WBGene00001965 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | C17C3 |
| Identity | Version | 1 |
| | Name | CGC_name | hlh-26 | Person_evidence | WBPerson346 |
| | | Sequence_name | C17C3.8 |
| | | Molecular_name | C17C3.8 |
| | | | C17C3.8.1 |
| | | | CE04028 |
| | | Other_name | CELE_C17C3.8 | Accession_evidence | NDB | BX284602 |
| | | Public_name | hlh-26 |
| | DB_info | Database | AceView | gene | 2F822 |
| | | | WormQTL | gene | WBGene00001965 |
| | | | WormFlux | gene | WBGene00001965 |
| | | | NDB | locus_tag | CELE_C17C3.8 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001965|UniProtKB=Q18053 |
| | | | | family | PTHR10985 |
| | | | NCBI | gene | 173939 |
| | | | RefSeq | protein | NM_062661.7 |
| | | | SwissProt | UniProtAcc | Q18053 |
| | | | TREEFAM | TREEFAM_ID | TF322171 |
| | | | UniProt_GCRP | UniProtAcc | Q18053 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | hlh |
| | Allele (21) |
| | Strain | WBStrain00032036 |
| | | WBStrain00033856 |
| | RNASeq_FPKM (74) |
| | GO_annotation (11) |
| | Ortholog (17) |
| | Paralog | WBGene00001964 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00001968 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00001967 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00001966 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | hlh-26 encodes a REF-1-like protein with two bHLH domains that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-27, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-27, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-26 may require UNC-37; HLH-26's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; HLH-26 is not visibly expressed in EMS descendants, and has no obvious function in mass RNAi assays. | Paper_evidence | WBPaper00025235 |
| | | | | | WBPaper00031196 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 18 Apr 2008 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in ABpla; ABplp; ABpra; and ABprp. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C17C3.8 |
| | Corresponding_transcript | C17C3.8.1 |
| | Associated_feature | WBsf978584 |
| | Transcription_factor | WBTranscriptionFactor000073 |
| Experimental_info | RNAi_result | WBRNAi00084010 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00028995 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00040786 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00022289 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00107447 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr8069 |
| | | Expr10328 |
| | | Expr10329 |
| | | Expr1017022 |
| | | Expr1144825 |
| | | Expr2012501 |
| | | Expr2030740 |
| | Drives_construct | WBCnstr00005216 |
| | | WBCnstr00015259 |
| | | WBCnstr00036555 |
| | Construct_product | WBCnstr00005216 |
| | | WBCnstr00036555 |
| | Regulate_expr_cluster | WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | Microarray_results (17) |
| | Expression_cluster | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00053888:drh-3(rrr2)_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00058598:mex-1(or286)_downregulated |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:RIB |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061424:Diet_MYb120_downregulated |
| | | WBPaper00061527:sre-33-ZK1025.1_8337 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_WT |
| | | cgc4489_group_9 |
| | | WBPaper00025032:cluster_134 |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(66_min) |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SET |
| | | [cgc5767]:expression_class_SE_pi(23_min) |
| | Interaction (145) |
| Map_info | Map | II | Position | -1.19632 | Error | 0.002366 |
| | Positive | Positive_clone | C17C3 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00025235 |
| | WBPaper00027287 |
| | WBPaper00027309 |
| | WBPaper00029033 |
| | WBPaper00030887 |
| | WBPaper00031196 |
| | WBPaper00034761 |
| | WBPaper00062585 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |