| WBGene00006801 | SMap | S_parent | Sequence | CHROMOSOME_V |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | unc-68 | Person_evidence | WBPerson261 |
| | | Sequence_name | K11C4.5 |
| | | Molecular_name (48) |
| | | Other_name | ryr-1 |
| | | | kra-1 |
| | | | CELE_K11C4.5 | Accession_evidence | NDB | BX284605 |
| | | Public_name | unc-68 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 07 Nov 2007 17:12:59 | WBPerson2970 | Event | Acquires_merge | WBGene00021962 |
| | | Acquires_merge | WBGene00021962 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143286 |
| | Allele (351) |
| | Legacy_information | See also e2313 |
| | | [Kagawa H] pka ryr-1, for ryanodine receptor. 46 exons, encodes 5071 aa predicted protein. e540 (Unc-68) is intron 21 splice acceptor mutation, probable null. Weak allele kh30 (pka kra-1) exhibits ketamine-dependent convulsions followed by paralysis, mutation is S1444N change at putative PKC phosphorylation site. |
| | | [C.elegansII] e540 : weak kinker, slow, thin; slight shrinker; head region but not body resistant to 1 mM levamisole, ouabain. ES3. ME2. OA>15: x14, x24, e932, e2313,s92spo, r1162 (presumed null, deletes all TM domains) etc.(all resemble e540). Cloned: 30 kb gene, 43 exons, encodes 4902 aa ryanodine receptor (43% identity to mammalian cardiac RYR). [Brenner 1974; Lewis et al. 1980; HK; TR] |
| | | [C.elegansII] kh30 : semidominant convulsive behavior in 30mM ketamine or other NMDA antagonists; recessive cs Unc; variable motility; weakly resistant to cholinergic agonists, ouabain;normal muscle morphology. [HK] |
| | Complementation_data | [Kagawa H] fails to complement kh30 (pka kra-1) |
| | Strain (21) |
| | RNASeq_FPKM | WBls:0000002 (84) |
| | | WBls:0000003 (11) |
| | | WBls:0000004 (47) |
| | | WBls:0000006 | 0.388415 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000006.Hermaphrodite.WBbt:0007833.SRP042619.SRX559705 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000006.Hermaphrodite.WBbt:0007833.SRP042619.SRX559706 |
| | | WBls:0000007 (11) |
| | | WBls:0000008 | 0.206047 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX085219 |
| | | | 0.54362 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX145480 |
| | | | 0.680714 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX085220 |
| | | WBls:0000010 (15) |
| | | WBls:0000013 (11) |
| | | WBls:0000014 (19) |
| | | WBls:0000015 (24) |
| | | WBls:0000017 | 0.580561 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343252 |
| | | | 0.933093 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004015.SRP029448.SRX343304 |
| | | | 0.96855 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004015.SRP029448.SRX343305 |
| | | | 11.181 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0003810.SRP029448.SRX343324 |
| | | | 1e-10 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343253 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343254 |
| | | | 23.0371 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004458.SRP029448.SRX343278 |
| | | | 23.7416 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0008115.SRP029448.SRX343342 |
| | | | 58.0197 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004458.SRP029448.SRX343277 |
| | | | 7.43954 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0003810.SRP029448.SRX343325 |
| | | WBls:0000020 (16) |
| | | WBls:0000021 (20) |
| | | WBls:0000023 | 0.0227717 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000023.Hermaphrodite.WBbt:0007833.SRP015688.SRX185639 |
| | | WBls:0000024 (71) |
| | | WBls:0000027 (15) |
| | | WBls:0000031 | 24.0141 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103275 |
| | | | 26.106 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX008139 |
| | | | 26.6439 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103276 |
| | | | 27.4479 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103273 |
| | | | 27.8841 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103274 |
| | | | 6.66373 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103277 |
| | | | 8.31677 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX047470 |
| | | WBls:0000032 | 14.0844 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103985 |
| | | | 14.5847 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103984 |
| | | | 15.1458 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103983 |
| | | | 3.0968 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019178 |
| | | | 4.34161 | From_analysis | RNASeq.elegans.WBls:0000032.control_mean |
| | | | | | RNASeq.elegans.WBls:0000032.control_median |
| | | | 5.58641 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019179 |
| | | | 6.76607 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX008138 |
| | | WBls:0000035 (26) |
| | | WBls:0000038 (77) |
| | | WBls:0000041 (30) |
| | | WBls:0000052 | 0.24923 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX008140 |
| | | | 10.4817 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103271 |
| | | | 10.6626 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103278 |
| | | | 10.6998 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103279 |
| | | | 11.0021 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103281 |
| | | | 11.8666 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103272 |
| | | | 12.8581 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103270 |
| | | | 12.8862 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103269 |
| | | | 6.33392 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX037199 |
| | | | 9.83745 | From_analysis | RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103280 |
| | | WBls:0000063 (103) |
| | | WBls:0000064 (14) |
| | | WBls:0000065 (16) |
| | | WBls:0000068 | 2.86884 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265361 |
| | | | 3.04439 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265360 |
| | | | 3.30462 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265364 |
| | | | 3.51223 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265363 |
| | | | 3.63319 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265362 |
| | | | 3.74369 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265365 |
| | | WBls:0000131 | 0.0521939 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343220 |
| | | | 0.162684 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343229 |
| | | | 0.398066 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343223 |
| | | | 0.518802 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343228 |
| | | | 0.88283 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006771.SRP029448.SRX343226 |
| | | | 1e-10 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343227 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006771.SRP029448.SRX343225 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343221 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343222 |
| | | WBls:0000141 | 0.118286 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000141.Hermaphrodite.WBbt:0007833.SRP029448.SRX343161 |
| | | WBls:0000151 | 0.0931428 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0004804.SRP029448.SRX343230 |
| | | | 0.166716 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0007833.SRP029448.SRX343162 |
| | | | 0.239896 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0004458.SRP029448.SRX343257 |
| | | | 0.45844 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0008115.SRP029448.SRX343326 |
| | | | 1e-10 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0003810.SRP029448.SRX343308 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0004015.SRP029448.SRX343280 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0004015.SRP029448.SRX343281 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0004015.SRP029448.SRX343282 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0004458.SRP029448.SRX343255 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0004458.SRP029448.SRX343256 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0004804.SRP029448.SRX343231 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0004804.SRP029448.SRX343232 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0008115.SRP029448.SRX343327 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000151.Hermaphrodite.WBbt:0008115.SRP029448.SRX343328 |
| | | WBls:0000171 | 0.0235635 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000171.Hermaphrodite.WBbt:0004804.SRP029448.SRX343234 |
| | | | 0.0287547 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000171.Hermaphrodite.WBbt:0004804.SRP029448.SRX343233 |
| | | | 0.0412998 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000171.Hermaphrodite.WBbt:0004458.SRP029448.SRX343259 |
| | | | 0.337595 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000171.Hermaphrodite.WBbt:0007833.SRP029448.SRX343163 |
| | | | 1e-10 | From_analysis (11) |
| | | WBls:0000181 | 0.271491 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000181.Hermaphrodite.WBbt:0007833.SRP029448.SRX343164 |
| | | WBls:0000191 | 0.499068 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000191.Hermaphrodite.WBbt:0007833.SRP029448.SRX343165 |
| | | WBls:0000201 | 0.17066 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0004804.SRP029448.SRX343237 |
| | | | 1e-10 | From_analysis (11) |
| | | WBls:0000221 | 0.44113 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343265 |
| | | | 0.561884 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004015.SRP029448.SRX343290 |
| | | | 0.565625 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0008115.SRP029448.SRX343333 |
| | | | 1e-10 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0003810.SRP029448.SRX343314 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0003810.SRP029448.SRX343315 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004015.SRP029448.SRX343291 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343264 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343266 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004804.SRP029448.SRX343241 |
| | | | 2.77577 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0008115.SRP029448.SRX343334 |
| | | WBls:0000231 | 0.537456 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000231.Hermaphrodite.WBbt:0007833.SRP029448.SRX343167 |
| | | WBls:0000251 | 0.48287 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0007833.SRP029448.SRX343168 |
| | | | 0.901798 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004015.SRP029448.SRX343292 |
| | | | 1e-10 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0003810.SRP029448.SRX343317 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004458.SRP029448.SRX343268 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343242 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343243 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343244 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343335 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343337 |
| | | | 3.60874 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343336 |
| | | WBls:0000261 | 0.402651 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000261.Hermaphrodite.WBbt:0007833.SRP029448.SRX343169 |
| | | WBls:0000281 | 0.494848 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000281.Hermaphrodite.WBbt:0007833.SRP029448.SRX343170 |
| | | WBls:0000291 | 0.0724898 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0004804.SRP029448.SRX343245 |
| | | | 0.0811853 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0004015.SRP029448.SRX343294 |
| | | | 0.44291 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0007833.SRP029448.SRX343171 |
| | | | 0.685968 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0004458.SRP029448.SRX343271 |
| | | | 0.914517 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0004804.SRP029448.SRX343247 |
| | | | 1.00523 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0003810.SRP029448.SRX343319 |
| | | | 1e-10 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0003810.SRP029448.SRX343318 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0004015.SRP029448.SRX343295 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0004015.SRP029448.SRX343296 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0004458.SRP029448.SRX343272 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0004804.SRP029448.SRX343246 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0008115.SRP029448.SRX343338 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000291.Hermaphrodite.WBbt:0008115.SRP029448.SRX343339 |
| | | WBls:0000301 | 0.451583 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000301.Hermaphrodite.WBbt:0007833.SRP029448.SRX343172 |
| | | WBls:0000311 | 0.445123 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000311.Hermaphrodite.WBbt:0007833.SRP029448.SRX343173 |
| | | WBls:0000321 | 0.829144 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000321.Hermaphrodite.WBbt:0007833.SRP029448.SRX343174 |
| | | WBls:0000331 | 0.235024 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000331.Hermaphrodite.WBbt:0007833.SRP029448.SRX343176 |
| | | | 0.471523 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000331.Hermaphrodite.WBbt:0007833.SRP029448.SRX343175 |
| | | WBls:0000351 | 0.43876 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000351.Hermaphrodite.WBbt:0007833.SRP029448.SRX343179 |
| | | | 0.827774 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000351.Hermaphrodite.WBbt:0007833.SRP029448.SRX343178 |
| | | WBls:0000361 | 0.871788 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000361.Hermaphrodite.WBbt:0007833.SRP029448.SRX343180 |
| | | WBls:0000381 | 0.791605 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004458.SRP029448.SRX343274 |
| | | | 1e-10 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0003810.SRP029448.SRX343320 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004015.SRP029448.SRX343297 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004015.SRP029448.SRX343299 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004458.SRP029448.SRX343275 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343248 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343249 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343250 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0008115.SRP029448.SRX343340 |
| | | WBls:0000391 | 1.02156 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000391.Hermaphrodite.WBbt:0007833.SRP029448.SRX343181 |
| | | WBls:0000401 | 2.2558 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000401.Hermaphrodite.WBbt:0007833.SRP029448.SRX343182 |
| | | WBls:0000421 | 4.54919 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000421.Hermaphrodite.WBbt:0007833.SRP029448.SRX343184 |
| | | WBls:0000431 | 2.18845 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000431.Hermaphrodite.WBbt:0007833.SRP029448.SRX343185 |
| | | WBls:0000451 | 7.49855 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000451.Hermaphrodite.WBbt:0007833.SRP029448.SRX343186 |
| | | WBls:0000461 | 7.87466 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000461.Hermaphrodite.WBbt:0007833.SRP029448.SRX343187 |
| | | WBls:0000471 | 0.689213 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004804.SRP029448.SRX343251 |
| | | | 10.9501 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0007833.SRP029448.SRX343189 |
| | | | 1.09878 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343302 |
| | | | 13.9442 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0008115.SRP029448.SRX343341 |
| | | | 1e-10 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343300 |
| | | | | | RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343301 |
| | | | 2.44369 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004458.SRP029448.SRX343276 |
| | | WBls:0000491 | 7.27137 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000491.Hermaphrodite.WBbt:0007833.SRP029448.SRX343191 |
| | | WBls:0000501 | 13.5113 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000501.Hermaphrodite.WBbt:0007833.SRP029448.SRX343192 |
| | | WBls:0000511 | 12.0419 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000511.Hermaphrodite.WBbt:0007833.SRP029448.SRX343194 |
| | | WBls:0000521 | 8.8815 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000521.Hermaphrodite.WBbt:0007833.SRP029448.SRX343195 |
| | | WBls:0000531 | 11.0408 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000531.Hermaphrodite.WBbt:0007833.SRP029448.SRX343197 |
| | | | 14.9874 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000531.Hermaphrodite.WBbt:0007833.SRP029448.SRX343196 |
| | | WBls:0000541 | 10.6704 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000541.Hermaphrodite.WBbt:0007833.SRP029448.SRX343198 |
| | | | 7.93245 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000541.Hermaphrodite.WBbt:0007833.SRP029448.SRX343199 |
| | | WBls:0000551 | 8.81016 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000551.Hermaphrodite.WBbt:0007833.SRP029448.SRX343200 |
| | | WBls:0000561 | 5.52264 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000561.Hermaphrodite.WBbt:0007833.SRP029448.SRX343201 |
| | | WBls:0000581 | 7.37571 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000581.Hermaphrodite.WBbt:0007833.SRP029448.SRX343202 |
| | | WBls:0000621 | 4.73144 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000621.Hermaphrodite.WBbt:0007833.SRP029448.SRX343203 |
| | | WBls:0000674 | 2.26575 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265366 |
| | | | 2.64724 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265370 |
| | | | 2.69202 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265369 |
| | | | 2.74802 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265371 |
| | | | 3.07078 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265368 |
| | | | 3.23136 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265367 |
| | | WBls:0000676 | 4.30868 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265374 |
| | | | 5.20727 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265375 |
| | | | 6.25622 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265372 |
| | | | 6.47014 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265373 |
| | | WBls:0000694 | 5.40497 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000694.Hermaphrodite.WBbt:0007833.SRP029448.SRX343205 |
| | | WBls:0000695 | 6.26683 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000695.Hermaphrodite.WBbt:0007833.SRP029448.SRX343206 |
| | | WBls:0000696 | 9.62141 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000696.Hermaphrodite.WBbt:0007833.SRP029448.SRX343207 |
| | | WBls:0000697 | 7.72984 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000697.Hermaphrodite.WBbt:0007833.SRP029448.SRX343208 |
| | | WBls:0000699 | 6.43194 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000699.Hermaphrodite.WBbt:0007833.SRP029448.SRX343210 |
| | | WBls:0000700 | 2.06918 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000700.Hermaphrodite.WBbt:0007833.SRP029448.SRX343211 |
| | | WBls:0000701 | 6.45194 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000701.Hermaphrodite.WBbt:0007833.SRP029448.SRX343212 |
| | | WBls:0000702 | 3.0002 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000702.Hermaphrodite.WBbt:0007833.SRP029448.SRX343213 |
| | | WBls:0000703 | 5.57799 | From_analysis | RNASeq.elegans.WBStrain00000001.WBls:0000703.Hermaphrodite.WBbt:0007833.SRP029448.SRX343214 |
| | GO_annotation (28) |
| | Ortholog (67) |
| | Paralog | WBGene00002173 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | unc-68 encodes a ryanodine receptor ortholog that is expressed in body-wall muscle cells and is required for normal body tension and locomotion; unc-68 mutants are flaccid, sluggish, and resistant to ryanodine, but have normal muscle ultrastructure; UNC-68 is dispensable for excitation-contraction coupling itself, but may amplify its calcium signals; the unc-68/kra-1(kh30) mutation is an S1444N substitution at a putative protein kinase C phosphorylation site; UNC-68 reduced unc-103(sy557)-induced spicule protraction by one half; unc-68 is orthologous to the human genes RYR1 (OMIM:180901, mutated in malignant hyperthermia and central core disease), RYR2 (OMIM:180902, mutated in stress-induced polymorphic ventricular tachycardia), and RYR3 (OMIM:180903). | Paper_evidence (4) |
| | | | | Curator_confirmed | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable calcium ion binding activity and ryanodine-sensitive calcium-release channel activity. Involved in locomotion; positive regulation of programmed cell death; and protein localization to organelle. Located in I band and sarcoplasmic reticulum. Expressed in body wall musculature; intestine; neurons; and non-striated muscle. Used to study congenital myopathy 1A and malignant hyperthermia. Human ortholog(s) of this gene implicated in several diseases, including catecholaminergic polymorphic ventricular tachycardia 1; intracranial vasospasm; and muscle tissue disease (multiple). Is an ortholog of human RYR1 (ryanodine receptor 1); RYR2 (ryanodine receptor 2); and RYR3 (ryanodine receptor 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:3529 | Homo sapiens | Paper_evidence | WBPaper00059411 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 08 Jun 2021 00:00:00 |
| | | DOID:8545 | Homo sapiens | Paper_evidence | WBPaper00059411 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 08 Jun 2021 00:00:00 |
| | Potential_model (12) |
| Modifies_disease | DOID:11723 |
| Modifies_disease_in_annotation | WBDOannot00000746 |
| Models_disease_asserted (14) |
| Molecular_info | Corresponding_CDS (16) |
| | Corresponding_CDS_history | K11C4.5:wp166 |
| | | K11C4.5:wp184 |
| | | K11C4.5a:wp261 |
| | | K11C4.5b:wp236 |
| | | K11C4.5b:wp261 |
| | | K11C4.5c:wp261 |
| | | K11C4.5d:wp261 |
| | Corresponding_transcript (16) |
| | Other_sequence (63) |
| | Associated_feature (24) |
| Experimental_info | RNAi_result (20) |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00006689 |
| | | WBCnstr00010174 |
| | | WBCnstr00010354 |
| | | WBCnstr00010749 |
| | | WBCnstr00015983 |
| | | WBCnstr00015984 |
| | | WBCnstr00039937 |
| | | WBCnstr00039938 |
| | Construct_product | WBCnstr00000351 |
| | | WBCnstr00000352 |
| | | WBCnstr00006689 |
| | | WBCnstr00010354 |
| | | WBCnstr00010749 |
| | | WBCnstr00014791 |
| | | WBCnstr00016961 |
| | | WBCnstr00017064 |
| | Antibody (12) |
| | Microarray_results (34) |
| | Expression_cluster (208) |
| | Interaction (56) |
| Map_info | Map | V | Position | 0.477486 | Error | 0.002969 |
| | Well_ordered |
| | Positive | Inside_rearr | sDf20 |
| | | Positive_clone | K11C4 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | M04C11 |
| | Negative | Outside_rearr | nDf31 |
| | | Negative_clone | M04C11 |
| | Mapping_data | 2_point | 310 |
| | | | 2841 |
| | | | 3136 |
| | | | 4524 |
| | | Multi_point (17) |
| | | Pos_neg_data (16) |
| | Landmark_gene |
| Reference (150) |
| Remark | results of mutation site, phenotype, rescue appear in J. Mol. Biol. 267, 849-864. 1997 Sakube, Y., Ando, H. & Kagawa H. |
| Method | Gene |
