| WBGene00008765 | SMap | S_parent | Sequence | F13G3 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | ttx-7 | Person_evidence | WBPerson433 |
| | | Sequence_name | F13G3.5 |
| | | Molecular_name | F13G3.5a |
| | | | F13G3.5a.1 |
| | | | CE47972 |
| | | | F13G3.5b |
| | | | CE48079 |
| | | | F13G3.5a.2 |
| | | | F13G3.5b.1 |
| | | Other_name | CELE_F13G3.5 | Accession_evidence | NDB | BX284601 |
| | | Public_name | ttx-7 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 31 Jan 2007 13:58:31 | WBPerson2970 | Name_change | CGC_name | ttx-7 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ttx |
| | Allele (30) |
| | Strain | WBStrain00032133 |
| | | WBStrain00032183 |
| | | WBStrain00022002 |
| | | WBStrain00022001 |
| | | WBStrain00021999 |
| | RNASeq_FPKM (74) |
| | GO_annotation (28) |
| | Contained_in_operon | CEOP1388 |
| | Ortholog (42) |
| | Paralog | WBGene00012390 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00044063 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | ttx-7 encodes, by alternative splicing, two isoforms of a myo-inositolmonophosphatase (IMPase) required for normal thermotaxis and chemotaxisto sodium, as well as for subcellular localization of SNB-1 and SNG-1 inRIA interneurons; one isoform ('ttx-7a') has much higher transgenicrescuing activity of ttx-7(nj40) than the other ('ttx-7b'), so ttx-7a isconsidered the major isoform in vivo; a rescuing translational fusion ofTTX-7 to EGFP is strongly expressed in coelomocytes and a few head andtail neurons, with weaker expression in motor neurons, intestine, andsomatic gonad; TTX-7::EGFP is cytoplasmic, and can rescue mutantphenotypes when transiently expressed in adults; TTX-7 proteins areorthologous to human IMPA1 (OMIM:602064) and IMPA2 (OMIM:605922),possible mediators of manic depressive psychosis; ttx-7 mutationsdisplay ahtermic and chemotactic phenotypes, partially suppress thethermophilic phenotype of tax-6 mutations, and cause mislocalization ofSNB-1 and SNG-1; while ttx-7 expression is required in RIA to rescuethermotaxis phenotypes, RIA in ttx-7 mutants is morphologically normal;ttx-7 mutant phenotypes can be rescued by exogenous inositol applied toadults; ttx-7 mutations can be phenocopied in wild-type worms by lithiumtreatment of adults, and this phenocopy can be suppressed byoverexpression of a ttx-7 transgene, or by exogenous inositol orsorbitol; ttx-7 mutant development is delayed by exogenous galactose,implying a link between TTX-7/IMPase and galactose metabolism. | Paper_evidence | WBPaper00028886 |
| | | | | | WBPaper00029230 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 04 Apr 2007 00:00:00 |
| | | Automated_description | Predicted to enable inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in chemotaxis; protein localization to synapse; and thermotaxis. Located in cytoplasm. Expressed in several structures, including coelomocyte; gonad; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; and schizophrenia. Is an ortholog of human IMPA1 (inositol monophosphatase 1) and IMPA2 (inositol monophosphatase 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6051) |
| | | DOID:0081221 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6050) |
| | | DOID:1059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6050) |
| | | DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6051) |
| Molecular_info | Corresponding_CDS | F13G3.5a |
| | | F13G3.5b |
| | Corresponding_CDS_history | F13G3.5:wp68 |
| | | F13G3.5a:wp176 |
| | | F13G3.5b:wp176 |
| | Corresponding_transcript | F13G3.5a.1 |
| | | F13G3.5a.2 |
| | | F13G3.5b.1 |
| | Other_sequence (66) |
| | Associated_feature | WBsf649306 |
| | | WBsf663810 |
| | | WBsf664431 |
| | | WBsf976775 |
| | | WBsf976776 |
| | | WBsf976777 |
| | | WBsf976778 |
| | | WBsf219736 |
| Experimental_info | RNAi_result | WBRNAi00003372 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00044539 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00116918 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00030906 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr3894 |
| | | Expr4403 |
| | | Expr1027404 |
| | | Expr1033823 |
| | | Expr1148493 |
| | | Expr2017630 |
| | | Expr2035770 |
| | Drives_construct | WBCnstr00011726 |
| | | WBCnstr00011971 |
| | | WBCnstr00032706 |
| | Construct_product | WBCnstr00011971 |
| | | WBCnstr00032706 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_embryo_enriched |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_upregulated_HeatShock |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048926:miaserin_upregulated_adult-day5 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061340:ADF |
| | | WBPaper00061340:ADF_AWB |
| | | WBPaper00061340:Coelomocyte |
| | | WBPaper00061340:hmc_homolog |
| | | WBPaper00061340:OLQ |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061527:C28H8.4-ZK418.5_10918 |
| | | WBPaper00061651:Coelomocyte_enriched |
| | | WBPaper00061651:RIA_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062590:Aging_downregulated_hypodermis |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00065158:25C_vs_15C_upregulated_AFD |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00025032:cluster_19 |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027342:alpha-Synuclein(WT)_upregulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034757:down_by_oxidative_stress |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_3 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(186_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(53_min) |
| | | [cgc5767]:expression_class_MD_pd(66_min) |
| | | [cgc5767]:expression_class_ME |
| | Interaction (94) |
| Map_info | Map | I | Position | 1.88331 | Error | 0.002966 |
| | Positive | Positive_clone | F13G3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (19) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
