WormBase Tree Display for Gene: WBGene00000036

WBGene00000036 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 3
    Name: CGC_name: ace-2 Person_evidence: WBPerson1417
            WBPerson36909
            WBPerson7188
      Sequence_name: Y44E3A.2
      Molecular_name: Y44E3A.2
        Y44E3A.2.1
        CE28363
        Y44E3A.2.2
      Other_name: cest-20
        CELE_Y44E3A.2 Accession_evidence: NDB BX284601
      Public_name: ace-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ace
    Reference_allele: WBVar00145393
    Allele (145)
    Legacy_information: g72 : class B acetylcholinesterase reduced 98%; no behavioral phenotype alone (see ace-1). ES1 ME3. NA12 (g73 etc.).
      [C.elegansII] g72 : class B acetylcholinesterase reduced 98%; no behavioral phenotype alone (see ace-1). ES1 ME3. OA11: g73 etc. [Culotti et al. 1981]
    Strain: WBStrain00022541
      WBStrain00024339
      WBStrain00032627
      WBStrain00040622
      WBStrain00007852
      WBStrain00007853
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (57)
    Paralog (41)
    Structured_description: Concise_description: An acetylcholineesterase involved in the termination of cholinergic nerve transmission; it is predominantly expressed in motoneurons. Paper_evidence: WBPaper00004932
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables acetylcholinesterase activity and protein homodimerization activity. Involved in acetylcholine catabolic process; cholinergic synaptic transmission; and regulation of locomotion. Predicted to be located in extracellular space and plasma membrane. Expressed in several structures, including command interneuron; neurons; pm5; somatic nervous system; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Huntington's disease; artery disease (multiple); and diabetes mellitus (multiple). Is an ortholog of human BCHE (butyrylcholinesterase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (15)
  Molecular_info: Corresponding_CDS: Y44E3A.2
    Corresponding_CDS_history: Y44E3A.2a:wp264
      Y44E3A.2b:wp264
    Corresponding_transcript: Y44E3A.2.1
      Y44E3A.2.2
    Other_sequence (77)
    Associated_feature (13)
  Experimental_info: RNAi_result: WBRNAi00027756 Inferred_automatically: RNAi_primary
      WBRNAi00056556 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2633
      Expr12715
      Expr1017666
      Expr1030016
      Expr1160030
      Expr2009143
      Expr2027380
    Drives_construct (19)
    Construct_product: WBCnstr00009876
      WBCnstr00022777
    Regulate_expr_cluster: WBPaper00044452:ace_1_ace-2_downregulated
      WBPaper00044452:ace_1_ace-2_upregulated
    Microarray_results (18)
    Expression_cluster (108)
    Interaction (41)
  Map_info: Map: I Position: -3.85604 Error: 0.023989
    Well_ordered
    Positive: Positive_clone: Y44E3A Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 1019
        3681
      Multi_point (5)
      Pos_neg_data: 8067
        8532
  Reference (85)
  Method: Gene