| WBGene00020490 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | tmc-1 | Person_evidence | WBPerson260 |
| | | Sequence_name | T13G4.3 |
| | | Molecular_name | T13G4.3 |
| | | | T13G4.3.1 |
| | | | CE37147 |
| | | | T13G4.3.2 |
| | | Other_name | R193.f | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | T13G4.e | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | CELE_T13G4.3 | Accession_evidence | NDB | BX284606 |
| | | Public_name | tmc-1 |
| | DB_info | Database | AceView | gene | XB793 |
| | | | WormQTL | gene | WBGene00020490 |
| | | | WormFlux | gene | WBGene00020490 |
| | | | NDB | locus_tag | CELE_T13G4.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00020490|UniProtKB=D3KZG3 |
| | | | | family | PTHR23302 |
| | | | NCBI | gene | 188483 |
| | | | RefSeq | protein | NM_075820.9 |
| | | | SwissProt | UniProtAcc | D3KZG3 |
| | | | UniProt_GCRP | UniProtAcc | D3KZG3 |
| | | | OMIM | gene | 606706 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 20 Apr 2011 10:05:24 | WBPerson2970 | Name_change | CGC_name | tmc-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | tmc |
| | Allele (278) |
| | Strain | WBStrain00032242 |
| | | WBStrain00004936 |
| | RNASeq_FPKM (74) |
| | GO_annotation (17) |
| | Ortholog (40) |
| | Paralog | WBGene00015177 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | tmc-1 encodes a multipass transmembrane protein; TMC-1 functions specifically as a sodium-sensitive channel that is required for salt taste chemosensation in the ASH neurons and for high salt avoidance behavior; when expressed in other neurons, TMC-1 is sufficient to generate a salt response in vivo, and when expressed in mammalian cells, TMC-1 generates a predominantly cationic current activated by high extracellular sodium but not other cations or uncharged small molecules; tmc-1 is expressed in sensory neurons, including the ASH, ADF, ASE, ADL, AQR, PQR, URX, and PHA neurons and also at lower frequency in AWC, AFD, and BAG; in ASH, TMC-1 localizes to the cell soma as well as the sensory cilium. | Paper_evidence | WBPaper00041946 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 15 Feb 2013 00:00:00 |
| | | Automated_description | Enables sodium channel activity. Involved in detection of stimulus involved in sensory perception; monoatomic ion transmembrane transport; and sensory perception of chemical stimulus. Located in neuronal cell body; non-motile cilium; and plasma membrane. Expressed in body wall musculature; neurons; and in male. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Is an ortholog of human TMC3 (transmembrane channel like 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0110520 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16513) |
| | | DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16513) |
| | | DOID:0110563 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16513) |
| Molecular_info | Corresponding_CDS | T13G4.3 |
| | Corresponding_CDS_history | T13G4.3:wp88 |
| | | T13G4.3:wp128 |
| | Corresponding_transcript | T13G4.3.1 |
| | | T13G4.3.2 |
| | Other_sequence (22) |
| | Associated_feature (14) |
| Experimental_info | RNAi_result | WBRNAi00018692 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00053286 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00017899 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00009854 |
| | | WBCnstr00017536 |
| | | WBCnstr00020650 |
| | | WBCnstr00025101 |
| | | WBCnstr00040831 |
| | | WBCnstr00042184 |
| | | WBCnstr00042981 |
| | Construct_product | WBCnstr00017537 |
| | | WBCnstr00025101 |
| | | WBCnstr00040715 |
| | Regulate_expr_cluster | WBPaper00065746:tmc-1(rg1003)_downregulated |
| | | WBPaper00065746:tmc-1(rg1003)_upregulated |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:BAG-neuron_embryo_enriched |
| | | WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040285:H2S_24hr_downregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00047132:skn-1(RNAi)_downregulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055226:ADR-2_target_adr-1(tm668) |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:spc-1(cas971)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:MC |
| | | WBPaper00061340:NSM_parent |
| | | WBPaper00061340:OLQ |
| | | WBPaper00061340:Pharyngeal_neuron |
| | | WBPaper00061340:SIB |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:AVG_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:PHC_enriched |
| | | WBPaper00061651:PVN_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-1.2(zr1010)_upregulated |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064789:Day9_vs_Day1_upregulated_neuron |
| | | WBPaper00064789:Day12_vs_Day1_upregulated_neuron |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065841:6_1 |
| | | WBPaper00065841:6_2 |
| | | WBPaper00065841:6_3 |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:68_1 |
| | | WBPaper00065841:72_0 |
| | | WBPaper00065841:86_0 |
| | | WBPaper00065841:114_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:123_0 |
| | | WBPaper00065841:124_0 |
| | | WBPaper00065841:131_0 |
| | | WBPaper00065841:133_0 |
| | | WBPaper00065841:134_0 |
| | | WBPaper00065841:138_0 |
| | | WBPaper00065841:139_0 |
| | | WBPaper00065841:140_0 |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045294:50uM_TBBP_upregulated |
| | Interaction (13) |
| | Anatomy_function | WBbtf0953 |
| | | WBbtf0954 |
| | | WBbtf0956 |
| Map_info | Map | X | Position | -18.4825 |
| | Positive | Positive_clone | T13G4 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (19) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
