WBGene00000962 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | T21E12 |
| Identity | Version | 1 |
| | Name | CGC_name | dhc-1 | Person_evidence | WBPerson1562 |
| | | Sequence_name | T21E12.4 |
| | | Molecular_name | T21E12.4a |
| | | | T21E12.4a.1 |
| | | | CE23997 |
| | | | T21E12.4b |
| | | | CE51690 |
| | | | T21E12.4b.1 |
| | | Other_name | let-354 |
| | | | spd-4 |
| | | | CELE_T21E12.4 | Accession_evidence | NDB | BX284601 |
| | | Public_name | dhc-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info (13) |
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00028525 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 24 Aug 2021 00:00:00 |
| | | DOID:0050453 | Homo sapiens | Paper_evidence | WBPaper00028525 |
| | | | | Accession_evidence | OMIM | 607432 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 17 Apr 2013 00:00:00 |
| | Potential_model | DOID:0070043 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2961) |
| | | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2961) |
| | | DOID:0070351 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2961) |
| | | DOID:0110175 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2961) |
| | Disease_relevance | In humans, mutations in the LIS1 gene (Platelet activating factor acetylhydrolase, isoform 1B, alpha subunit; PAFAH1B1) and the LIS1 pathway, are implicated in Lissencephaly, a developmental abnormality associated with a failure of neuronal migration in the cerebral cortex, leading to mental retardation and epilepsy; human NDE1 and NDEL1, are effectors of LIS1; the elegans genetic model for epileptic siezures consists of lis-1 mutants that are responsive to the common seizure inducer pentylenetetrazole (PTZ) and diplay a distinct convulsive phenotype; studies in the worm show that dhc-1/dynein heavy chain (orthologous to human DYNC1H1), is a LIS1 pathway component and worms depleted for LIS1 pathway components via RNA interference, NUD-1, NUD-2, DHC-1, CDK-5, and CDKA-1, also exhibited significant convulsions following PTZ treatment; further nud-1 (orthologous to human NUDC), nud-2/NDE1 and cdk-5 show significant enhancement in convulsions in a lis-1 heterozygous background when compared with the wild-type background; these animals are also less likely to recover when PTZ treatment is removed, when compared to wild-type; these studies show that while knocking down target genes (lis-1, cdk-5, and cdka-1 that function in neuronal migration), and their interacting proteins like nud-1, nud-2 and dhc-1, does not yield spontaneous convulsions in C. elegans, further alterations in the neural environment through the application of PTZ serve to pass a critical threshold within these animals. | Homo sapiens | Curator_confirmed | WBPerson324 |
| Models_disease_in_annotation | WBDOannot00000150 |
| | WBDOannot00001012 |
| Molecular_info | Corresponding_CDS | T21E12.4a |
| | | T21E12.4b |
| | Corresponding_transcript | T21E12.4a.1 |
| | | T21E12.4b.1 |
| | Other_sequence (122) |
| | Associated_feature | WBsf643215 |
| | | WBsf656205 |
| | | WBsf656206 |
| | | WBsf656207 |
| | | WBsf656208 |
| | | WBsf983394 |
| | | WBsf217528 |
| | | WBsf217529 |
| Experimental_info | RNAi_result (43) |
| | Expr_pattern (19) |
| | Drives_construct | WBCnstr00003093 |
| | | WBCnstr00007434 |
| | | WBCnstr00008880 |
| | | WBCnstr00013402 |
| | | WBCnstr00037176 |
| | | WBCnstr00042469 |
| | Construct_product | WBCnstr00007434 |
| | | WBCnstr00008880 |
| | | WBCnstr00013402 |
| | | WBCnstr00037176 |
| | | WBCnstr00039347 |
| | | WBCnstr00042469 |
| | Antibody | WBAntibody00000242 |
| | | WBAntibody00000917 |
| | | WBAntibody00002792 |
| | | WBAntibody00002860 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00028451:Oogenic_protein |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00031132:LiCl_downregulated |
| | | WBPaper00032425:up_in_lin-35 |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00041072:UTX-1_interacting_protein |
| | | WBPaper00044037:eat-2_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044578:4-day_reduced-humidity_upregulated_proteomics |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046303:P.aeruginosa_upregulated_protein |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049159:Microwave_upregulated_L4 |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPS_downregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050225:flp-6(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051265:F1_morc-1(tm6048)_downregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051555:atm-1(gk186)_regulated_protein |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:Excretory_gland |
| | | WBPaper00061340:mc1 |
| | | WBPaper00061340:mc2 |
| | | WBPaper00061340:mc3 |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:tars-1-AFFX-r2-3026-5_at |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064624:iHg-induced_aggregome |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065623:3 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | cgc4489_group_19 |
| | | WBPaper00025032:cluster_21 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_2 |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00041002:HF_3d_0.2mM_Down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | [cgc5767]:cluster_8 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(41_min) |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction (292) |
| | WBProcess | WBbiopr:00000017 |
| Map_info | Map | I | Position | -1.31043 | Error | 0.007943 |
| | Well_ordered |
| | Positive | Positive_clone | T21E12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data (3) |
| Reference (130) |
| Remark | Sequence connection from [Schmidt D, Strome S] |
| | Previous connection of genomic_sequence to dhc-14 was a typo [030225 ck1] |
| Method | Gene |