WormBase Tree Display for Gene: WBGene00014228

WBGene00014228 SMap: S_parent: Sequence: ZK1128
  Identity: Version: 3
    Name: CGC_name: mett-10 Person_evidence: WBPerson555
            WBPerson3341
            WBPerson728
      Sequence_name: ZK1128.2
      Molecular_name: ZK1128.2a
        ZK1128.2a.1
        CE31860
        ZK1128.2b
        CE31861
        ZK1128.2b.1
      Other_name: let-42 Person_evidence: WBPerson533
        stu-18 Person_evidence: WBPerson261
        CELE_ZK1128.2 Accession_evidence: NDB BX284603
      Public_name: mett-10
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 03 Jul 2009 09:33:38 WBPerson1847 Event: Acquires_merge: WBGene00002317
        3 03 Jul 2009 09:53:47 WBPerson1847 Event: Acquires_merge: WBGene00006303
      Acquires_merge: WBGene00002317
        WBGene00006303
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mett
    Allele (29)
    Legacy_information: g38 has a leaky maternal effect lethal phenotype at 25oC. Animals which develop to adulthood are sterile and frequently have a protruding vulva. oz36 has a similar phenotype at 25oC. In addition, oz36 has an incompletely penetrant late-onset tumorous germline phenotype that is most prevalent at 15oC.
      [C.elegansII] g38 : leaky maternal effect lethal phenotype at 25C. Animals which develop to adulthood are sterile, frequently Evl. OA1: oz36 (similar phenotype at 25C, also impenetrant late-onset tumorous germline phenotype,strongest at 15C. oz36 males exhibit some tumorous germ lines, some oogenesis and yolk synthesis). [RC; BS]
    Complementation_data: oz36 fails to complement let-42(g38)
    Strain: WBStrain00033310
      WBStrain00036838
      WBStrain00040363
      WBStrain00007835
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (31)
    Structured_description: Automated_description: Enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity and mRNA (N6-adenosine)-methyltransferase activity. Involved in several processes, including centrosome cycle; regulation of gene expression; and vulval development. Located in nucleus. Expressed in germ line; gonad; intestine; and vulva. Is an ortholog of human METTL16 (methyltransferase 16, RNA N6-adenosine). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK1128.2a
      ZK1128.2b
    Corresponding_CDS_history: ZK1128.2:wp85
    Corresponding_transcript: ZK1128.2a.1
      ZK1128.2b.1
    Other_sequence (18)
    Associated_feature: WBsf645538
      WBsf225662
      WBsf225663
  Experimental_info: RNAi_result: WBRNAi00059139 Inferred_automatically: RNAi_primary
      WBRNAi00006294 Inferred_automatically: RNAi_primary
      WBRNAi00038163 Inferred_automatically: RNAi_primary
      WBRNAi00021822 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8658
      Expr8835
      Expr1019103
      Expr1036379
      Expr1162563
      Expr2013539
      Expr2031773
    Drives_construct: WBCnstr00005679
      WBCnstr00005783
      WBCnstr00005784
      WBCnstr00005785
      WBCnstr00005786
      WBCnstr00005787
      WBCnstr00005788
      WBCnstr00006668
      WBCnstr00007536
      WBCnstr00029210
    Construct_product: WBCnstr00005679
      WBCnstr00005783
      WBCnstr00005784
      WBCnstr00005785
      WBCnstr00005786
      WBCnstr00005787
      WBCnstr00005788
      WBCnstr00006668
      WBCnstr00007536
      WBCnstr00029210
    Regulate_expr_cluster: WBPaper00061357:mett-10(ok2204)_downregulated_NA22
      WBPaper00061357:mett-10(ok2204)_downregulated_OP50
      WBPaper00061357:mett-10(ok2204)_upregulated_NA22
      WBPaper00061357:mett-10(ok2204)_upregulated_OP50
    Microarray_results (25)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00037946:MAB-5_interacting
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061527:F54E7.8-orc-5_6376
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065945:global-rpoa-2(-)_upregulated_transcript
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025032:cluster_76
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00030985:Erwinia_carotovora_downregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_9
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:male_germline-enriched
    Interaction (42)
  Map_info: Map: III Position: 1.83558 Error: 0.005596
    Positive: Positive_clone: ZK1128 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 607
        608
      Multi_point: 506
        507
        3173
        3175
        3176
        3177
        3178
  Reference (14)
  Method: Gene