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WormBase Tree Display for Gene: WBGene00016038

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Name Class

WBGene00016038SMapS_parentSequenceC24A8
IdentityVersion3
NameCGC_namecst-2Person_evidenceWBPerson1787
Sequence_nameC24A8.4
Molecular_nameC24A8.4
C24A8.4.1
CE27082
Other_nametag-306
CELE_C24A8.4Accession_evidenceNDBBX284606
Public_namecst-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:30:56WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
222 Apr 2005 11:55:18WBPerson2970Name_changeCGC_nametag-306
330 Jun 2006 11:52:50WBPerson2970Name_changeCGC_namecst-2
Other_nametag-306
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcst
AlleleWBVar02121349
WBVar02123953
WBVar02122727
WBVar01499636
WBVar02123331
WBVar01500067
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (33)
Paralog (27)
Structured_descriptionConcise_descriptioncst-2 encodes a protein kinase that is the C. elegans ortholog of the MST (mammalian Ste20-like) kinases and Drosophila Hippo; CST-2 appears to play a role in the responses to oxidative stress and determination of adult lifespan; in regulating stress response and lifespan, CST-2 functions upstream of the DAF-16/FOXO transcription factor; CST-2 physically interacts with RSF-1, the C. elegans homolog of the Ras-association domain family protein 1.Paper_evidenceWBPaper00041685
Curator_confirmedWBPerson1843
Date_last_updated12 Mar 2013 00:00:00
Automated_descriptionPredicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and regulation of MAPK cascade. Predicted to be located in cytoplasm. Expressed in AQR and PQR. Is an ortholog of human STK3 (serine/threonine kinase 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC24A8.4
Corresponding_CDS_historyC24A8.4:wp187
C24A8.4a:wp144
C24A8.4a:wp150
C24A8.4b:wp150
Corresponding_transcriptC24A8.4.1
Other_sequenceFC539669.1
JI478861.1
CJC01973_1
JI483962.1
CRC08211_1
SSC03642_1
SS00169
Associated_featureWBsf1004906
WBsf1022767
WBsf237275
Experimental_infoRNAi_result (17)
Expr_patternExpr13232
Expr1027759
Expr1145097
Expr2010563
Expr2028803
Drives_constructWBCnstr00028372
WBCnstr00038936
Construct_productWBCnstr00028372
WBCnstr00038936
Microarray_results (27)
Expression_clusterWBPaper00024375:Up_vhl-1_vs_hif-1_vhl-1
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040221:DAF-12_target_ALF4
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00045521:Oogenic
WBPaper00048971:daf-16(mgDf50)_downregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00050344:ASER-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:body-muscle_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:pharynx_expressed
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00055354:Metformin_upregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056826:SGP_biased
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00059763:neuron_expressed
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060661:sensory-neuron_enriched
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:FLP
WBPaper00061340:PVR
WBPaper00061340:RID_parent
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00064122:vulva_transcriptome
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064788:ketamine_upregulated
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
WBPaper00065749:Heat-Shock_upregulated_N2
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066110:Doxorubicin_downregulated_tetraploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4489_group_8
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00025032:cluster_12
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031003:hlh_1_enriched
WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
WBPaper00037695:WC_5-day
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040858:eQTL_regulated_old
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041960:daf-16_fasting_upregulated
WBPaper00041960:jun-1_fasting_upregulated
WBPaper00041960:kgb-1_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00048637:lin-35(n745)_starvation_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc6390]:Cluster_A
Interaction (20)
Map_infoMapXPosition-7.78254Error0.002352
PositivePositive_cloneC24A8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5184
Pseudo_map_position
ReferenceWBPaper00006132
WBPaper00027662
WBPaper00038491
WBPaper00041685
WBPaper00041976
WBPaper00046758
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene