| WBGene00006448 | SMap | S_parent | Sequence | C16C10 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | glod-4 | Person_evidence | WBPerson4055 |
| | | Sequence_name | C16C10.10 |
| | | Molecular_name | C16C10.10 |
| | | | C16C10.10.1 |
| | | | CE01490 |
| | | Other_name | tag-73 | Person_evidence | WBPerson201 |
| | | | CELE_C16C10.10 | Accession_evidence | NDB | BX284603 |
| | | Public_name | glod-4 |
| | DB_info | Database | AceView | gene | 3F243 |
| | | | WormQTL | gene | WBGene00006448 |
| | | | WormFlux | gene | WBGene00006448 |
| | | | NDB | locus_tag | CELE_C16C10.10 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006448|UniProtKB=Q09253 |
| | | | | family | PTHR46466 |
| | | | NCBI | gene | 175530 |
| | | | RefSeq | protein | NM_065426.5 |
| | | | SwissProt | UniProtAcc | Q09253 |
| | | | TREEFAM | TREEFAM_ID | TF105801 |
| | | | UniProt_GCRP | UniProtAcc | Q09253 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 20 Jul 2007 11:50:19 | WBPerson2970 | Name_change | CGC_name | glod-1 |
| | | | | | | | Other_name | tag-73 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | glod |
| | Allele (16) |
| | Strain | WBStrain00003573 |
| | | WBStrain00035694 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00053090 |
| | | 00053091 |
| | | 00053092 |
| | | 00053093 |
| | Contained_in_operon | CEOP3152 |
| | Ortholog (36) |
| | Structured_description | Concise_description | glod-4 encodes a glyoxalase required for normal lifespan, orthologous to human GLOD4; GLOD-4 is expressed in the larval and adult pharynx, pharyngeal-intestinal valve, intestine, anal sphincter, seam cells, amphids, and neurons, and in the adult reproductive system; overexpression of GLOD-4 increases glyoxalase activity 200-fold, reduces oxidative stress markers, and extends lifespan, probably by removing methylglyoxal from mitochondrial proteins, while glod-4(RNAi) animals exhibit increased methylglyoxalation of mitochondrial proteins and reduced lifespan; GLOD-4 activity normally decreases in vivo with age, despite unchanged levels of glod-4 mRNA. | Paper_evidence | WBPaper00006525 |
| | | | | | WBPaper00031006 |
| | | | | | WBPaper00031464 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 31 Mar 2008 00:00:00 |
| | | Automated_description | Involved in determination of adult lifespan and methylglyoxal metabolic process. Expressed widely. Is an ortholog of human GLOD4 (glyoxalase domain containing 4). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C16C10.10 |
| | Corresponding_transcript | C16C10.10.1 |
| | Other_sequence (52) |
| | Associated_feature | WBsf224687 |
| Experimental_info | RNAi_result (13) |
| | Expr_pattern | Chronogram500 |
| | | Chronogram1707 |
| | | Expr5277 |
| | | Expr8050 |
| | | Expr1018742 |
| | | Expr1032626 |
| | | Expr1144720 |
| | | Expr2012109 |
| | | Expr2030345 |
| | Drives_construct | WBCnstr00000582 |
| | | WBCnstr00000583 |
| | | WBCnstr00004025 |
| | | WBCnstr00034352 |
| | Construct_product | WBCnstr00034352 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040285:H2S_24hr_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044578:4-day_reduced-humidity_upregulated_proteomics |
| | | WBPaper00044578:reduced-humidity_upregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045316:prg-1_downregulated_L2 |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00050015:ifg-1(RNAi)_downregulated |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053810:clk-1(qm30)_upregulated |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058955:heatshock_upregulated_CE |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00060084:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00060278:atp-2(RNAi)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061527:D1007.4-F33G12.2 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4489_group_4 |
| | | WBPaper00025032:cluster_3 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034661:AgNPs_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040184:hcf-1up_sir-2.1up_daf-2up |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041370:spg-7(RNAi)_upregulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00049538:atfs-1(et18)_upregulated |
| | | [cgc5767]:cluster_8 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(41_min) |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction (15) |
| Map_info | Map | III | Position | -3.77504 | Error | 0.009327 |
| | Positive | Positive_clone | C16C10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4785 |
| | Pseudo_map_position |
| Reference | WBPaper00031464 |
| | WBPaper00038491 |
| | WBPaper00039011 |
| | WBPaper00050335 |
| | WBPaper00050372 |
| | WBPaper00051612 |
| | WBPaper00053669 |
| | WBPaper00055090 |
| | WBPaper00055164 |
| | WBPaper00066034 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
