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WormBase Tree Display for Gene: WBGene00006729

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Name Class

WBGene00006729EvidencePerson_evidenceWBPerson696
SMapS_parentSequenceK07B1
IdentityVersion2
NameCGC_nameucp-4Person_evidenceWBPerson696
Sequence_nameK07B1.3
Molecular_nameK07B1.3
K07B1.3.1
CE28591
K07B1.3.2
Other_nameslc-25A27Person_evidenceWBPerson555
CELE_K07B1.3Accession_evidenceNDBBX284605
Public_nameucp-4
DB_infoDatabaseAceViewgene5J815
WormQTLgeneWBGene00006729
WormFluxgeneWBGene00006729
NDBlocus_tagCELE_K07B1.3
PanthergeneCAEEL|WormBase=WBGene00006729|UniProtKB=O01883
familyPTHR45618
NCBIgene179315
RefSeqproteinNM_073013.8
TREEFAMTREEFAM_IDTF354328
TrEMBLUniProtAccO01883
UniProt_GCRPUniProtAccO01883
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
227 Apr 2016 13:43:44WBPerson2970Name_changeOther_nameslc-25A27
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classucp
Allele (35)
StrainWBStrain00031433
WBStrain00005332
RNASeq_FPKM (74)
GO_annotation00026043
00026044
00026045
00026046
00026047
00026048
00026049
Contained_in_operonCEOP5224
Ortholog (39)
Paralog (35)
Structured_descriptionConcise_descriptionucp-4 encodes an uncoupling protein related to mammalian mitochondrial uncoupling protein 4 (UCP4) also known as solute carrier family 25, member 27 (SLC25A27); UCP-4 is predicted to function to uncouple ATP production from electron transport and, consistent with this, ucp-4 mutant animals contain elevated ATP levels; ucp-4 activity is also required for normal rates of survival in response to cold treatment; a ucp-4::gfp promoter fusion is expressed in head and body wall muscles and in the pharynx.Paper_evidenceWBPaper00025191
Curator_confirmedWBPerson1843
Date_last_updated26 Oct 2011 00:00:00
Automated_descriptionPredicted to enable transmembrane transporter activity. Involved in response to cold. Predicted to be located in membrane. Expressed in head muscle; head neurons; hypodermis; pharyngeal muscle cell; and pharynx. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human SLC25A27 (solute carrier family 25 member 27).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:5419Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:21065)
Molecular_infoCorresponding_CDSK07B1.3
Corresponding_transcriptK07B1.3.1
K07B1.3.2
Other_sequence (19)
Associated_featureWBsf232240
Experimental_infoRNAi_result (12)
Expr_patternExpr3239
Expr13140
Expr1018423
Expr1032805
Expr1153813
Expr2017735
Expr2035874
Drives_constructWBCnstr00011244
WBCnstr00015681
WBCnstr00015682
WBCnstr00015923
WBCnstr00015925
WBCnstr00015927
WBCnstr00015929
WBCnstr00034190
WBCnstr00038589
WBCnstr00038590
Construct_productWBCnstr00034190
WBCnstr00038590
Microarray_results (20)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00035073:mitochondria_protein
WBPaper00035269:cde-1_regulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00040221:DAF-12_target_ALF4
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(gk119)_downregulated
WBPaper00045417:128Q-huntingtin_upreglated
WBPaper00045521:Oogenic
WBPaper00045571:germline-ablation_downregulated
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00051039:germline_enriched
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053295:lin-22(ot267)_downregulated
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056165:MINA-1_interacting_mRNA
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:sin-3(tm1276)_upregulated
WBPaper00058691:cfp-1(tm6369)_upregulated
WBPaper00058691:sin-3(tm1276)_upregulated
WBPaper00059471:EGL-43_interacting
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00061203:let-418(n3536)_downregulated
WBPaper00061203:sin-3(tm1276)_downregulated
WBPaper00061203:spr-1(ok2144)_downregulated
WBPaper00061340:AIN_parent
WBPaper00061527:F31C3.4_6048-cutc-1_15804
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064502:spe-44(fx110)_upregulated
WBPaper00064716:paraquat_upregulated
WBPaper00065096:25C_vs_20C_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065975:P-body_vs_WholeAnimal_enriched
cgc4386_cluster_4_3
cgc4489_group_2
WBPaper00025032:cluster_8
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035905:FBF-1_Associated
WBPaper00036286:Pattern_B
WBPaper00040963:TA100_down
WBPaper00040963:TA200_down
WBPaper00040963:TA300_down
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045263:ProLongevity-mtROS_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:cluster_1
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MD_pd(41_min)
[cgc5767]:expression_class_MD_pd(53_min)
[cgc5767]:expression_class_SM
[cgc5767]:expression_class_SMD
[cgc6390]:mixed_oogenesis-somatic
Interaction (17)
Map_infoMapVPosition1.99099Error0.001988
PositivePositive_cloneK07B1Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4426
5091
Pseudo_map_position
Reference (18)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene