| WBGene00003247 | SMap | S_parent | Sequence | ZC504 |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | mig-15 | Person_evidence | WBPerson261 |
| | | Sequence_name | ZC504.4 |
| | | Molecular_name (12) |
| | | Other_name | qid-7 | Person_evidence | WBPerson1157 |
| | | | qid-8 | Person_evidence | WBPerson1157 |
| | | | CELE_ZC504.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | mig-15 |
| | DB_info | Database (14) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 04 Nov 2014 12:25:34 | WBPerson2970 | Event | Acquires_merge | WBGene00004262 |
| | | | | | | Name_change | Other_name | qid-7 |
| | | | 3 | 04 Nov 2014 12:27:29 | WBPerson2970 | Event | Acquires_merge | WBGene00004263 |
| | | | | | | Name_change | Other_name | qid-8 |
| | | Acquires_merge | WBGene00004263 |
| | | | WBGene00004262 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mig |
| | Allele (101) |
| | Legacy_information | [Hedgecock EM] QL migration resembles QR. Pleiotropic defects in hypodermis. |
| | | [C.elegansII] rh148 : QL migration resembles QR. Pleiotropic defects in hypodermis. [CF] |
| | Strain | WBStrain00024147 |
| | | WBStrain00024148 |
| | | WBStrain00028841 |
| | | WBStrain00028845 |
| | | WBStrain00028859 |
| | | WBStrain00004868 |
| | | WBStrain00004869 |
| | RNASeq_FPKM (74) |
| | GO_annotation (29) |
| | Ortholog (41) |
| | Paralog (27) |
| | Structured_description | Concise_description | mig-15 encodes the C. elegans ortholog of vertebrate Nck-interacting kinase (NIK) which belongs to the STE20/germinal center kinase (GCK) family; MIG-15 is required for normal axon pathfinding, and to inhibit premature branching of commissures; RNAi of mig-15 and pat-3, which encodes a beta1A integrins, results in similar axonal defects, and mutations in ina-1, which encodes an alpha integrin chain, enhances the commissural phenotype of mig-15 mutations; MIG-15 also regulates multiple aspects Q cell behavior, including initial Q cell polarization (direction of lamellipodium extension) and maintenance of that polarity, as well as migration of the Q cells and their descendants; genetic mosaic analyses indicate that MIG-15 likely acts cell autonomously at least in AQR and PQR to regulate their migration; MIG-15 physically interacts with the cytoplasmic domain of the beta1A integrin, PAT-3; loss of mig-15 results in increased synapse number and synaptic tiling defect in DA neurons. | Paper_evidence | WBPaper00005218 |
| | | | | | WBPaper00032247 |
| | | | | | WBPaper00026842 |
| | | | | | WBPaper00006110 |
| | | | | | WBPaper00054962 |
| | | | | Person_evidence | WBPerson3718 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 10 Oct 2018 00:00:00 |
| | | Automated_description | Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 |
| | | | | Curator_confirmed | WBPerson38202 |
| | | | | Date_last_updated | 04 Jun 2018 00:00:00 |
| | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) |
| | | DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) |
| | | DOID:0081216 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30765) |
| | | DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) |
| | | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) |
| | | DOID:2043 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) |
| Models_disease_asserted | WBDOannot00000550 |
| | WBDOannot00000551 |
| | WBDOannot00000555 |
| Molecular_info | Corresponding_CDS | ZC504.4a |
| | | ZC504.4b |
| | | ZC504.4c |
| | | ZC504.4d |
| | Corresponding_transcript (4) |
| | Other_sequence (61) |
| | Associated_feature (18) |
| Experimental_info | RNAi_result (21) |
| | Expr_pattern | Expr1844 |
| | | Expr8961 |
| | | Expr1027934 |
| | | Expr1031541 |
| | | Expr1162414 |
| | | Expr2013563 |
| | | Expr2031796 |
| | Drives_construct | WBCnstr00010481 |
| | | WBCnstr00013639 |
| | | WBCnstr00036163 |
| | Construct_product | WBCnstr00010481 |
| | | WBCnstr00022525 |
| | | WBCnstr00036163 |
| | Microarray_results (43) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049018:swsn-2.2(RNAi)_downregulated |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061527:chd-7_16664-jmjd-3.1 |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00066085:sin-3(syb2172)_upregulated |
| | | cgc4386_cluster_6_3 |
| | | WBPaper00005475:Aging-regulated |
| | | WBPaper00025032:cluster_17 |
| | | WBPaper00025032:cluster_154 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00050538:Fasting_upregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_B |
| | Interaction (111) |
| | Anatomy_function | WBbtf0783 |
| | | WBbtf0784 |
| | WBProcess | WBbiopr:00000082 |
| | | WBbiopr:00000107 |
| | | WBbiopr:00000111 |
| Map_info | Map | X | Position | 2.19018 | Error | 0.003698 |
| | Well_ordered |
| | Positive | Positive_clone | ZC504 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 3293 |
| | | | 3294 |
| | | | 3295 |
| | | | 3296 |
| | | | 4886 |
| | | | 4133 |
| Reference (46) |
| Method | Gene |
