| WBGene00004457 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | C01B7 |
| Identity | Version | 1 |
| | Name | CGC_name | rpm-1 | Person_evidence | WBPerson451 |
| | | Sequence_name | C01B7.6 |
| | | Molecular_name | C01B7.6 |
| | | | C01B7.6.1 |
| | | | CE06730 |
| | | Other_name | rpm-3 |
| | | | sam-1 |
| | | | sad-3 |
| | | | syd-3 |
| | | | CELE_C01B7.6 | Accession_evidence | NDB | BX284605 |
| | | Public_name | rpm-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | rpm |
| | Allele (126) |
| | Strain | WBStrain00005412 |
| | | WBStrain00001745 |
| | | WBStrain00029055 |
| | | WBStrain00029056 |
| | | WBStrain00031377 |
| | | WBStrain00005362 |
| | | WBStrain00037463 |
| | RNASeq_FPKM (74) |
| | GO_annotation (74) |
| | Ortholog (45) |
| | Paralog | WBGene00017190 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | rpm-1 encodes an E3 ubiquitin ligase that contains an N-terminal RCC1 (regulator of chromosome condensation)-like guanine nucleotide exchange factor (GEF) domain and that is orthologous to Drosophila highwire and murine Phr1; RPM-1 functions autonomously within several different types of neurons to regulate presynaptic differentiation; in regulating axon termination, RPM-1 acts through the GLO-4 guanine nucleotide exchange factor that positively regulates vesicular trafficking through GLO-1/Rab; in regulating synaptogenesis, RPM-1 functions as part of an SCF-like ubiquitin ligase complex that negatively regulates signaling through the DLK-1 MAP kinase cascade; RPM-1 is expressed in most, if not all, neurons from the comma stage of embryogenesis through adulthood; RPM-1 expression is also seen in the pharynx, coelomocytes, and distal tip cells; in neurons, RPM-1 localizes to presynaptic terminals. | Paper_evidence | WBPaper00004146 |
| | | | | | WBPaper00004147 |
| | | | | | WBPaper00024212 |
| | | | | | WBPaper00024955 |
| | | | | | WBPaper00030940 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 26 Nov 2007 00:00:00 |
| | | Automated_description | Enables mitogen-activated protein kinase kinase kinase binding activity; protein phosphatase binding activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intracellular signal transduction; regulation of neuron projection development; and regulation of synapse assembly. Located in axon; neuromuscular junction; and presynaptic periactive zone. Expressed in several structures, including coelomocyte; hermaphrodite distal tip cell; nerve ring; pharynx; and touch receptor neurons. Is an ortholog of human MYCBP2 (MYC binding protein 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C01B7.6 |
| | Corresponding_transcript | C01B7.6.1 |
| | Other_sequence (42) |
| | Associated_feature | WBsf669186 |
| | | WBsf669187 |
| | | WBsf669188 |
| | | WBsf669189 |
| | | WBsf234135 |
| | | WBsf234136 |
| | | WBsf234137 |
| Experimental_info | RNAi_result (11) |
| | Expr_pattern (15) |
| | Drives_construct | WBCnstr00000713 |
| | | WBCnstr00002560 |
| | | WBCnstr00006401 |
| | | WBCnstr00010055 |
| | | WBCnstr00021120 |
| | | WBCnstr00035471 |
| | Construct_product | WBCnstr00000717 |
| | | WBCnstr00006401 |
| | | WBCnstr00019627 |
| | | WBCnstr00021081 |
| | | WBCnstr00021082 |
| | | WBCnstr00021120 |
| | | WBCnstr00021121 |
| | | WBCnstr00035471 |
| | | WBCnstr00040000 |
| | | WBCnstr00041440 |
| | Antibody | WBAntibody00000282 |
| | | WBAntibody00001369 |
| | Microarray_results (30) |
| | Expression_cluster | WBPaper00029359_1166 |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1458 |
| | | WBPaper00029359_1546 |
| | | WBPaper00029359_1549 |
| | | WBPaper00029359_1557 |
| | | WBPaper00029359_1599 |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00041222:hlh-1(cc561)_upregulated |
| | | WBPaper00041222:unc-120(st364)_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045693:S.flexneri_upregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set2 |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056034:pals-25(jy9)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057140:pptr-1(tm3103)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RMED |
| | | WBPaper00061340:SIB |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_downregulated_germline |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062672:let-418(n3536)dcp-66(RNAi)_downregulated |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | cgc4386_cluster_6_5 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00024671:AFD_vs_AWB_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035429:UVC_downregulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00039866:ClassComp_daf-19_downregulated |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00040963:TA200_up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:environmental_prime |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (111) |
| | WBProcess | WBbiopr:00000117 |
| Map_info | Map | V | Position | 1.62029 | Error | 0.012923 |
| | Positive | Positive_clone | C01B7 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4092 |
| | | | 4093 |
| | | Pos_neg_data | 10723 |
| | | | 10724 |
| | | | 10725 |
| | | | 10726 |
| | | | 10727 |
| Reference (123) |
| Remark | Sequence connection from [Jin Y, Nonet M] |
| | old_name sam-1 becomes new_name rpm-1 from [Jin Y, Nonet M]. |
| | [email 93 from R. Lee and cgc4523] |
| | Sequence connection from [Zhen M] |
| Method | Gene |
