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WormBase Tree Display for Gene: WBGene00022673

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Name Class

WBGene00022673SMapS_parentSequenceZK177
IdentityVersion2
NameCGC_namesahd-1Person_evidenceWBPerson555
Sequence_nameZK177.8
Molecular_name (18)
Other_nameCELE_ZK177.8Accession_evidenceNDBBX284602
Public_namesahd-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:06WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
213 Oct 2023 01:37:05WBPerson51134Name_changeCGC_namesahd-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsahd
Allele (76)
StrainWBStrain00001464
WBStrain00001188
WBStrain00003484
RNASeq_FPKM (74)
GO_annotation (18)
Ortholog (41)
Structured_descriptionAutomated_descriptionEnables dGTPase activity; deoxynucleoside triphosphate hydrolase activity; and protein homodimerization activity. Involved in dGTP catabolic process. Predicted to be located in nucleus. Expressed in head and tail. Human ortholog(s) of this gene implicated in several diseases, including Aicardi-Goutieres syndrome; Chilblain lupus; and hepatitis B. Is an ortholog of human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0060386Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:15925)
DOID:0050629Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:15925)
DOID:1883Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:15925)
DOID:9119Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:15925)
DOID:2043Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:15925)
Molecular_infoCorresponding_CDSZK177.8a
ZK177.8b
ZK177.8c
ZK177.8d
ZK177.8e
Corresponding_transcriptZK177.8a.1
ZK177.8a.2
ZK177.8b.1
ZK177.8b.2
ZK177.8b.3
ZK177.8c.1
ZK177.8d.1
ZK177.8e.1
Other_sequence (21)
Associated_featureWBsf650067
WBsf665533
WBsf665534
WBsf987898
WBsf223057
WBsf223058
Experimental_infoRNAi_resultWBRNAi00001766Inferred_automaticallyRNAi_primary
WBRNAi00038219Inferred_automaticallyRNAi_primary
WBRNAi00059260Inferred_automaticallyRNAi_primary
WBRNAi00021902Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00002080
WBCnstr00003942
WBCnstr00004214
WBCnstr00024061
Construct_productWBCnstr00024061
Microarray_results (32)
Expression_clusterWBPaper00029359_1280
WBPaper00029359_1310
WBPaper00029359_1364
WBPaper00029359_1444
WBPaper00029359_1504
WBPaper00029359_1578
WBPaper00029359_1604
WBPaper00032031:DConiospora_upregulated_cDNA_24h
WBPaper00033070:Elbe_downregulated
WBPaper00035269:cde-1_regulated
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_embryo_enriched
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:bodywall-muscle_larva_enriched
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038168:lin-15B(n744)_upregulated
WBPaper00040221:DAF-12_target_ALF4
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:oscillating_dev_expression
WBPaper00045257:bar-1(ga80)_upregulated
WBPaper00045417:128Q-huntingtin_upreglated
WBPaper00045521:Gender_Neutral
WBPaper00046421:cdc-48.2(tm659)_upregulated
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00048611:MnCl2_downregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049368:daf-2(e1370)_downregulated
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
WBPaper00050412:cco-1(RNAi)_downregulated_N2
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050522:mafr-1(tm6082)_downregulated
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:intestine_expressed
WBPaper00051137:Orsay-virus_upregulated_N2
WBPaper00051404:alg-1(gk214)_upregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053295:lin-22(icb38)_downregulated
WBPaper00053302:stavudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
WBPaper00053321:PGCs_enriched_NuGen
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00055565:AVK_enriched
WBPaper00055648:germline_expressed
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056139:gut-microbiota_downregulated
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056290:hsp-6(mg585)_downregulated
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056809:smn-1(ok355)_upregulated
WBPaper00056826:SGP_biased
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00057154:HeatShock_upregulated_miRNA-target
WBPaper00058598:sin-3(tm1276)_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059440:LAG-1_activated_48hr-auxin
WBPaper00059471:EGL-43_interacting
WBPaper00059763:neuron_expressed
WBPaper00060445:ikb-1(nr2027)_upregulated_L4
WBPaper00060445:nfki-1(cer1)_upregulated_L4
WBPaper00060661:sensory-neuron_depleted
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00061203:sin-3(tm1276)_downregulated
WBPaper00061319:pnp-1(jy90)_upregulated
WBPaper00061340:AIZ
WBPaper00061340:RIA
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061527:lst-4_22151-F46F11.6_12556
WBPaper00062056:lin-15B(n744)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062345:bortezomib_4h_upregulated_N2
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064107:lin-35(n745)_upregulated
WBPaper00064532:pals-22(jy3)_upregulated
WBPaper00064532:pals-25(icb98)_upregulated
WBPaper00064716:paraquat_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065149:lin-52(n771)_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065841:83_0
WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
WBPaper00065984:pals-17(syb3980)_upregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
cgc4489_group_9
WBPaper00025032:cluster_1
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00030985:Enterococcus_faecalis_upregulated
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00032948:StarveUp1
WBPaper00034739:N2moreDR1350
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00036123:Atrazine_regulated
WBPaper00036130:mir-243_down_regulated
WBPaper00038427:lin-54_embryo_changed
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00046548:dafachronic-acid_downregulated
WBPaper00047070:DAF-16-dependent_UV_response
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00053236:Starvation_regulated_GR1307
[cgc5767]:cluster_1
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MD_pd(41_min)
[cgc5767]:expression_class_MD_pd(53_min)
[cgc5767]:expression_class_SM
[cgc5767]:expression_class_SMD
Interaction (24)
Map_infoPositivePositive_cloneZK177Inferred_automaticallyFrom sequence, transcript, pseudogene data
Interpolated_map_positionII-1.22624
ReferenceWBPaper00038491
WBPaper00055090
WBPaper00065885
MethodGene