| WBGene00022034 | SMap | S_parent | Sequence | Y65B4BL |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | deps-1 | Person_evidence | WBPerson632 |
| | | Sequence_name | Y65B4BL.2 |
| | | Molecular_name | Y65B4BL.2a |
| | | | Y65B4BL.2a.1 |
| | | | CE25536 |
| | | | Y65B4BL.2b |
| | | | CE49430 |
| | | | Y65B4BL.2b.1 |
| | | Other_name | CELE_Y65B4BL.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | deps-1 |
| | DB_info | Database | AceView | gene | 1A981 |
| | | | WormQTL | gene | WBGene00022034 |
| | | | WormFlux | gene | WBGene00022034 |
| | | | NDB | locus_tag | CELE_Y65B4BL.2 |
| | | | NCBI | gene | 171642 |
| | | | RefSeq | protein | NM_058341.6 |
| | | | | | NM_001306264.3 |
| | | | SwissProt | UniProtAcc | Q9N303 |
| | | | UniProt_GCRP | UniProtAcc | Q9N303 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 10 May 2007 14:24:04 | WBPerson2970 | Name_change | CGC_name | deps-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | deps |
| | Allele (44) |
| | Strain | WBStrain00033258 |
| | | WBStrain00034459 |
| | | WBStrain00005683 |
| | | WBStrain00022452 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00093439 |
| | | 00093440 |
| | | 00093441 |
| | | 00093442 |
| | Ortholog (25) |
| | Structured_description | Concise_description | deps-1 encodes an large (619-residue), unfamiliar P-granule-associated protein required for germline RNAi, PGL-1's localization in P granules, accumulation of GLH-1 and RDE-4 (along with glh-1 mRNA), germline proliferation and fertility at high temperatures, and embryonic viability at low temperatures; unless rescued by maternal DEPS-1, deps-1 mutants show temperature-sensitive sterility at 24+ deg. C., but remain fertile at 15-20 deg. C.; DEPS-1 upregulates 13 germline-expressed genes (including glh-1, rde-4, aco-2, cts-1, plk-3, and deps-1 itself), and downregulates 32 such genes (including dyf-3, klp-10, pvf-1, rnh-1.3, and ugt-64); DEPS-1 has a C-terminal serine-rich domain, and has orthologs in other Caenorhabditis species, but has no non-nematode orthologs. | Paper_evidence | WBPaper00031477 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 15 Feb 2008 00:00:00 |
| | | Automated_description | Predicted to be involved in regulatory ncRNA-mediated gene silencing. Located in P granule. Expressed in germ line and oocyte. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | Y65B4BL.2a |
| | | Y65B4BL.2b |
| | Corresponding_transcript | Y65B4BL.2a.1 |
| | | Y65B4BL.2b.1 |
| | Other_sequence | Tcir_isotig05964 |
| | | CRC07188_1 |
| | | CBC04710_1 |
| | | CR07679 |
| | Associated_feature | WBsf982516 |
| | | WBsf982517 |
| | | WBsf982518 |
| | | WBsf217136 |
| Experimental_info | RNAi_result | WBRNAi00026908 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00026909 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00057910 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00024249 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00004770 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00023372 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00023885 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00057905 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00024172 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00033344 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr7892 |
| | | Expr1018173 |
| | | Expr1039687 |
| | | Expr1161339 |
| | | Expr2010859 |
| | | Expr2029097 |
| | Regulate_expr_cluster | WBPaper00031477:Down_deps-1_vs_WT |
| | | WBPaper00031477:Up_deps-1_vs_WT |
| | | WBPaper00062123:DEPS-1_interacting |
| | Antibody | WBAntibody00001372 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:germline-precursors_embryo_enriched |
| | | WBPaper00037950:hypodermis_embryo_enriched |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:rising_dev_expression |
| | | WBPaper00044786:emr-1(gk119)_downregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045050:csr-1(hypomorph)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_downregulated |
| | | WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent |
| | | WBPaper00048611:MnCl2_downregulated |
| | | WBPaper00048657:plep-1(ttTi53821)_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050080:rbr-2(tm3141)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050686:glp-1(e2141)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00054191:H3.3(null)_L1_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059254:PRG-1_interacting |
| | | WBPaper00059254:WAGO-1_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061045:Y56A3A.22(cck200)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061340:Germline |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:T22D1.5-inx-14 |
| | | WBPaper00061753:csr-1(tor159)_downregulated_25C |
| | | WBPaper00062123:DEPS-1_interacting |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062446:nhr-8(hd117)_downregulated |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062590:Aging_downregulated_body-wall-muscle |
| | | WBPaper00062590:Aging_upregulated_neuron |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00063930:BRD-1_interacting |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064080:let-7_miRNA_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064163:ZNFX-1_interacting_embryo |
| | | WBPaper00064163:ZNFX-1_interacting_young-adult |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065984:pals-17(syb3980)_upregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_4_1 |
| | | cgc4489_group_2 |
| | | WBPaper00024393:strongly_regulated_dauer_genes |
| | | WBPaper00025032:cluster_1 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027342:alpha-Synuclein(WT)_upregulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031060:2-deoxy-D-glucose_downregulated |
| | | WBPaper00031477:Down_deps-1_vs_WT |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032165:A_to_C_transit_decreased |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00038060:SUMO-1_upregulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:cluster_1 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (156) |
| Map_info | Map | I | Position | -18.9833 | Error | 0.006079 |
| | Positive | Positive_clone | Y65B4BL | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00027804 |
| | WBPaper00031477 |
| | WBPaper00035324 |
| | WBPaper00043989 |
| | WBPaper00052166 |
| | WBPaper00057161 |
| | WBPaper00059254 |
| | WBPaper00060139 |
| | WBPaper00063892 |
| | WBPaper00064472 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
