WormBase Tree Display for Gene: WBGene00021562

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WBGene00021562	SMap	S_parent	Sequence	CHROMOSOME_V
	Identity	Version	4
		Name	CGC_name	nuo-5	Person_evidence	WBPerson1157
			Sequence_name	Y45G12B.1
			Molecular_name	Y45G12B.1
				Y45G12B.1.1
				CE21933
			Other_name	nduf-1
				ndus-1	Person_evidence	WBPerson555
				CELE_Y45G12B.1	Accession_evidence	NDB	BX284605
			Public_name	nuo-5
		DB_info	Database	AceView	gene	5D185
				WormQTL	gene	WBGene00021562
				WormFlux	gene	WBGene00021562
				NDB	locus_tag	CELE_Y45G12B.1
				Panther	gene	CAEEL\|WormBase=WBGene00021562\|UniProtKB=Q9N4Y8
					family	PTHR11615
				NCBI	gene	178735
				RefSeq	protein	NM_071332.7
				TrEMBL	UniProtAcc	Q9N4Y8
				UniProt_GCRP	UniProtAcc	Q9N4Y8
				OMIM	gene	157655
		Species	Caenorhabditis elegans
		History	Version_change	1	28 May 2004 13:31:04	WBPerson1971	Event	Imported	Initial conversion from CDS class of stlace from WS125
				2	31 Aug 2005 14:07:05	WBPerson2970	Name_change	CGC_name	nuo-5
				3	26 Feb 2008 13:48:33	WBPerson2970	Name_change	Other_name	nduf-1
				4	16 Jan 2023 18:37:21	WBPerson51134	Name_change	Other_name	ndus-1
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	nuo
		Allele (265)
		RNASeq_FPKM (74)
		GO_annotation	00094987
			00094988
			00094989
			00094990
			00094991
			00094992
			00094993
			00125886
			00125887
			00125888
		Contained_in_operon	CEOP5032
		Ortholog (39)
		Paralog	WBGene00021902	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	nuo-5 is orthologous to human NADH-UBIQUINONE OXIDOREDUCTASE Fe-S PROTEIN 1 (NDUFS1; OMIM:157655), which when mutated leads to mitochondrial complex I deficiency.	Curator_confirmed	WBPerson1843
						WBPerson1823
						WBPerson567
					Date_last_updated	23 Mar 2010 00:00:00
			Automated_description	Predicted to enable 4 iron, 4 sulfur cluster binding activity; metal ion binding activity; and oxidoreductase activity, acting on NAD(P)H. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in cellular respiration. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex I. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 5. Is an ortholog of human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Experimental_model	DOID:700	Homo sapiens	Paper_evidence	WBPaper00064182
					Curator_confirmed	WBPerson324
					Date_last_updated	11 Oct 2022 00:00:00
		Potential_model	DOID:0060536	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:7707)
			DOID:0112068	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:7707)
			DOID:655	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:7707)
	Models_disease_in_annotation	WBDOannot00001329
		WBDOannot00001333
	Molecular_info	Corresponding_CDS	Y45G12B.1
		Corresponding_CDS_history	Y45G12B.1b:wp188
			Y45G12B.1b:wp262
			Y45G12B.1c:wp262
		Corresponding_transcript	Y45G12B.1.1
		Other_sequence (142)
		Associated_feature	WBsf661166
			WBsf661167
			WBsf661168
			WBsf231531
			WBsf231532
			WBsf231533
			WBsf231534
			WBsf231535
	Experimental_info	RNAi_result (13)
		Expr_pattern	Expr1012819
			Expr1039440
			Expr1160083
			Expr2014531
			Expr2032770
		Microarray_results (30)
		Expression_cluster	WBPaper00026640:Development_Group_I
			WBPaper00027022:tax-6(jh107)_downregulated
			WBPaper00032528:L3_enriched
			WBPaper00035073:mitochondria_protein
			WBPaper00035926:A.hydrophila_regulated
			WBPaper00037047:insoluble_protein
			WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
			WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
			WBPaper00037950:AVE-neuron_L1-larva_expressed
			WBPaper00037950:bodywall-muscle_L1-larva_expressed
			WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
			WBPaper00037950:hypodermis_L1-larva_expressed
			WBPaper00037950:intestine_L1-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
			WBPaper00038289:oocyte_protein
			WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
			WBPaper00040209:B.thuringiensis_downregulated_MY15
			WBPaper00040446:insoluble_protein
			WBPaper00040965:lipid-droplet_associated_protein
			WBPaper00040965:top50_lipid-droplet_associated_protein
			WBPaper00044501:gld-1_let-7_regulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044746:aging_downregulated_Day5
			WBPaper00044746:aging_downregulated_HeatShock
			WBPaper00045420:fertilization_downregulated_transcript
			WBPaper00045521:Gender_Neutral
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
			WBPaper00046509:htz-1(ok3099)_downregulated
			WBPaper00046509:lin-35(n745)_downregulated
			WBPaper00048923:Aging_regulated
			WBPaper00048988:neuron_expressed
			WBPaper00049498:npr-1(ur89)_regulated_3
			WBPaper00049545:jmjd-3.1(+)_downregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050599:nicotine(0.01mM)_upregulated
			WBPaper00050599:nicotine(1mM)_upregulated
			WBPaper00050636:aging_regulated_insoluble_protein
			WBPaper00050698:DEP-1_interacting
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050990:arcade_intestinal-valve_expressed
			WBPaper00050990:body-muscle_expressed
			WBPaper00050990:GABAergic-neuron_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00050990:NMDA-neuron_expressed
			WBPaper00050990:seam_expressed
			WBPaper00051245:body-wall-muscle_cytoplasm_expressed
			WBPaper00051245:epidermis_cytoplasm_expressed
			WBPaper00051245:epidermis_nucleus_expressed
			WBPaper00051245:intestine_cytoplasm_expressed
			WBPaper00051245:intestine_nucleus_expressed
			WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
			WBPaper00052884:emb-4(hc60)_downregulated
			WBPaper00053184:sma-2(rax5)_downregulated
			WBPaper00053184:sma-4(rax3)_downregulated
			WBPaper00053302:zidovudine_24h_regulated
			WBPaper00053388:dauer_regulated_Cluster6
			WBPaper00053615:SMO-1_target
			WBPaper00053810:daf-2(e1370)_downregulated
			WBPaper00053810:nuo-6(qm200)_upregulated
			WBPaper00055049:S.gordonii_upregulated
			WBPaper00055334:DLC-1_interacting
			WBPaper00055648:germline_expressed
			WBPaper00056161:male_enriched_siRNA
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
			WBPaper00056471:S.aureus-4h_upregulated_N2
			WBPaper00056501:P.aeruginosa_downregulated_mitochondria-protein
			WBPaper00056809:smn-1(ok355)_downregulated
			WBPaper00056900:PID-3_interacting
			WBPaper00057288:Cold_downregulated_transcript
			WBPaper00057288:iff-1(RNAi)_downregulated_transcript
			WBPaper00058691:cfp-1(tm6369)_upregulated
			WBPaper00058958:100mGy-irradiation-72h_upregulated
			WBPaper00059254:CSR-1_interacting
			WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
			WBPaper00059605:MUT-16_interacting
			WBPaper00060006:nfyb-1(cu13)_downregulated_protein
			WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi)
			WBPaper00060084:DVE-1_interacting_protein_control
			WBPaper00061341:28C_24h_downregulated
			WBPaper00061341:28C_48h_downregulated
			WBPaper00061377:MYRF-2_interacting
			WBPaper00061527:dld-1-skn-1_16701
			WBPaper00061527:hars-1-cct-4_20449
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062325:muscle_enriched_coding-RNA
			WBPaper00062498:PPM-1.D_interacting
			WBPaper00062554:MAGU-2_interacting
			WBPaper00062669:extracellular-vesicle_protein
			WBPaper00064071:NHR-49_interacting
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
			WBPaper00064201:SNA-3_interacting
			WBPaper00064315:mes-3(bn199)_downregulated_PGCs
			WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
			WBPaper00064933:E.coli-binding_secret_protein
			WBPaper00065120:body-muscle-transcriptome
			WBPaper00065149:lin-52(n771)_downregulated
			WBPaper00065158:AFD_depleted
			WBPaper00065373:sek-1(km4)_downregulated_cisplatin
			WBPaper00065373:sek-1(km4)_downregulated_Ref
			WBPaper00065975:P-body_vs_oocyte_depleted
			WBPaper00025032:cluster_28
			WBPaper00025032:cluster_31
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00031003:24hr_muscle_depleted
			WBPaper00031003:total_muscle_depleted
			WBPaper00031832:slr-2_regulated
			WBPaper00036286:Pattern_G
			WBPaper00038231:Cry5B_1.5-fold_downregulated
			WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
			WBPaper00040821:Au-NP_regulated
			WBPaper00041002:HF_11d_2.0mM_Up
			WBPaper00041606:CE_B.thuringiensis-DB27_regulated
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
			WBPaper00045263:nuo-6(qm200)_upregulated
			WBPaper00048989:N2_rapamycin_downregulated
		Interaction (103)
	Map_info	Map	V	Position	-13.3131	Error	0.011997
		Positive	Positive_clone	Y45G12B	Inferred_automatically	From sequence, transcript, pseudogene data
		Pseudo_map_position
	Reference (12)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene