WormBase Tree Display for Gene: WBGene00000035
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| WBGene00000035 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ace-1 | Person_evidence | WBPerson1417 | |||||
| WBPerson36909 | |||||||||
| WBPerson7188 | |||||||||
| Sequence_name | W09B12.1 | ||||||||
| Molecular_name | W09B12.1 | ||||||||
| W09B12.1.1 | |||||||||
| CE07569 | |||||||||
| Other_name | ACE1 | Accession_evidence | EMBL | X75331 | |||||
| cest-23 | |||||||||
| CELE_W09B12.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | ace-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 20 May 2019 14:10:26 | WBPerson1983 | Name_change | CGC_name | ace-1 | ||||
| Other_name | cest-23 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ace | ||||||||
| Reference_allele | WBVar00095133 | ||||||||
| Allele (103) | |||||||||
| Legacy_information | p1000 : class A acetylcholinesterase reduced 100%; no behavioral phenotype alone (ES1 ME3) but ace-2;ace-1 is uncoordinated (hypercontracted) and ace-2;ace-3;ace-1 is L1 lethal. NA7. | ||||||||
| See also e1572 | |||||||||
| [C.elegansII] p1000 : class A acetylcholinesterase reduced 100%; no behavioral phenotype alone (ES1 ME3) but ace-2;ace-1 is uncoordinated (hypercontracted) and ace-2;ace-3;ace-1 is L1 lethal. Mosaic focus in muscle. OA6: e1572 etc.Cloned: sequence predicts 609 aa, 37% identity with Torpedo acetylcholinesterase. p1000 is W99op. [Herman and Kari 1985; Arpagaus et al. 1994; FF] | |||||||||
| Strain | WBStrain00024338 | ||||||||
| WBStrain00030800 | |||||||||
| WBStrain00035826 | |||||||||
| WBStrain00040622 | |||||||||
| WBStrain00007852 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (38) | |||||||||
| Structured_description | Concise_description | ace-1 encodes a class A acetylcholinesterase that functions redundantly with ACE-2 with respect to total class A acetylcholinesterase activity, and that genetically interacts with ace-2 and ace-3; ace-1 is expressed in the body wall muscle, sphincter muscle, head neurons, a few pharyngeal muscle cells, and the diagonal and spicule muscles of the male. | Paper_evidence | WBPaper00000514 | |||||
| WBPaper00000795 | |||||||||
| WBPaper00002110 | |||||||||
| WBPaper00003620 | |||||||||
| WBPaper00004251 | |||||||||
| WBPaper00004932 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson480 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables acetylcholinesterase activity and identical protein binding activity. Involved in acetylcholine catabolic process and regulation of locomotion. Located in extracellular space. Expressed in CEP; M cell; OLL; body wall musculature; and non-striated muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); and autoimmune disease (multiple). Is an ortholog of human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (19) | ||||||||
| Molecular_info | Corresponding_CDS | W09B12.1 | |||||||
| Corresponding_transcript | W09B12.1.1 | ||||||||
| Other_sequence (25) | |||||||||
| Associated_feature (7) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00075453 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00089181 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019735 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030254 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055010 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1222 | ||||||||
| Expr1015117 | |||||||||
| Expr1030015 | |||||||||
| Expr1158543 | |||||||||
| Expr2009142 | |||||||||
| Expr2027379 | |||||||||
| Drives_construct | WBCnstr00008263 | ||||||||
| WBCnstr00008264 | |||||||||
| WBCnstr00008265 | |||||||||
| WBCnstr00008267 | |||||||||
| WBCnstr00008268 | |||||||||
| WBCnstr00010160 | |||||||||
| WBCnstr00018564 | |||||||||
| WBCnstr00037779 | |||||||||
| Construct_product | WBCnstr00008263 | ||||||||
| WBCnstr00008264 | |||||||||
| WBCnstr00008265 | |||||||||
| WBCnstr00008266 | |||||||||
| WBCnstr00008268 | |||||||||
| WBCnstr00010160 | |||||||||
| WBCnstr00037779 | |||||||||
| Regulate_expr_cluster | WBPaper00044452:ace_1_ace-2_downregulated | ||||||||
| WBPaper00044452:ace_1_ace-2_upregulated | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction | WBInteraction000004512 | ||||||||
| WBInteraction000004513 | |||||||||
| WBInteraction000004514 | |||||||||
| WBInteraction000005664 | |||||||||
| WBInteraction000008703 | |||||||||
| WBInteraction000008830 | |||||||||
| WBInteraction000009007 | |||||||||
| WBInteraction000009010 | |||||||||
| WBInteraction000034060 | |||||||||
| WBInteraction000034468 | |||||||||
| WBInteraction000041787 | |||||||||
| WBInteraction000042527 | |||||||||
| WBInteraction000042528 | |||||||||
| WBInteraction000043742 | |||||||||
| WBInteraction000044441 | |||||||||
| WBInteraction000047431 | |||||||||
| WBInteraction000049417 | |||||||||
| WBInteraction000126055 | |||||||||
| WBInteraction000126056 | |||||||||
| WBInteraction000126947 | |||||||||
| WBInteraction000160408 | |||||||||
| WBInteraction000160409 | |||||||||
| WBInteraction000160410 | |||||||||
| WBInteraction000160411 | |||||||||
| WBInteraction000166989 | |||||||||
| WBInteraction000167332 | |||||||||
| WBInteraction000167335 | |||||||||
| WBInteraction000183696 | |||||||||
| WBInteraction000253157 | |||||||||
| WBInteraction000253196 | |||||||||
| WBInteraction000287244 | |||||||||
| WBInteraction000354423 | |||||||||
| WBInteraction000357470 | |||||||||
| WBInteraction000500341 | |||||||||
| WBInteraction000500342 | |||||||||
| WBInteraction000500343 | |||||||||
| WBInteraction000500344 | |||||||||
| WBInteraction000500356 | |||||||||
| WBInteraction000502003 | |||||||||
| WBInteraction000502396 | |||||||||
| WBInteraction000518032 | |||||||||
| WBInteraction000518041 | |||||||||
| WBInteraction000518043 | |||||||||
| WBInteraction000518551 | |||||||||
| WBInteraction000519130 | |||||||||
| WBInteraction000519132 | |||||||||
| WBInteraction000555252 | |||||||||
| WBInteraction000562638 | |||||||||
| Anatomy_function | WBbtf0036 | ||||||||
| WBbtf0037 | |||||||||
| WBbtf0038 | |||||||||
| WBbtf1031 | |||||||||
| WBbtf1032 | |||||||||
| WBbtf1033 | |||||||||
| Map_info | Map | X | Position | 23.9071 | Error | 0.00351 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | W09B12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 3682 | |||||||
| Multi_point | 195 | ||||||||
| 196 | |||||||||
| 4958 | |||||||||
| Pos_neg_data (15) | |||||||||
| Landmark_gene | |||||||||
| Reference (92) | |||||||||
| Method | Gene |
