| WBGene00001865 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | T04A11 |
| Identity | Version | 1 |
| | Name | CGC_name | him-6 | Person_evidence | WBPerson261 |
| | | Sequence_name | T04A11.6 |
| | | Molecular_name | T04A11.6 |
| | | | T04A11.6.1 |
| | | | CE31724 |
| | | Other_name | blm-1 |
| | | | CELE_T04A11.6 | Accession_evidence | NDB | BX284604 |
| | | Public_name | him-6 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info (11) |
| Disease_info | Experimental_model | DOID:2717 | Homo sapiens | Paper_evidence | WBPaper00013454 |
| | | | | Accession_evidence | OMIM | 210900 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 05 Jun 2017 00:00:00 |
| | Potential_model | DOID:2717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1058) |
| | Disease_relevance | Mutations in the human BLM gene (a RecQ family DNA helicase) are implicatd in Bloom syndrome, an inherited disorder characterized by short stature, increased sensitivity to sunlight, a greatly increased risk of cancer and infertility; at the cellular level it is characterized by genomic instability, in particular, hyperrecombination between sister chromatids and homologous chromosomes; the C. elegans BLM ortholog, him-6, exhibits DNA-dependent ATPase activity and mutants show an enhanced irradiation sensitivity, a partially defective S-phase checkpoint, and in reduced levels of DNA-damage induced apoptosis. | Homo sapiens | Paper_evidence | WBPaper00013454 |
| | | | | Accession_evidence | OMIM | 604610 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 05 Jun 2017 00:00:00 |
| Models_disease_asserted | WBDOannot00000132 |
| | WBDOannot00000436 |
| | WBDOannot00000437 |
| | WBDOannot00000438 |
| Molecular_info | Corresponding_CDS | T04A11.6 |
| | Corresponding_CDS_history | T04A11.6:wp84 |
| | Corresponding_transcript | T04A11.6.1 |
| | Other_sequence (32) |
| | Associated_feature | WBsf660814 |
| | | WBsf660815 |
| | | WBsf998136 |
| | | WBsf998137 |
| | | WBsf1018380 |
| | | WBsf1018381 |
| | | WBsf229300 |
| Experimental_info | RNAi_result (4) |
| | Expr_pattern | Expr1024637 |
| | | Expr1031098 |
| | | Expr1155954 |
| | | Expr2012431 |
| | | Expr2030667 |
| | Drives_construct | WBCnstr00036640 |
| | Construct_product | WBCnstr00036640 |
| | Antibody | WBAntibody00002533 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00035211:age-1_vs_age-1_downregulated |
| | | WBPaper00035211:age-1_vs_N2_downregulated |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045050:csr-1(hypomorph)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048611:MnCl2_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_8 |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPS_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00057006:DietaryRestriction_downregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:I5 |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061527:ima-1_20458-bath-41 |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065841:32_0 |
| | | WBPaper00065841:111_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:130_0 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_10 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00029437:dcr-1_downregulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00055435:AuNPs_downregulated |
| | | [cgc5767]:cluster_24 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(122_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MDE |
| | | [cgc5767]:expression_class_MD_pd(23_min) |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_F |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (123) |
| Map_info | Map | IV | Position | 5.98937 | Error | 0.002716 |
| | Well_ordered |
| | Positive | Positive_clone | T04A11 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 111 |
| | | | 112 |
| | | | 113 |
| | | | 5281 |
| | | | 5470 |
| | | Pos_neg_data | 5444 |
| | | | 5445 |
| | | | 5446 |
| | | | 5447 |
| Reference (74) |
| Remark | Sequence connection from [Wicky C, Muller F] |
| Method | Gene |
