unc-55 encodes a nuclear receptor that is most closely related to Drosophila Seven-up and the vertebrate COUP (chicken ovalbumin upstream promoter) transcription factors; unc-55 activity is required for the VD motor neurons to adopt their normal synaptic pattern; unc-55 is expressed in a number of neurons, including the VD motor neurons.
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in cell fate specification and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in motor neurons; somatic nervous system; and spicule muscle. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5 and Bosch-Boonstra-Schaaf optic atrophy syndrome. Is an ortholog of human NR2F1 (nuclear receptor subfamily 2 group F member 1) and NR2F2 (nuclear receptor subfamily 2 group F member 2).