WormBase Tree Display for Gene: WBGene00006674

WBGene00006674 Evidence: Person_evidence: WBPerson655
  SMap: S_parent: Sequence: T01B4
  Identity: Version: 1
    Name: CGC_name: twk-21 Person_evidence: WBPerson655
      Sequence_name: T01B4.1
      Molecular_name: T01B4.1
        T01B4.1.1
        CE43241
      Other_name: twk-16 Person_evidence: WBPerson655
        CELE_T01B4.1 Accession_evidence: NDB BX284606
      Public_name: twk-21
    DB_info: Database: AceView gene XQ919
        WormQTL gene WBGene00006674
        WormFlux gene WBGene00006674
        NDB locus_tag CELE_T01B4.1
        Panther gene CAEEL|WormBase=WBGene00006674|UniProtKB=Q22042
          family PTHR11003
        NCBI gene 192078
        RefSeq protein NM_078253.3
        TrEMBL UniProtAcc Q22042
        UniProt_GCRP UniProtAcc Q22042
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: twk
    Allele (80)
    Legacy_information: [Thomas JH] twk for potassium channel family, type Twik (double P domain)
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (53)
    Paralog (47)
    Structured_description: Automated_description: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Is an ortholog of several human genes including KCNK2 (potassium two pore domain channel subfamily K member 2); KCNK4 (potassium two pore domain channel subfamily K member 4); and KCNK5 (potassium two pore domain channel subfamily K member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T01B4.1
    Corresponding_CDS_history: T01B4.1:wp196
    Corresponding_transcript: T01B4.1.1
    Other_sequence: BMC13183_1
      JI235454.1
      BM00255
      MA00688
      MAC00117_1
    Associated_feature: WBsf717415
  Experimental_info: RNAi_result: WBRNAi00017934 Inferred_automatically: RNAi_primary
      WBRNAi00052076 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1016385
      Expr1155706
      Expr2017648
      Expr2035788
    Drives_construct: WBCnstr00034223
    Construct_product: WBCnstr00034223
    Microarray_results (18)
    Expression_cluster: WBPaper00032528:L3_depleted
      WBPaper00035211:age-1_vs_N2_downregulated
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00049626:UNC-75_target
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00055013:spt-16(RNAi)_upregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_L3
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
      WBPaper00058598:mex-1(or286)_downregulated
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060871:M.humicola-extract_4h_regulated
      WBPaper00061340:Arcade_cell_anterior_and_posterior
      WBPaper00061527:srj-42-srw-113
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064532:pals-22(jy3)_upregulated
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:JU1400_N.ironsii_regulated
      WBPaper00065841:9_0
      WBPaper00065841:9_1
      WBPaper00065841:9_2
      WBPaper00065841:24_0
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_downregulated_N2
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      cgc4489_group_15
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00027111:rrf-3(pk1426)_upregulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00055899:nitroguanidine_regulated
      [cgc5376]:let-60(G12V)-regulated_genes
    Interaction (13)
  Map_info: Map: X Position: 23.7516
    Positive: Positive_clone: T01B4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
        ZK1251
    Pseudo_map_position
  Reference: WBPaper00013489
    WBPaper00019049
    WBPaper00026748
    WBPaper00038491
    WBPaper00041956
    WBPaper00052568
    WBPaper00055090
    WBPaper00062955
    WBPaper00064809
  Remark: twk-21 was connected to ZK1251.8 Person_evidence: WBPerson655
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene