swsn-1(os22ts)_downregulated |
| | | WBPaper00060886:spr-5(by101);met-2(n4256)_downregulated |
| | | WBPaper00060886:spr-5(by101)_downregulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:AMso_parent |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:I1_parent |
| | | WBPaper00061340:M1_parent |
| | | WBPaper00061340:Parents_of_PHsh_hyp8_hyp9 |
| | | WBPaper00061340:Parent_of_hyp3_ILsoDx |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:fbxc-28-sdz-28 |
| | | WBPaper00061527:utx-1_2886-swan-1_2192 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_transcript |
| | | WBPaper00062456:doxycycline_downregulated_N2_transcript |
| | | WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:Cisplatin_downregulated_diploid |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | cgc4489_group_5 |
| | | WBPaper00025032:cluster_30 |
| | | WBPaper00025032:cluster_185 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048624:hlh-25(ok1710)_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction (61) |
| Map_info | Map | X | Position | 12.6771 | Error | 0.006799 |
| | Positive | Positive_clone | F18H3 | Person_evidence | WBPerson346 |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | H06A10 | Person_evidence | WBPerson346 |
| | Mapping_data | Multi_point | 4138 |
| | | | 4196 |
| | Pseudo_map_position |
| Reference (36) |
| Remark | The deletion allele was isolated in a PCR-based screen following the method of Barstead and Moulder. The deletion break points have been identified by sequence. We have rescued the cdk-4(gv3) mutant using a wild type copy of the cdk-4 cDNA expressed under the control of cdk-4 ~3 kb of 5' flanking sequences. |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
