WormBase Tree Display for Gene: WBGene00002229
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| WBGene00002229 | SMap | S_parent | Sequence | Y43F4B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | klp-19 | Person_evidence | WBPerson589 | |||||
| Sequence_name | Y43F4B.6 | ||||||||
| Molecular_name | Y43F4B.6 | ||||||||
| Y43F4B.6.1 | |||||||||
| CE16631 | |||||||||
| Other_name | CELE_Y43F4B.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | klp-19 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | klp | ||||||||
| Allele (59) | |||||||||
| Strain | WBStrain00034457 | ||||||||
| WBStrain00037513 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00035665 | ||||||||
| 00035666 | |||||||||
| 00035667 | |||||||||
| 00035668 | |||||||||
| 00035669 | |||||||||
| 00035670 | |||||||||
| 00035671 | |||||||||
| 00035672 | |||||||||
| 00035673 | |||||||||
| 00035674 | |||||||||
| 00035675 | |||||||||
| 00035676 | |||||||||
| 00035677 | |||||||||
| 00035678 | |||||||||
| 00035679 | |||||||||
| 00035680 | |||||||||
| 00035681 | |||||||||
| 00035682 | |||||||||
| 00035683 | |||||||||
| 00035684 | |||||||||
| 00035685 | |||||||||
| 00035686 | |||||||||
| 00035687 | |||||||||
| 00035688 | |||||||||
| 00035689 | |||||||||
| 00110234 | |||||||||
| 00110235 | |||||||||
| 00110236 | |||||||||
| 00110237 | |||||||||
| Ortholog (41) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | klp-19 encodes a plus-end-directed microtubule motor protein that is most closely related to motors of the kinesin-4 family; KLP-19 activity is essential for embryonic and larval development and is required for generating a force that aligns sister chromatid kinetochores directly opposite the spindle poles thus ensuring proper holocentric chromosome segregation; KLP-19 expression is detected in embryos and in the gonad, where it is most strongly expressed in distal mitotic nuclei and in late meiotic prophase nucleoplasm; during meiosis and mitosis, KLP-19 expression is dynamic and is detected in the nucleoplasm, the spindle body, in association with condensed chromosomes (particularly between homologous chromosomes), and in the spindle interzone. | Paper_evidence | WBPaper00024405 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Jan 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in meiotic chromosome condensation and meiotic spindle midzone assembly. Located in condensed nuclear chromosome; nucleoplasm; and spindle. Expressed in germ line. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Is an ortholog of human KIF4A (kinesin family member 4A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112040 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13339) | ||||
| Molecular_info | Corresponding_CDS | Y43F4B.6 | |||||||
| Corresponding_transcript | Y43F4B.6.1 | ||||||||
| Other_sequence (18) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (24) | ||||||||
| Expr_pattern | Expr3116 | ||||||||
| Expr16333 | |||||||||
| Expr1011369 | |||||||||
| Expr1031306 | |||||||||
| Expr1159961 | |||||||||
| Expr2012962 | |||||||||
| Expr2031194 | |||||||||
| Drives_construct | WBCnstr00042912 | ||||||||
| Antibody | WBAntibody00000778 | ||||||||
| WBAntibody00002846 | |||||||||
| WBAntibody00002919 | |||||||||
| WBAntibody00002967 | |||||||||
| WBAntibody00002973 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (34) | |||||||||
| Map_info | Map | III | Position | 21.21 | Error | 0.000801 | |||
| Positive | Positive_clone | Y43F4B | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5197 | |||||||
| 4549 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Sequence connection from [Siddiqui SS], 02/06/11 krb. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
