WBGene00000447 | SMap | S_parent | Sequence | F55B12 |
| Identity | Version | 1 |
| | Name | CGC_name | ceh-24 | Person_evidence | WBPerson83 |
| | | Sequence_name | F55B12.1 |
| | | Molecular_name | F55B12.1 |
| | | | F55B12.1.1 |
| | | | CE25006 |
| | | Other_name | CELE_F55B12.1 | Accession_evidence | NDB | BX284605 |
| | | Public_name | ceh-24 |
| | DB_info | Database | AceView | gene | 5O295 |
| | | | WormQTL | gene | WBGene00000447 |
| | | | WormFlux | gene | WBGene00000447 |
| | | | NDB | locus_tag | CELE_F55B12.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000447|UniProtKB=Q9NLC2 |
| | | | | family | PTHR24340 |
| | | | NCBI | gene | 179877 |
| | | | RefSeq | protein | NM_074018.5 |
| | | | SwissProt | UniProtAcc | Q9NLC2 |
| | | | UniProt_GCRP | UniProtAcc | Q9NLC2 |
| | | | OMIM | gene | 600635 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ceh |
| | Allele (38) |
| | Legacy_information | [C.elegansII] pk92 : Tc1 insertion, no known phenotype.Encodes NK class homeoprotein. ceh-24:lacZ expressed in pharynx muscle m8, vulval muscles,some head neurons. [PD] |
| | Strain | WBStrain00030582 |
| | | WBStrain00030580 |
| | | WBStrain00030581 |
| | | WBStrain00008317 |
| | | WBStrain00048954 |
| | | WBStrain00051837 |
| | RNASeq_FPKM (74) |
| | GO_annotation (14) |
| | Ortholog (36) |
| | Paralog | WBGene00000428 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000434 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000445 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000450 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000449 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000584 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | ceh-24 encodes an NK class homeodomain protein orthologous to human NK2 Homeobox 1 (NKX2-1; OMIM:600635) which is expressed in the thyroid, lung, and bronchial epithelia and which, when mutated, leads to disease. | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 29 Oct 2009 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; regulation of transcription by RNA polymerase II; and regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Expressed in head muscle; intestine; neurons; non-striated muscle; and ventral nerve cord. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Is an ortholog of human NKX2-1 (NK2 homeobox 1) and NKX2-4 (NK2 homeobox 4). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11825) |
| | | DOID:12859 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11825) |
| Molecular_info | Corresponding_CDS | F55B12.1 |
| | Corresponding_transcript | F55B12.1.1 |
| | Other_sequence | FD515256.1 |
| | | ACC33915_1 |
| | | EY472969.1 |
| | | Oden_isotig14746 |
| | | MIC05372_1 |
| | | Oden_isotig14745 |
| | | MI06369 |
| | | CSC01139_1 |
| | | JI169963.1 |
| | Associated_feature | WBsf647488 |
| | | WBsf662047 |
| | | WBsf919538 |
| | | WBsf919539 |
| | | WBsf978299 |
| | | WBsf1001892 |
| | | WBsf1001893 |
| | | WBsf1001894 |
| | | WBsf1020764 |
| | | WBsf232828 |
| | Transcription_factor | WBTranscriptionFactor000318 |
| Experimental_info | RNAi_result (16) |
| | Expr_pattern (18) |
| | Drives_construct (16) |
| | Construct_product (6) |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00029359_1280 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1604 |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040560:hpl-2_embryo_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:tunicamycin_downregulated |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:NMDA-neuron_enriched |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_acr-2(n2420gf)_regulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060526:plp-1(ok2155)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RME |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061527:rab-28-jbts-14_9542 |
| | | WBPaper00061636:atracurium_downregulated |
| | | WBPaper00061651:RME_DV_enriched |
| | | WBPaper00061651:SIA_enriched |
| | | WBPaper00061651:SIB_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062095:unc-4(e120)_upregulated_VA-neuron |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:7_0 |
| | | WBPaper00065841:7_3 |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:29_0 |
| | | WBPaper00065841:46_0 |
| | | WBPaper00065841:68_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_13 |
| | | cgc4489_group_17 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:rrf-3(pk1426)_downregulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | Interaction (35) |
| | WBProcess | WBbiopr:00000040 |
| Map_info | Map | V | Position | 5.59946 | Error | 0.002711 |
| | Positive | Positive_clone | F55B12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | PD#BH911 |
| | Mapping_data | Multi_point | 4207 |
| | | | 5333 |
| | Pseudo_map_position |
| Reference (32) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |