WormBase Tree Display for Gene: WBGene00006435

WBGene00006435 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F25G6
  Identity: Version: 2
    Name: CGC_name: stdh-4
      Sequence_name: F25G6.5
      Molecular_name: F25G6.5a
        F25G6.5a.1
        CE47137
        F25G6.5b
        CE52769
        F25G6.5b.1
      Other_name: tag-57 Person_evidence: WBPerson201
        CELE_F25G6.5 Accession_evidence: NDB BX284605
      Public_name: stdh-4
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 27 Nov 2007 15:17:26 WBPerson2970 Name_change: CGC_name: stdh-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: stdh
    Allele (28)
    Strain: WBStrain00002288
      WBStrain00035663
    RNASeq_FPKM (74)
    GO_annotation: 00003241
      00003242
      00003243
      00003244
      00028932
      00028933
    Ortholog (67)
    Paralog (38)
    Structured_description: Concise_description: stdh-4 encodes a putative steroid dehydrogenase expressed in larval and adult pharynx; STDH-4 is orthologous to human HSD17B3 (OMIM:605573, mutated in pseudohermaphroditism), HSD17B12 (OMIM:609574), and HSDL1, and paralogous to LET-767 and STDH-1/-3; STDH-4 has no obvious function in mass RNAi assays. Paper_evidence: WBPaper00006204
            WBPaper00006525
            WBPaper00031006
          Curator_confirmed: WBPerson567
          Date_last_updated: 26 Nov 2007 00:00:00
      Automated_description: Predicted to enable oxidoreductase activity. Predicted to be involved in fatty acid elongation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and Alzheimer's disease. Is an ortholog of human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5212)
      DOID:1923 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5212)
      DOID:0112248 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5212)
  Molecular_info: Corresponding_CDS: F25G6.5a
      F25G6.5b
    Corresponding_CDS_history: F25G6.5:wp230
    Corresponding_transcript: F25G6.5a.1
      F25G6.5b.1
    Other_sequence (11)
    Associated_feature: WBsf718354
      WBsf1000690
      WBsf1000691
      WBsf1000692
      WBsf1020052
  Experimental_info: RNAi_result: WBRNAi00045527 Inferred_automatically: RNAi_primary
      WBRNAi00013885 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1449
      Chronogram1662
      Expr5858
      Expr1012380
      Expr1149442
      Expr2016959
      Expr2035107
    Drives_construct: WBCnstr00002988
      WBCnstr00004487
      WBCnstr00037909
    Construct_product: WBCnstr00037909
    Microarray_results (18)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00046415:lithium_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050990:body-muscle_enriched
      WBPaper00050990:body-muscle_expressed
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00061527:srj-21-srh-32
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00065841:26_1
      WBPaper00065841:26_2
      WBPaper00065993:glp-1(e2141)_upregulated
      cgc4489_group_6
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00048989:N2_allantoin_upregulated
    Interaction (90)
  Map_info: Map: V Position: 1.4451 Error: 0.002002
    Positive: Positive_clone: F25G6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4869
    Pseudo_map_position
  Reference: WBPaper00018598
    WBPaper00038491
    WBPaper00042257
    WBPaper00055090
  Remark: Gene name created from parsing 'genotype' field from CGC strain information CGC_data_submission
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene