WormBase Tree Display for Gene: WBGene00006783
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| WBGene00006783 | SMap | S_parent | Sequence | T20G5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-47 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T20G5.6 | ||||||||
| Molecular_name | T20G5.6 | ||||||||
| T20G5.6.1 | |||||||||
| CE25119 | |||||||||
| Other_name | CELE_T20G5.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | unc-47 | ||||||||
| DB_info | Database | AceView | gene | 3L274 | |||||
| WormQTL | gene | WBGene00006783 | |||||||
| WormFlux | gene | WBGene00006783 | |||||||
| NDB | locus_tag | CELE_T20G5.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006783|UniProtKB=P34579 | |||||||
| family | PTHR48017 | ||||||||
| NCBI | gene | 176431 | |||||||
| RefSeq | protein | NM_066854.7 | |||||||
| SwissProt | UniProtAcc | P34579 | |||||||
| TREEFAM | TREEFAM_ID | TF312818 | |||||||
| UniProt_GCRP | UniProtAcc | P34579 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143102 | ||||||||
| Allele (45) | |||||||||
| Legacy_information | e307 : very poor backing good slow forward movement slight shrinker (contracts both dorsally and ventrally when prodded) small; abnormal staining with anti-GABA antibodies. ES3 ME2. NA3 (e542 e707). | ||||||||
| [C.elegansII] e307 : very poor backing, good slow forward movement; slight shrinker (contracts both dorsally and ventrally when prodded); small; abnormal staining with anti-GABA antibodies (accumulates GABA).ES3 ME2. OA2: e542, e707. [Brenner 1974; McIntire et al. 1993; EG; MT] | |||||||||
| [Jorgensen EM] Predicted gene T20G5.6, 486 aa, 10 predicted TM domains, vesicular GABA transporter, UNC-47:GFP colocalizes with synaptic vesicles. e307 alters acceptor G at exon six, n2476 is 238bp deletion, n2409 is G462R | |||||||||
| Strain (30) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | unc-47 encodes a novel transmembrane vesicular GABA transporter; UNC-47 and UNC-46, a predicted novel transmembrane protein, are required in GABAergic neurons for all GABA neurotransmission, specifically for loading of GABA into synaptic vesicles, where UNC-47 is localized; UNC-47 is required for the localization of UNC-46, and when overexpressed can rescue unc-46 mutant animals; UNC-47 expression in type D neurons is transcriptionally regulated by the UNC-30 homeodomain protein. | Paper_evidence | WBPaper00002911 | |||||
| WBPaper00003619 | |||||||||
| WBPaper00017004 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable glycine transmembrane transporter activity. Predicted to be involved in gamma-aminobutyric acid transport; glycine transport; and neurotransmitter loading into synaptic vesicle. Located in synaptic vesicle. Expressed in neurons. Used to study alcohol use disorder. Is an ortholog of human SLC32A1 (solute carrier family 32 member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045914 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jun 2019 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000701 | ||||||||
| Molecular_info | Corresponding_CDS | T20G5.6 | |||||||
| Corresponding_transcript | T20G5.6.1 | ||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf651444 | ||||||||
| WBsf667371 | |||||||||
| WBsf993928 | |||||||||
| WBsf227418 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (100) | |||||||||
| Construct_product | WBCnstr00007137 | ||||||||
| WBCnstr00010287 | |||||||||
| WBCnstr00017691 | |||||||||
| WBCnstr00034154 | |||||||||
| WBCnstr00038182 | |||||||||
| WBCnstr00038792 | |||||||||
| Antibody | WBAntibody00001995 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (135) | |||||||||
| Interaction (20) | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | III | Position | 2.00204 | Error | 0.005419 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | E03F9 | |||||||
| T20G5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 55 | |||||||
| 62 | |||||||||
| 67 | |||||||||
| 74 | |||||||||
| 3248 | |||||||||
| Multi_point (22) | |||||||||
| Pos_neg_data | 651 | ||||||||
| Reference (140) | |||||||||
| Remark | Data extracted from McIntire et al. (1997) | ||||||||
| Method | Gene |
