WormBase Tree Display for Gene: WBGene00000875
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| WBGene00000875 | SMap | S_parent | Sequence | K08E3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cyk-4 | Person_evidence | WBPerson75 | |||||
| Sequence_name | K08E3.6 | ||||||||
| Molecular_name | K08E3.6 | ||||||||
| K08E3.6.1 | |||||||||
| CE18872 | |||||||||
| Other_name | CELE_K08E3.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | cyk-4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyk | ||||||||
| Allele (46) | |||||||||
| Legacy_information | [Schnabel H] maternal effect embryonic lethal with cytokinesis defect | ||||||||
| [Glotzer, M] cytokinesis defective defective in central spindle assembly | |||||||||
| Complementation_data | [Glotzer, M] uncovered by tDf6, tDf10, ctDf2 not uncovered by ctDF3 | ||||||||
| Strain | WBStrain00002137 | ||||||||
| WBStrain00001426 | |||||||||
| WBStrain00036127 | |||||||||
| WBStrain00007362 | |||||||||
| WBStrain00007783 | |||||||||
| WBStrain00007805 | |||||||||
| WBStrain00007352 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00010374 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | cyk-4 encodes a Rho GAP (Rho guanosine triphosphatase (GTPase) activating protein); during development, cyk-4 is required for two different processes: 1) paternally provided CYK-4 regulates anterior-posterior polarity in the one-cell embryo by controlling the actomyosin cytoskeletal network, and 2) together with ZEN-4, CYK-4 is sufficient to promote formation of the large bundles of microtubules that form the central spindle during anaphase and polarize the foregut epithelium; in addition, CYK-4 is required for fertility and coordinated locomotion postembryonically; CYK-4 is enriched in sperm and also localizes to the central spindle during anaphase interdependently with ZEN-4; CYK-4 interacts with ZEN-4 in vitro and in vivo. | Paper_evidence | WBPaper00004196 | |||||
| WBPaper00005208 | |||||||||
| WBPaper00024189 | |||||||||
| WBPaper00028395 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 30 Jun 2008 00:00:00 | ||||||||
| Automated_description | Enables GTPase activator activity. Involved in mitotic cleavage furrow ingression; mitotic spindle midzone assembly; and polar body extrusion after meiotic divisions. Located in mitotic spindle midzone and plasma membrane. Part of centralspindlin complex. Expressed in germ cell; gonad; and tail. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia. Is an ortholog of human RACGAP1 (Rac GTPase activating protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1338 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9804) | ||||
| Molecular_info | Corresponding_CDS | K08E3.6 | |||||||
| Corresponding_transcript | K08E3.6.1 | ||||||||
| Other_sequence (15) | |||||||||
| Associated_feature | WBsf651603 | ||||||||
| WBsf667624 | |||||||||
| WBsf667625 | |||||||||
| WBsf667626 | |||||||||
| WBsf667627 | |||||||||
| WBsf995019 | |||||||||
| WBsf995020 | |||||||||
| WBsf1016456 | |||||||||
| WBsf227797 | |||||||||
| WBsf227798 | |||||||||
| Experimental_info | RNAi_result (27) | ||||||||
| Expr_pattern (16) | |||||||||
| Drives_construct | WBCnstr00002310 | ||||||||
| WBCnstr00004303 | |||||||||
| WBCnstr00013813 | |||||||||
| WBCnstr00014212 | |||||||||
| WBCnstr00018678 | |||||||||
| WBCnstr00018679 | |||||||||
| WBCnstr00020797 | |||||||||
| WBCnstr00020798 | |||||||||
| WBCnstr00020799 | |||||||||
| WBCnstr00037230 | |||||||||
| Construct_product (14) | |||||||||
| Antibody | WBAntibody00000289 | ||||||||
| WBAntibody00000491 | |||||||||
| WBAntibody00000492 | |||||||||
| WBAntibody00001132 | |||||||||
| WBAntibody00002837 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (183) | |||||||||
| Interaction (117) | |||||||||
| Map_info | Map | III | Position | 21.5101 | Error | 0.042376 | |||
| Positive | Inside_rearr | tDf6 | |||||||
| tDf10 | |||||||||
| Positive_clone | K08E3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | Multi_point | 5064 | |||||||
| Pos_neg_data | 10209 | ||||||||
| 10257 | |||||||||
| Reference (74) | |||||||||
| Method | Gene |
