ucp-4 encodes an uncoupling protein related to mammalian mitochondrial uncoupling protein 4 (UCP4) also known as solute carrier family 25, member 27 (SLC25A27); UCP-4 is predicted to function to uncouple ATP production from electron transport and, consistent with this, ucp-4 mutant animals contain elevated ATP levels; ucp-4 activity is also required for normal rates of survival in response to cold treatment; a ucp-4::gfp promoter fusion is expressed in head and body wall muscles and in the pharynx.
Predicted to enable transmembrane transporter activity. Involved in response to cold. Predicted to be located in membrane. Expressed in head muscle; head neurons; hypodermis; pharyngeal muscle cell; and pharynx. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human SLC25A27 (solute carrier family 25 member 27).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.