WormBase Tree Display for Gene: WBGene00015943

WBGene00015943 SMap: S_parent: Sequence: C18A3
  Identity: Version: 2
    Name: CGC_name: tiar-1 Person_evidence: WBPerson1352
      Sequence_name: C18A3.5
      Molecular_name: C18A3.5a
        C18A3.5a.1
        CE27708
        C18A3.5b
        CE27709
        C18A3.5c
        CE27710
        C18A3.5b.1
        C18A3.5c.1
      Other_name: CELE_C18A3.5 Accession_evidence: NDB BX284602
      Public_name: tiar-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:56 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 03 Aug 2010 10:05:58 WBPerson2970 Name_change: CGC_name: tiar-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tiar
    Allele (39)
    Strain: WBStrain00002273
      WBStrain00001558
      WBStrain00005716
      WBStrain00005719
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog (44)
    Paralog (14)
    Structured_description: Automated_description: Predicted to enable mRNA binding activity. Involved in several processes, including determination of adult lifespan; nematode larval development; and response to UV. Located in P granule; cytoplasmic stress granule; and nucleus. Expressed in several structures, including germ line; hypodermis; mechanosensory neurons; somatic cell; and tail. Is an ortholog of human TIA1 (TIA1 cytotoxic granule associated RNA binding protein) and TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0081380 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11802)
      EFO:MONDO:0018949 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11802)
  Molecular_info: Corresponding_CDS: C18A3.5a
      C18A3.5b
      C18A3.5c
    Corresponding_CDS_history: C18A3.5d:wp88
      C18A3.5e:wp275
      C18A3.5f:wp275
    Corresponding_transcript: C18A3.5a.1
      C18A3.5b.1
      C18A3.5c.1
    Other_sequence (127)
    Associated_feature: WBsf650084
      WBsf650085
      WBsf665551
      WBsf665552
      WBsf223086
      WBsf223087
  Experimental_info: RNAi_result (18)
    Expr_pattern (15)
    Drives_construct: WBCnstr00002398
      WBCnstr00004330
      WBCnstr00009614
      WBCnstr00009615
      WBCnstr00018197
      WBCnstr00019821
      WBCnstr00019822
      WBCnstr00022507
      WBCnstr00028437
    Construct_product: WBCnstr00018197
      WBCnstr00019821
      WBCnstr00022506
      WBCnstr00022507
      WBCnstr00028437
    Antibody: WBAntibody00002448
    Microarray_results (46)
    Expression_cluster: WBPaper00026640:Development_Group_VI
      WBPaper00029359_1166
      WBPaper00029359_1197
      WBPaper00029359_1291
      WBPaper00029359_1439
      WBPaper00029359_1458
      WBPaper00029359_1546
      WBPaper00029359_1549
      WBPaper00029359_1557
      WBPaper00029359_1599
      WBPaper00032425:up_in_alg-1
      WBPaper00032425:up_in_zfp-1
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049626:UNC-75_target
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051310:LIN-41_interacting
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053039:Aspirin_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00059174:MEG-3_interacting
      WBPaper00059254:CSR-1_interacting
      WBPaper00059254:PRG-1_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061466:nath-10(icb102)_downregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:cdc-42_17192-rab-5_18073
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00062123:DEPS-1_interacting
      WBPaper00062123:GLH-1_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00064071:NHR-49_interacting
      WBPaper00064080:let-7_miRNA_interacting
      WBPaper00064163:ZNFX-1_interacting_young-adult
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F2
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:AFD_depleted
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      cgc4489_group_4
      WBPaper00025032:cluster_30
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2lessDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00037695:DD_3-day
      WBPaper00037695:LD_3-day
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_E_pi(101_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (47)
  Map_info: Map: II Position: -0.964172 Error: 0.002386
    Positive: Positive_clone: C18A3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene