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WormBase Tree Display for Gene: WBGene00011867

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Name Class

WBGene00011867SMapS_parentSequenceT20G5
IdentityVersion3
NameCGC_namechc-1Person_evidenceWBPerson217
Sequence_nameT20G5.1
Molecular_nameT20G5.1
T20G5.1.1
CE00480
Other_nameclhc-1Paper_evidenceWBPaper00031805
CELE_T20G5.1Accession_evidenceNDBBX284603
Public_namechc-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:53WBPerson1971EventImportedInitial conversion from CDS class of WS125
204 Nov 2004 16:11:20WBPerson2970Name_changeCGC_namechc-1
330 Apr 2008 14:28:36WBPerson2970Name_changeOther_nameclhc-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classchc
Allele (82)
Possibly_affected_byWBVar02153072
WBVar00000423
StrainWBStrain00037310
WBStrain00005825
RNASeq_FPKM (74)
GO_annotation (34)
Contained_in_operonCEOP3858
Ortholog (47)
Structured_descriptionConcise_descriptionchc-1 encodes the C. elegans clathrin heavy chain ortholog; loss of chc-1 activity via RNAi results in defects in receptor-mediated yolk endocytosis and thus, embryonic lethality.Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson1843
Date_last_updated21 Mar 2008 00:00:00
Automated_descriptionPredicted to enable clathrin light chain binding activity. Involved in several processes, including apical protein localization; determination of adult lifespan; and positive regulation of clathrin-dependent endocytosis. Located in cell periphery; clathrin-coated endocytic vesicle; and mitotic spindle. Expressed in coelomocyte; germ line; hyp7 syncytium; hypodermal cell; and pharyngeal cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Is an ortholog of human CLTC (clathrin heavy chain) and CLTCL1 (clathrin heavy chain like 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0080226Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2092)
Molecular_infoCorresponding_CDST20G5.1
Corresponding_transcriptT20G5.1.1
Other_sequence (98)
Associated_featureWBsf659485
WBsf659486
WBsf993933
WBsf993934
WBsf1015749
WBsf225683
Experimental_infoRNAi_result (68)
Expr_pattern (13)
Drives_constructWBCnstr00000149
WBCnstr00017705
WBCnstr00030323
Construct_product (16)
AntibodyWBAntibody00000734
WBAntibody00001390
Microarray_results (19)
Expression_clusterWBPaper00032528:L3_enriched
WBPaper00035073:mitochondria_protein
WBPaper00037047:insoluble_protein
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038289:oocyte_protein
WBPaper00040221:DAF-12_target_ALF4
WBPaper00040446:insoluble_protein
WBPaper00040965:lipid-droplet_associated_protein
WBPaper00041072:UTX-1_interacting_protein
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044037:eat-2_downregulated
WBPaper00044128:daf-2(e1370)_upregulated
WBPaper00044128:DietaryRestriction_upregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046509:htz-1(ok3099)_upregulated
WBPaper00048910:mRNA-interacting_protein
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00050015:ifg-1(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050514:CEBP-1_interacting
WBPaper00050636:aging_regulated_insoluble_protein
WBPaper00050698:DEP-1_interacting
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051265:F1_morc-1(tm6048)_downregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
WBPaper00053810:clk-1(qm30)_downregulated
WBPaper00053810:isp-1(qm150)_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00053814:25C_downregulated_PY79
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055565:AVK_enriched
WBPaper00055626:pry-1(mu38)_upregulated
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
WBPaper00056900:PID-3_interacting
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:CFP-1_interacting_protein
WBPaper00059174:MEG-3_interacting
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059328:mrps-5(RNAi)_downregulated_protein
WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
WBPaper00059471:EGL-43_interacting
WBPaper00059605:MUT-16_interacting
WBPaper00059763:neuron_expressed
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061340:Coelomocyte
WBPaper00061377:MYRF-1_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:dld-1-skn-1_16701
WBPaper00061651:Coelomocyte_enriched
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
WBPaper00064055:trl-1(cas1077)_upregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064122:vulva_transcriptome
WBPaper00064201:SNA-3_interacting
WBPaper00064257:UNG-1_interacting
WBPaper00064505:tamoxifen_upregulated
WBPaper00064716:paraquat_upregulated
WBPaper00064871:hypoxia_upregulated_F1
WBPaper00065120:body-muscle-transcriptome
WBPaper00065258:anchor-cell_enriched
cgc4489_group_24
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00030985:Serratia_marcesens_downregulated
WBPaper00032948:FedUp
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Fluoranthene_regulated
WBPaper00039835:ifg-1_upregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040821:Au-NP_regulated
WBPaper00040823:alg-1(gk214)_downregulated
WBPaper00040963:TA300_down
WBPaper00041002:HF_11d_2.0mM_Up
WBPaper00041174:environmental
WBPaper00041174:genotypic
WBPaper00041174:genotypic_and_environmental
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00042331:a-SWCNTs_downregulated
Interaction (243)
Map_infoMapIIIPosition2.01234Error0.001699
PositivePositive_cloneT20G5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (42)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene