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WormBase Tree Display for Gene: WBGene00006868

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Name Class

WBGene00006868SMapS_parentSequenceM03A1
IdentityVersion1
NameCGC_namevab-1Person_evidenceWBPerson261
Sequence_nameM03A1.1
Molecular_nameM03A1.1
M03A1.1.1
CE25060
Other_nameCELE_M03A1.1Accession_evidenceNDBBX284602
Public_namevab-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classvab
Reference_alleleWBVar00142901
Allele (418)
Legacy_informatione2 : notched head variable dystrophy of ventral cephalic region especially in L1; penetrance < 70%. ES3/0 ME3. NA8 (e1063 : penetrance 35%; e2027spo : penetrance > 90%).
See also e2, e116, e118, e200, e699, e721, e1063, e2027
[C.elegansII] e2 : notched head, variable dystrophy of ventral cephalic region, especially in L1; penetrance < 70%. ES3/0 ME3. OA>10: e1063 (penetrance 35%), e2027spo (penetrance > 90%), e699 etc. [Brenner 1974; Lewis and Hodgkin 1979; CB; CZ]
Strain (24)
RNASeq_FPKM (74)
GO_annotation00035992
00035993
00035994
00035995
00035996
00035997
00035998
00035999
00036000
00036001
00036002
00036003
00036004
00036005
00036006
00036007
00036008
00036009
00036010
00036011
00036012
00036013
00036014
00036015
00036016
00036017
00036018
00036019
00036020
00036021
00036022
00036023
00036024
00036025
00036026
00114948
00114949
00114950
Ortholog (113)
Paralog (69)
Structured_descriptionConcise_descriptionvab-1 encodes an ephrin receptor; during development, vab-1 activity is required for neural and epithelial morphogenesis as well as for proper axon targeting and neuronal cell migration; in addition, VAB-1 functions as a major sperm protein receptor in a sperm-sensing control mechanism that regulates oocyte meiotic maturation; VAB-1::GFP reporters are expressed in neuronal cells and in oocytes and sheath cells of the proximal gonad.Paper_evidenceWBPaper00003020
WBPaper00003843
WBPaper00005670
WBPaper00027013
Curator_confirmedWBPerson1843
Date_last_updated28 Feb 2007 00:00:00
Automated_descriptionEnables ephrin receptor activity and protein domain specific binding activity. Involved in several processes, including cell development; embryonic morphogenesis; and regulation of axon guidance. Located in axon and plasma membrane. Expressed in several structures, including hypodermal cell; neuroblasts; neurons; oocyte; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; aortic dissection; cataract 6 multiple types; and gastrointestinal system cancer (multiple). Is an ortholog of several human genes including EPHB1 (EPH receptor B1); EPHB2 (EPH receptor B2); and EPHB3 (EPH receptor B3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (14)
Molecular_infoCorresponding_CDSM03A1.1
Corresponding_CDS_historyM03A1.1b:wp274
Corresponding_transcriptM03A1.1.1
Other_sequence (11)
Associated_feature (54)
Experimental_infoRNAi_result (27)
Expr_pattern (16)
Drives_constructWBCnstr00000707
WBCnstr00006419
WBCnstr00009616
WBCnstr00018076
WBCnstr00034120
WBCnstr00042438
Construct_product (15)
Antibody (5)
Microarray_results (28)
Expression_cluster (158)
Interaction (248)
Anatomy_functionWBbtf0217
WBbtf0220
WBProcessWBbiopr:00000001
WBbiopr:00000068
WBbiopr:00000120
Map_infoMapIIPosition-3.85469Error0.013028
Well_ordered
PositiveInside_rearrmDf14
mDf15
Positive_cloneM03A1Person_evidenceWBPerson105
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point266
Multi_point48
881
882
1880
4031
4032
Pos_neg_data (12)
Reference (154)
MethodGene